Rabbit TOLLIP Polyclonal Antibody | anti-TOLLIP antibody

TOLLIP Antibody

Cat. Num. AAA301502

• Gene Names: TOLLIP; IL-1RAcPIP
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: TOLLIP, Antibody; TOLLIP Antibody; FLJ33531; IL-1RAcPIP; anti-TOLLIP antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total TOLLIP protein.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 274

• Applicable Applications for anti-TOLLIP antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot)
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human TOLLIP.
• Target Name: TOLLIP
• Preparation and Storage: Store at -20 degree C

IF (Immunofluorescence)

(Immunofluorescence analysis of U2OS cell using TOLLIP antibody. Blue: DAPI for nuclear staining.)

WB (Western Blot)

(Western blot analysis of extracts of PC-3 cell lines, using TOLLIP antibody.)

Related Product Information for anti-TOLLIP antibody

Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses (1-3). TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-kB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the Toll/Interleukin-1 receptor (TIR) domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains, including myeloid differentiation factor 88 (MyD88), MyD88-adaptor-like/TIR-associated protein (MAL/TIRAP), Toll-receptor-associated activator of interferon (TRIF), and Toll-receptor-associated molecule (TRAM). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of IkB, which normally maintains NF-kB in an inactive state by sequestering it in the cytoplasm.

Product Categories/Family for anti-TOLLIP antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 21361619
• NCBI GeneID: 54472
• NCBI Accession #: NP_061882.2
• NCBI GenBank Nucleotide #: NM_019009.3
• UniProt Accession #: Q9H0E2; Q9H9E6; Q9UJ69; B3KXC6
• Molecular Weight: 22,812 Da
• NCBI Official Full Name: toll-interacting protein
• NCBI Official Synonym Full Names: toll interacting protein
• NCBI Official Symbol: TOLLIP
• NCBI Official Synonym Symbols: IL-1RAcPIP
• NCBI Protein Information: toll-interacting protein
• UniProt Protein Name: Toll-interacting protein
• UniProt Gene Name: TOLLIP
• UniProt Entry Name: TOLIP_HUMAN