Standard Curve (Sample)
Human Hif1 Alpha ELISA Kit | Hif1 Alpha elisa kit
Human Hif1 Alpha Pre Coated ELISA Kit
Gene Names
HIF1A; HIF1; MOP1; PASD8; HIF-1A; bHLHe78; HIF-1alpha; HIF1-ALPHA; HIF-1-alpha
Reactivity
Human
Applications
ELISA
Synonyms
Hif1 Alpha; N/A; Human Hif1 Alpha Pre Coated ELISA Kit; Hif1 Alpha elisa kit
Reactivity
Human
Sequence Length
826
Applicable Applications for Hif1 Alpha elisa kit
ELISA
Standard Curve (Sample)
Standard Curve (Sample)
Related Product Information for Hif1 Alpha elisa kit
Background/Introduction: Hypoxia inducible factor-1 (HIF) is a heterodimeric protein including an oxygen-regulated alpha subunit and a constitutive expressed beta subunit. Hypoxia inducible factor-1 alpha (HIF- 1alpha) is a master regulator of cellular adaptation to oxygen deprivation and activates transcription of genes involved in tumor metabolism, angiogenesis, invasion and metastasis, all of which are implicated in cancer progression. Several domains of HIF-1alpha mediate protein-protein interaction, which is essential for the formation of the active heterodimer with HIF-1beta. Targeting specific domains of HIF-1alpha might lead to the identification of more selective inhibitors. Alpha subunits are degraded during normoxia mainly through a proteasomedependent pathway after hydroxylation of two proline residues by prolyl-hydroxilases (PHDs). During hypoxia, PHDs are inhibited and HIF-1alpha subunit accumulates, dimerizes with HIF-1beta and drive expression of HIF target genes which include genes involved in angiogenesis and tissue repair such as vascular endothelial growth factor (VEGF) or erythropoietin (EPO) and prolilhydroxilases (PHDs) genes, among others.
Product Categories/Family for Hif1 Alpha elisa kit
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
95,634 Da
NCBI Official Full Name
Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
NCBI Official Synonym Full Names
hypoxia inducible factor 1 alpha subunit
NCBI Official Symbol
HIF1A
NCBI Official Synonym Symbols
HIF1; MOP1; PASD8; HIF-1A; bHLHe78; HIF-1alpha; HIF1-ALPHA; HIF-1-alpha
NCBI Protein Information
hypoxia-inducible factor 1-alpha
UniProt Protein Name
Hypoxia-inducible factor 1-alpha
UniProt Gene Name
HIF1A
UniProt Synonym Gene Names
bHLHe78
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Product Notes
The Human Hif1 Alpha hif1a (Catalog #AAA78469) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA78469 ELISA Kit recognizes Human Hif1 Alpha. AAA Biotech's Hif1 Alpha can be used in a range of immunoassay formats including, but not limited to, ELISA. Researchers should empirically determine the suitability of the Hif1 Alpha hif1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Hif1 Alpha, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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