IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded Rat Pancreas stained with Insulin Monoclonal Antibody (IRDN/794).)
Mouse Cytokeratin 6 (KRT6) Monoclonal Antibody | anti-KRT6 antibody
Cytokeratin 6 (KRT6) (Hyperproliferation-Related Keratin)
Gene Names
KRT6A; K6A; K6C; K6D; PC3; CK6A; CK6C; CK6D; CK-6C; CK-6E; KRT6C; KRT6D
Reactivity
Human, Mouse. Others not known.
Applications
Immunohistochemistry, Immunofluorescence, Flow Cytometry, Functional Assay
Synonyms
Cytokeratin 6 (KRT6), Antibody; Cytokeratin 6 (KRT6) (Hyperproliferation-Related Keratin); CK6A; CK6B; CK6C; CK6D; CK6E; Keratin Type II Cytoskeletal 6A; Keratin Type II Cytoskeletal 6B; Keratin Type II Cytoskeletal 6C; Keratin Type II Cytoskeletal 6D; Keratin Type II Cytoskeletal 6E; KRT6; KRT6A; KRT6B; KRT6C; KRT6D; KRT6E; anti-KRT6 antibody
Host
Mouse
Reactivity
Human, Mouse. Others not known.
Clonality
Monoclonal
Isotype
IgG2a, kappa
Clone Number
KRT6/1702
Specificity
This MAb recognizes a protein of 56kDa, identified as cytokeratin 6 (CK6). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Sequence Length
564
Applicable Applications for anti-KRT6 antibody
IHC (Immunohistochemistry), IF (Immunofluorescence), FCM/FACS (Flow Cytometry)
Immunogen
Recombinant human full-length keratin 6 protein
Cellular Localization
Cytoplasmic
Hu-chromosome Location
12q13.13; 12q13.13; 12q13.13
Positive Control
Tonsil or basal cell carcinoma
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded Rat Pancreas stained with Insulin Monoclonal Antibody (IRDN/794).)
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded Rat Pancreas stained with Insulin Monoclonal Antibody (IRDN/794).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Bladder Carcinoma stained with Cytokeratin 6 Monoclonal Antibody (KRT6/1702))
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Bladder Carcinoma stained with Cytokeratin 6 Monoclonal Antibody (KRT6/1702))
References
Wetzels RH, et. al. American Journal of Pathology, 1991, 138(3):751-63.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
56kDa
NCBI Official Full Name
keratin, type II cytoskeletal 6C
NCBI Official Synonym Full Names
keratin 6A
NCBI Official Symbol
KRT6A
NCBI Official Synonym Symbols
K6A; K6C; K6D; PC3; CK6A; CK6C; CK6D; CK-6C; CK-6E; KRT6C; KRT6D
NCBI Protein Information
keratin, type II cytoskeletal 6C
UniProt Protein Name
Keratin, type II cytoskeletal 6A
UniProt Gene Name
KRT6A
UniProt Synonym Gene Names
K6A; KRT6D; CK-6A; CK-6D; K6A
Similar Products
Product Notes
The KRT6 krt6a (Catalog #AAA214412) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Cytokeratin 6 (KRT6) (Hyperproliferation-Related Keratin) reacts with Human, Mouse. Others not known. and may cross-react with other species as described in the data sheet. AAA Biotech's Cytokeratin 6 (KRT6) can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), IF (Immunofluorescence), FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the KRT6 krt6a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cytokeratin 6 (KRT6), Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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