IHC (Immunohiostchemistry)
(ERBB2/HER2 Antibody-Human Breast, Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit anti-Human ERBB2/HER2 Polyclonal Antibody | anti-ERBB2 antibody
ERBB2/HER2 Rabbit anti-Human Polyclonal Antibody
Gene Names
ERBB2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu
Reactivity
Human
Applications
Immunohistochemistry
Purity
Immunoaffinity purified
Synonyms
ERBB2/HER2, Antibody; ERBB2/HER2 Rabbit anti-Human Polyclonal Antibody; PathPlus ERBB2/HER2 Antibody; ERBB2; C-erb B2/neu protein; CD340; HER2; Herstatin; MLN 19; HER-2; Neu; NGL; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; CD340 antigen; MLN19; p185erbB2; TKR1; anti-ERBB2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, 0.1% Sodium Azide
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-ERBB2 antibody
IHC (Immunohistochemistry)
Target
Human ERBB2/HER2
Immunogen
LP-12771, synthetic peptide
Conjugation
Unconjugated
Family
Protein Kinase
Subfamily
EGF Receptor
Preparation and Storage
Aliquot and store undiluted at -20 degree C or below for up to 1 year. Can be stored undiluted at 4 degree C for up to 1 month. Avoid freeze-thaw cycles.
IHC (Immunohiostchemistry)
(ERBB2/HER2 Antibody-Human Breast, Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(ERBB2/HER2 Antibody-Human Breast, Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(ERBB2/HER2 Antibody-Human Breast, Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(ERBB2/HER2 Antibody-Human Breast, Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE))
Related Product Information for anti-ERBB2 antibody
HER2 antibody is an unconjugated rabbit polyclonal antibody to HER2 (ERBB2) from human. Validated for IHC.
ERBB2 (HER2) is a tyrosine kinase/epidermal growth factor receptor that is overexpressed and mutated in approximately 10-20% of breast cancers. ERBB2 exhibits positive membranous staining in malignant cells, where it promotes cancer cell growth. It is associated with more aggressive tumors. Immunohistochemistry staining of ERBB2 is used alongside the proteins ER (estrogen receptor), PR (progesterone receptor) and Ki-67 to classify different subtypes of breast cancer, and it is a widely used prognostic marker for breast cancer, as levels of ERBB2 expression predict a patient's response to Herceptin therapy. It is also a relevant marker of poor prognosis for other cancers such as ovarian and gastric cancer, and it is mutated in a small percentage of non-small cell lung cancers. In immunohistochemistry, ERBB2 can show either cytoplasmic or membranous staining, but only membranous staining is relevant for cancer.
ERBB2 (HER2) is a tyrosine kinase/epidermal growth factor receptor that is overexpressed and mutated in approximately 10-20% of breast cancers. ERBB2 exhibits positive membranous staining in malignant cells, where it promotes cancer cell growth. It is associated with more aggressive tumors. Immunohistochemistry staining of ERBB2 is used alongside the proteins ER (estrogen receptor), PR (progesterone receptor) and Ki-67 to classify different subtypes of breast cancer, and it is a widely used prognostic marker for breast cancer, as levels of ERBB2 expression predict a patient's response to Herceptin therapy. It is also a relevant marker of poor prognosis for other cancers such as ovarian and gastric cancer, and it is mutated in a small percentage of non-small cell lung cancers. In immunohistochemistry, ERBB2 can show either cytoplasmic or membranous staining, but only membranous staining is relevant for cancer.
References
World Journal of Clinical Oncology. 2014 Aug; 5.3; 382-392, PMID: 25114853; PLoS One. 2018; 13(1): e0191972, PMID: 29381731; Pathogenesis. 2015. 2 (3): 1-9, DOI: 10.1016/j.pathog.2015.05.002; World J Gastroenterol. 2016 May 21; 22(19): 4619 -4625, PMID: 27217694
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
97,253 Da
NCBI Official Full Name
receptor tyrosine-protein kinase erbB-2 isoform a
NCBI Official Synonym Full Names
erb-b2 receptor tyrosine kinase 2
NCBI Official Symbol
ERBB2
NCBI Official Synonym Symbols
NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu
NCBI Protein Information
receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog;
UniProt Protein Name
Receptor tyrosine-protein kinase erbB-2
UniProt Gene Name
ERBB2
UniProt Synonym Gene Names
HER2; MLN19; NEU; NGL; MLN 19
UniProt Entry Name
ERBB2_HUMAN
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Product Notes
The ERBB2 erbb2 (Catalog #AAA163184) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ERBB2/HER2 Rabbit anti-Human Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ERBB2/HER2 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the ERBB2 erbb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ERBB2/HER2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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