ICC (Immunocytochemistry)
(ICC staining ErbB2 in SKOV-3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.)
Rabbit anti-Human HER2/ErbB2 Polyclonal Antibody | anti-HER2/ErbB2 antibody
HER2/ErbB2 Antibody
Gene Names
ERBB2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu
Reactivity
Human
Applications
Immunohistochemistry, Immunocytochemistry, Western Blot
Purity
Peptide affinity purified
Synonyms
HER2/ErbB2, Antibody; HER2/ErbB2 Antibody; Verb b2 erythroblastic leukemia viral oncogene homolog 2; neuro/glioblastoma derived oncogene homolog antibody; C erb B2/neu protein antibody; CD340 antibody; CD340 antigen antibody; Cerb B2/neu protein antibody; CerbB2 antibody; Erb b2 receptor tyrosine kinase 2 antibody; ERBB2 antibody; ERBB2_HUMAN antibody; HER 2 antibody; HER 2/NEU antibody; HER2 antibody; Herstatin antibody; Human epidermal growth factor receptor 2 antibody; Metastatic lymph node gene 19 protein antibody; MLN 19 antibody; MLN19 antibody; NEU antibody; NEU proto oncogene antibody; Neuro/glioblastoma derived oncogene homolog antibody; Neuroblastoma/glioblastoma derived oncogene homolog antibody; NGL antibody; p185erbB2 antibody; Proto-oncogene c-ErbB-2 antibody; Proto-oncogene Neu antibody; Receptor tyrosine-protein kinase erbB-2 antibody; TKR1 antibody; Tyrosine kinase type cell surface receptor HER2 antibody; Tyrosine kinase-type cell surface receptor HER2 antibody; V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) antibody; V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 antibody; V erb b2 avian erythroblastic leukemia viral oncoprotein 2 antibody; V erb b2 erythroblastic leukemia viral oncogene homolog 2; neuro/glioblastoma derived oncogene homolog (avian) antibody; anti-HER2/ErbB2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Purity/Purification
Peptide affinity purified
Form/Format
1*TBS (pH7.4), 0.5%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Applicable Applications for anti-HER2/ErbB2 antibody
IHC (Immunohistochemistry), ICC (Immunocytochemistry), WB (Western Blot)
Immunogen
Peptide
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C.
ICC (Immunocytochemistry)
(ICC staining ErbB2 in SKOV-3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.)
ICC (Immunocytochemistry)
(ICC staining ErbB2 in SKOV-3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.)
IHC (Immunohiostchemistry)
(Immunohistochemical analysis of paraffin-embedded human stomach carcinoma tissue using anti-Her 2 antibody. Counter stained with hematoxylin.)
IHC (Immunohiostchemistry)
(Immunohistochemical analysis of paraffin-embedded human stomach carcinoma tissue using anti-Her 2 antibody. Counter stained with hematoxylin.)
WB (Western Blot)
(Western blot analysis of ErbB2 on different cell lysates using anti- ErbB2 antibody at 1/500 dilution. Positive control: Lane 1: SKOV-3 Lane2: SKBR-3)
WB (Western Blot)
(Western blot analysis of ErbB2 on different cell lysates using anti- ErbB2 antibody at 1/500 dilution. Positive control: Lane 1: SKOV-3 Lane2: SKBR-3)
Related Product Information for anti-HER2/ErbB2 antibody
HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Amplification or overexpression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approx. 30% of breast cancer patients. Over-expression is also known to occur in ovarian, stomach, and aggressive forms of uterine cancer, such as uterine serous endometrial carcinoma. The expression of HER2 is regulated by signaling through estrogen receptors. Normally, estradiol and tamoxifen acting through the estrogen receptor down-regulate the expression of HER2. However, when the ratio of the coactivator AIB-3 exceeds that of the corepressor PAX2, the expression of HER2 is upregulated in the presence of tamoxifen, leading to tamoxifen-resistant breast cancer.
Product Categories/Family for anti-HER2/ErbB2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
137,910 Da
NCBI Official Full Name
receptor tyrosine-protein kinase erbB-2 isoform b
NCBI Official Synonym Full Names
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
NCBI Official Symbol
ERBB2
NCBI Official Synonym Symbols
NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu
NCBI Protein Information
receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived on
UniProt Protein Name
Receptor tyrosine-protein kinase erbB-2
UniProt Gene Name
ERBB2
UniProt Synonym Gene Names
HER2; MLN19; NEU; NGL; MLN 19
UniProt Entry Name
ERBB2_HUMAN
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Product Notes
The HER2/ErbB2 erbb2 (Catalog #AAA312091) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HER2/ErbB2 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's HER2/ErbB2 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ICC (Immunocytochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the HER2/ErbB2 erbb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HER2/ErbB2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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