IF (Immunofluorescence)
(Immunofluorescence analysis of HeLa cell using TARDBP antibody. Blue: DAPI for nuclear staining.)
Rabbit TARDBP Polyclonal Antibody | anti-TARDBP antibody
TARDBP Antibody
Reactivity
Human, Mouse, Rat
Applications
Immunoprecipitation, Immunofluorescence, Immunohistochemistry, Western Blot
Purity
Antigen affinity purification
Synonyms
TARDBP, Antibody; TARDBP Antibody; TARDBP; ALS10; TDP-43; Tdp43; TDP 43; anti-TARDBP antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen affinity purification
Concentration
1mg/mL (varies by lot)
Sequence Length
414
Applicable Applications for anti-TARDBP antibody
IP (Immunoprecipitation), IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot)
Immunogen
Recombinant protein of human TARDBP
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-102127 / sc-292299
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
IF (Immunofluorescence)
(Immunofluorescence analysis of HeLa cell using TARDBP antibody. Blue: DAPI for nuclear staining.)
IF (Immunofluorescence)
(Immunofluorescence analysis of HeLa cell using TARDBP antibody. Blue: DAPI for nuclear staining.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded rat brain lung using TARDBP antibody at dilution of 1:200 (400x lens).)
IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded rat brain lung using TARDBP antibody at dilution of 1:200 (400x lens).)
WB (Western Blot)
(Western blot analysis of extracts of various cell lines, using TARDBP antibody.)
WB (Western Blot)
(Western blot analysis of extracts of various cell lines, using TARDBP antibody.)
Related Product Information for anti-TARDBP antibody
TDP43 (TAR DNA-binding protein 43) is involved in transcriptional regulation and exon splicing (1, 2). While normal TDP43 is a nuclear protein, pathological TDP43 is a component of insoluble aggregates in patients with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). In these disorders, TDP43 is abnormally ubiquitinated, phosphorylated and cleaved to generate carboxy-terminal fragments that are sequestered as insoluble aggregates in neuronal nuclei, perikarya, and neurites (3, 4). Additionally, TDP43 inhibits the expression of the HIV-1 gene and regulates CFTR gene splicing (1, 5).
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
31,808 Da
NCBI Official Full Name
TARDBP
UniProt Protein Name
TAR DNA-binding protein 43
UniProt Gene Name
TARDBP
UniProt Synonym Gene Names
TDP43; TDP-43
UniProt Entry Name
TADBP_HUMAN
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Product Notes
The TARDBP tardbp (Catalog #AAA169931) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TARDBP Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TARDBP can be used in a range of immunoassay formats including, but not limited to, IP (Immunoprecipitation), IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the TARDBP tardbp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TARDBP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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