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▼Active Proteins
AAA Biotech also known as AAA Bio or AAABio provides a variety of high-quality recombinant and natural/native proteins that are proven to work in a wide range of experiments. Explore our products to find the active protein that best fits your needs or experimental model.
Viewing 1100-1150 of 2875 product results
SDS-PAGE
SurA, Active Protein (Cat# AAA48603)
Full Name
SurA, 21-428aa, E Coli, His tag, E Coli (Bioactivity Validated)
Gene Names
surA; ECK0054; JW0052
Applications
SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
Bioactivity
(Urokinase Plasminogen Activator (uPA), also known as u-plasminogen activator or urokinase, is a highly-specific serine protease from the peptidase S1 family that cleaves plasminogen to form plasmin making it a key player in the plasminogen activator (PA) system. Expression of uPA is minimal in normal cells but is increased several fold in tumor cells by extracellular stimuli elevated in cancer and corresponds to poor outcomes in several types of cancer. Therefore, uPA has been identified as an excellent target for therapeutic development through inhibition of protease activity or though inhibition of uPA-dependent signaling while in complex with uPA receptor (uPAR). The activity assay of uPA was measured by its ability to cleave a peptide substrate, N-carbobenzyloxy-Gly-Gly-Arg-7-amido-4-methylcoumarin (Z-GGR-AMC). The reaction was performed in 50 mM Tris, 0.01% Tween-20, pH 8.5 (Assay Buffer), ainitiated by addition 50 uL of 1.5 ug/ml uPA (diluted by Assay Buffer) to 50 uL of 200 uM Substrate. Read at excitation and emission wavelengths of 380 nm and 460 nm (top read), respectively, in kinetic mode for 5 minutes. The specific activity of recombinant mouse uPA is >700 pmol/min/ug.)
Plasminogen Activator, Urokinase (uPA), Active Protein (Cat# AAA161707)
Full Name
Active Plasminogen Activator, Urokinase (uPA)
Gene Names
Plau; uPA; u-PA
Applications
Activity Assay, Cell Culture
Purity
Greater than 95% by SDS-PAGE
Pricing
Application Data
FGF8, Active Protein (Cat# AAA214272)
Full Name
Recombinant Human FGF8
Gene Names
FGF8; HH6; AIGF; KAL6; FGF-8; HBGF-8
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
(Measured by its binding ability in a functional ELISA. Immobilized mouse EPHB3-His at 10 ug/mL (100 uL/well) can bind mouse EFNB3-Fc, the EC50 of mouse EFNB3-Fc is 1-50 ng/mL.)
Ephrin B3, Active Protein (Cat# AAA258238)
Full Name
Ephrin B3 Protein, Mouse, Recombinant (ECD, hFc Tag)
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
(Loaded Anti-CD97 Antibody on AMC Biosensor, can bind CD97 Protein, Human, Recombinant (His Tag) with an affinity constant of 0.2 nM as determined by Octet RED System.)
CD97, Active Protein (Cat# AAA257974)
Full Name
CD97 Protein, Human, Recombinant (His Tag)
Gene Names
ADGRE5; CD97; TM7LN1
Purity
>85% as determined by SDS-PAGE
Pricing
Application Data
COVID 19 Spike S1 Coronavirus, Active Protein (Cat# AAA268890)
Full Name
SARS-CoV-2 (2019-nCoV) Spike Protein (S1 Subunit, mFc Tag)
Purity
>85 % as determined by SDS-PAGE.
Pricing
Application Data
COVID 19 Spike S1 Coronavirus, Active Protein (Cat# AAA268891)
Full Name
SARS-CoV-2 (2019-nCoV) Spike Protein (S1 Subunit, Fc Tag)
Purity
>85 % as determined by SDS-PAGE.
Pricing
Indian Hedgehog, Active Protein (Cat# AAA39005)
Full Name
Recombinant Human Indian Hedgehog
Gene Names
IHH; BDA1; HHG2
Purity
Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Pricing
Insulin Like Growth Factor-1 Des, Active Protein (Cat# AAA38547)
Full Name
Recombinant Human Insulin Like Growth Factor-1 Des (1-3)
Gene Names
IGF1; IGFI; IGF-I; IGF1A
Purity
Greater than 97.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Pricing
Malate Dehydrogenase 2, Active Protein (Cat# AAA38044)
Full Name
Recombinant Mouse Malate Dehydrogenase 2
Gene Names
Mdh2; MDH; Mor1; Mdh-2; Mor-1
Purity
Greater than 95.0% as determined by SDS-PAGE.
Pricing
tissue plasminogen activator, >85% single chain, Active Protein (Cat# AAA37793)
Full Name
Human tissue plasminogen activator, >85% single chain
Gene Names
PLAT; TPA; T-PA
Purity
>95% by SDS-PAGE analysis
Pricing
Bioactivity
(Figure 2. Inhibition of A549 cells proliferation after stimulated with TNF-beta)
Tumor Necrosis Factor Beta (TNFb), Active Protein (Cat# AAA152996)
Full Name
Active Tumor Necrosis Factor Beta (TNFb)
Gene Names
Lta; Tnfb
Applications
Activity Assay, Cell Culture
Purity
Greater than 90% by SDS-PAGE
Pricing
Application Data
(Immobilized human EPHA3-His at 10 ug/ml (100 ul/well) can bind canine EFNA5-Fc, The EC50 of canine EFNA5-Fc is 11.5-26.7 ng/ml.)
Ephrin A5, Active Protein (Cat# AAA258254)
Full Name
Ephrin A5 Protein, Canine, Recombinant (hFc Tag)
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
(Measured by its ability to bind rat Fc-VEGFC in functional ELISA.)
Neuropilin-2, Active Protein (Cat# AAA258245)
Full Name
Neuropilin-2 Protein, Mouse, Recombinant (His Tag)
Gene Names
Nrp2; Np2; Np-2; Npn2; Npn-2; 1110048P06Rik
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
(Measured in a cell proliferation assay using BALB/c 3T3 mouse fibroblasts. The ED50 for this effect is typically 1-6 ng/mL.)
FGF6, Active Protein (Cat# AAA257976)
Full Name
FGF6 Protein, Human, Recombinant
Gene Names
FGF6; HST2; HBGF-6
Purity
>95% as determined by SDS-PAGE
Pricing
Sequence
Interleukin 12B (IL12B), Active Protein (Cat# AAA150970)
Full Name
Active Interleukin 12B (IL12B)
Gene Names
IL12B; CLMF; NKSF; CLMF2; NKSF2; IL-12B
Applications
Activity Assay, Cell Culture
Purity
Greater than 95% by SDS-PAGE
Pricing
Bioactivity
(Lactotransferrin (LTF), also known as actoferrin (LF) , is a multifunctional protein of the transferrin family. Lactoferrin belongs to the innate immune system. Apart from its main biological function, namely binding and transport of iron ions, lactoferri)
Lactoferrin (LTF), Active Protein (Cat# AAA153058)
Full Name
Active Lactoferrin (LTF)
Gene Names
LTF; PLF
Applications
Activity Assay, Cell Culture
Purity
Greater than 90% by SDS-PAGE
Pricing
gamma-Glutamyl Transferase, Active Protein (Cat# AAA44798)
Full Name
Gamma-glutamyl Transferase (gGT), Porcine Kidney
Gene Names
GGT1; GGT; GTG; CD224; GGT 1; D22S672; D22S732
Purity
Purified
SDS-PAGE
(SDS-PAGE of 73kDa Hsc70 protein)
Hsc70, Active Protein (Cat# AAA103775)
Full Name
Recombinant Human HSC70
Gene Names
HSPA8; LAP1; HSC54; HSC70; HSC71; HSP71; HSP73; LAP-1; NIP71; HEL-33; HSPA10; HEL-S-72p
Applications
Functional Assay, Western Blot
Purity
Affinity Purified
Pricing
soluble CD40 Ligand/TRAP, Active Protein (Cat# AAA38130)
Full Name
Recombinant Human soluble CD40 Ligand/TRAP
Gene Names
CD40LG; IGM; IMD3; TRAP; gp39; CD154; CD40L; HIGM1; T-BAM; TNFSF5; hCD40L
Purity
Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Pricing
Prolyl 4-Hydroxylase Beta, Active Protein (Cat# AAA39146)
Full Name
Recombinant Human Prolyl 4-Hydroxylase Beta, Active
Gene Names
P4HB; DSI; GIT; PDI; PHDB; PDIA1; PO4DB; PO4HB; PROHB; CLCRP1; ERBA2L; P4Hbeta
Purity
Greater than 90.0% as determined by SDS-PAGE.
Pricing
Interleukin-17 A/F, Active Protein (Cat# AAA38661)
Full Name
Recombinant Rat Interleukin-17 A/F Heterodimer
Gene Names
IL17A; IL17; CTLA8; IL-17; IL-17A
Purity
Greater than 98.0% as determined by HPLC and SDS-PAGE.
Pricing
Application Data
(Measured by its binding ability in a functional ELISA. Immobilized Mouse TNFSF13 at 2 ug/mL (100 ul/well) can bind Human BCMA, The EC50 of Human BCMA is 0.6-2.1 ng/mL.)
BCMA, Active Protein (Cat# AAA257903)
Full Name
BCMA Protein, Human, Recombinant (ECD, His Tag)
Gene Names
TNFRSF17; BCM; BCMA; CD269; TNFRSF13A
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
(Measured in a cell proliferation assay using 4MBr-5 rhesus monkey epithelial cells. The ED50 for this effect is 20-120 ng/mL.)
KGF/FGF-7, Active Protein (Cat# AAA257846)
Full Name
KGF/FGF-7 Protein, Human, Recombinant (His Tag)
Gene Names
FGF7; KGF; HBGF-7
Purity
>95% as determined by SDS-PAGE
Pricing
Bioactivity
(HTRF Assay for Recombinant PDGFRB (557-1106 activity. 1 uM TK substrate was incubated with different concentrations of PDGFRB (557-1106) protein in 10 ul reaction system containing 1×Enzymatic Buffer, 5 mM MgCl2, 1 mM MnCl, 1 mM DTT, 5 nM SEB and 100 uM ATP for 1 hour. Then 10 ul detection reagents containing anti-TK antibody (1:2) and SA-XL665 (1:100) diluted with 1× Detection Buffer were added and incubated with the reactions for 30 min. All the operations and reactions were performed at room temperature.)
PDGFRB, Active Protein (Cat# AAA60333)
Full Name
Recombinant PDGFRB (557-1106) protein
Purity
>50%
Pricing
WB (Western Blot)
(Figure 4. Western BlotSample: Recombinant LMTK3, Human;Antibody: Rabbit Anti-Human LMTK3 Ab)
Lemur Tyrosine Kinase 3 (LMTK3), Active Protein (Cat# AAA146624)
Full Name
Active Lemur Tyrosine Kinase 3 (LMTK3)
Gene Names
LMTK3; LMR3; TYKLM3; PPP1R101
Reactivity
Homo sapiens (Human)
Applications
Invitro Assay, Activity Assay, Cell Culture
Purity
>95%
Pricing
WB (Western Blot)
(Western BlotSample: Recombinant MDM2, Human;Antibody: Rabbit Anti-Human MDM2 Ab)
Mdm2 p53 Binding Protein Homolog (MDM2), Active Protein (Cat# AAA148216)
Full Name
Active Mdm2 p53 Binding Protein Homolog (MDM2)
Gene Names
MDM2; HDMX; hdm2; ACTFS
Applications
Activity Assay, Cell Culture
Purity
>95%
Pricing
Interleukin-1 beta, Active Protein (Cat# AAA38108)
Full Name
Recombinant Human Interleukin-1 beta
Gene Names
IL1B; IL-1; IL1F2; IL1-BETA
Purity
Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Pricing
Granulocyte Macrophage-Colony Stimulating Factor, Active Protein (Cat# AAA38116)
Full Name
Recombinant Mouse Granulocyte Macrophage-Colony Stimulating Factor
Gene Names
Csf2; Csfgm; GMCSF; Gm-CSf; MGI-IGM
Purity
Greater than 98.0% as determined by
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Pricing
Application Data
BMP-2, Active Protein (Cat# AAA79170)
Full Name
Human BMP-2
Gene Names
BMP2; BDA2; BMP2A
Reactivity
Human
Purity
> 95% by SDS-PAGE & silver stain
Pricing
Bioactivity
(Tissue inhibitors of metalloproteinase 1 (TIMP1) is a member of the family of proteins that regulate the activation and proteolytic activity of the zinc enzymes known as matrix metalloproteinases (MMPs). TIMP-1 is a glycoprotein with a molecular mass of 28 kDa produced by a wide range of cell types. TIMP-1 inhibits active MMP-mediated proteolysis by forming an N-terminal, non-covalent binary complex with the MMP active site. The activity of recombinant sheep TIMP1 was measured by its ability to inhibit rhMMP2 cleavage of a fluorogenic peptide substrate MCA-Pro-Leu-Gly-Leu-DPA-Ala-Arg-NH2 in the assay buffer 50 mM Tris, 10 mM CaCl2, 150 mM NaCl, 0.05% (w/v) Brij-35, pH 7.5. rhMMP2 was diluted to 100 ug/ml and activated with 1 mM APMA at 37 degree C for 1 hour and roTIMP1 (MW: 23.2 KD) was diluted to different concentrations with the assay buffer. Mix 8 ul of roTIMP1 curve dilutions, 12.8 ul of activated rhMMP-2, and 59.2 ul of assay buffer, including a control containing assay buffer and the diluted rhMMP-2 and incubate the reactions for 2 hours at 37 degree C. Loading 50 ul of the incubated mixtures which were diluted five-fold in assay buffer into empty wells of a plate, and start the reaction by adding 50 ul of 20 uM substrate. Include a substrate blank containing 50 ul of assay buffer and 50 ul of 20 uM substrate. Then read at excitiation and emission wavelengths of 320 nm and 405 nm, respectively, in kinetic mode for 5 minutes. The result was shown in Figure 1 and it was obvious that recombinant sheep TIMP1 significantly decreased rhMMP2 activity. The inhibition IC50 was )
Tissue Inhibitors Of Metalloproteinase 1 (TIMP1), Active Protein (Cat# AAA161744)
Full Name
Active Tissue Inhibitors Of Metalloproteinase 1 (TIMP1)
Gene Names
TIMP1; TIMP-1
Applications
Activity Assay, Cell Culture
Purity
Greater than 90% by SDS-PAGE
Pricing
Application Data
IFNG, Active Protein (Cat# AAA214335)
Full Name
Recombinant Rat IFNG
Gene Names
Ifng; IFNG2
Purity
>95% as determined by SDS-PAGE
Pricing
Purity Info
PDE7B, Active Protein (Cat# AAA73106)
Full Name
PDE7B, Active
Gene Names
PDE7B; bA472E5.1
Purity
>75%
Pricing
STREPTOLYSIN-O, Active Protein (Cat# AAA50417)
Full Name
RECOMBINANT STREPTOLYSIN-O
Applications
ELISA
Pricing
Fibrinogen, Active Protein (Cat# AAA37779)
Full Name
Human Fibrinogen
Gene Names
FGA; Fib2
Purity
>95% by SDS-PAGE analysis
Pricing
Procalcitonin (PCT), Active Protein (Cat# AAA44759)
Full Name
Procalcitonin (PCT) antigen
Applications
Immunoassay, Control
Purity
>90% (SDS-PAGE)
Pricing
SDS-PAGE
IL-1beta, Active Protein (Cat# AAA48475)
Full Name
IL-1beta, 117-269aa, Human, E Coli (Bioactivity Validated)
Gene Names
IL1B; IL-1; IL1F2; IL1-BETA
Applications
SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
Transforming Growth Factor-Beta 1, Active Protein (Cat# AAA38647)
Full Name
Human Transforming Growth Factor-Beta 1
Gene Names
TGFB1; CED; LAP; DPD1; TGFB; TGFbeta
Purity
Greater than 98.0% as determined by SDS-PAGE.
Pricing
Coagulation Factor VIII, Active Protein (Cat# AAA38430)
Full Name
Recombinant Human Coagulation Factor VIII
Gene Names
F8; AHF; F8B; F8C; HEMA; FVIII; DXS1253E
Purity
Greater than 97.0% as determined by SDS-PAGE.
Pricing
Gene Sequence
Interferon Beta (IFNb), Active Protein (Cat# AAA150973)
Full Name
Active Interferon Beta (IFNb)
Gene Names
IFNB1; IFB; IFF; IFNB
Applications
Activity Assay, Cell Culture
Purity
Greater than 97% by SDS-PAGE
Pricing
Application Data
VEGF, Active Protein (Cat# AAA214255)
Full Name
Recombinant Human VEGF (165aa)
Gene Names
VEGFA; VPF; VEGF; MVCD1
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
Interleukin 20 (IL20), Active Protein (Cat# AAA148137)
Full Name
Active Interleukin 20 (IL20)
Gene Names
IL20; IL-20; IL10D; ZCYTO10
Reactivity
Human
Applications
Activity Assay, Cell Culture
Purity
> 90%
Pricing
Application Data
IL-3, Active Protein (Cat# AAA79193)
Full Name
Human IL-3
Gene Names
IL3; IL-3; MCGF; MULTI-CSF
Reactivity
Human
Purity
> 98% by SDS-PAGE & silver stain
Pricing
Interleukin-4, Active Protein (Cat# AAA38110)
Full Name
Recombinant Human Interleukin-4
Gene Names
IL4; BSF1; IL-4; BCGF1; BSF-1; BCGF-1
Purity
Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Pricing
Parathyroid Hormone, Active Protein (Cat# AAA38562)
Full Name
Recombinant Human Parathyroid Hormone (7-34)
Gene Names
PTH1R; PFE; PTHR; PTHR1
Purity
Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Pricing
IFN GAMMA, Active Protein (Cat# AAA50534)
Full Name
RECOMBINANT HUMAN INTERFERON GAMMA
Gene Names
IFNG; IFG; IFI
Applications
Western Blot, Functional Assay
Purity
>98% by SDS PAGE and HPLC
Pricing
Bioactivity
(PRL (prolactin), also known as luteotropin, is a hormone secreted from the pituitary gland and is best known for its role in enabling mammals to produce milk. PRL plays an essential role in metabolism, regulation of the immune system through activating its specific membrane-anchored receptor (PRLR). A functional binding ELISA assay was conducted to detect the interaction of recombinant horse PRL and recombinant human PRLR. Briefly, PRL was diluted serially in PBS with 0.01% BSA (pH 7.4). Duplicate samples of 100 ul were then transferred to PRLR-coated microtiter wells and incubated for 1h at 37 degree C. Wells were washed with PBST and incubated for 1h with anti-PRL pAb, then aspirated and washed 3 times. After incubation with HRP labelled secondary antibody for 1h at 37 degree C, wells were aspirated and washed 5 times. With the addition of substrate solution, wells were incubated 15-25 minutes at 37 degree C. Finally, add 50 uL stop solution to the wells and read at 450/630 nm immediately. The binding activity of recombinant horse PRL and recombinant human PRLR was shown in Figure 1, the EC50 for this effect is 0.11 ug/mL.)
Prolactin (PRL), Active Protein (Cat# AAA161789)
Full Name
Active Prolactin (PRL)
Gene Names
PRL; GHA1
Applications
Activity Assay, Cell Culture
Purity
Greater than 95% by SDS-PAGE
Pricing
Application Data
(Measured by its ability to inhibit mouse CSF induced proliferation of M-NFS-60 mouse myelogenous leukemia lymphoblast cells. The ED50 for this effect is typically 50-250 ng/mL in the presence of 2.5 ng/mL Recombinant Mouse M-CSF.)
CSF1R, Active Protein (Cat# AAA258261)
Full Name
CSF1R Protein, Rat, Recombinant (hFc Tag)
Gene Names
Csf1r; c-fms; mrfms; CSF-1R; CSF-1-R; M-CSF-R
Purity
>95% as determined by SDS-PAGE
Pricing
Soluble Fibrin, Active Protein (Cat# AAA37871)
Full Name
Soluble Mouse Fibrin
Gene Names
Fga; Fib
Purity
>95% by SDS-PAGE analysis
Pricing
Application Data
Calpain 1, Large Subunit (CAPN1), Active Protein (Cat# AAA148200)
Full Name
Active Calpain 1, Large Subunit (CAPN1)
Reactivity
Rat
Applications
Activity Assay, Cell Culture
Purity
> 90%
Pricing
What Are Active Proteins?
Proteins are large molecules made up of long chains of amino acids. They will typically fold into a very particular 3-dimensional shape/conformation, that is sometimes referred to as their “native” form, which allows them to work properly in the body. For the purposes of product categorization, AAA Biotech will typically refer to proteins purified from their original animal host as being “native” proteins (this is to signify their difference compared to their recombinant proteins or “synthetic” protein counterparts).
If a protein successfully folds into the correct shape, it will typically display high fidelity characteristics to its original protein in its original animal host and be classified as an active protein, as it will be able to function “normally” in most enzymatic or binding capacities. If it loses this shape, due to factors such as heat or strong chemicals (such as detergents), it becomes inactive and is no longer able to perform its basic functions.
All of the proteins in this category are made under strict quality control, and they are active, pure, low in contaminants, and stable. Most are stored as freeze-dried powders and come without extra tags, so they’re very close to the actual natural/native form.
Learn more in our guide “How active proteins work”.
Key Applications of Active Proteins
1. Scientific Research
- Aid in the study of how proteins function in the body
- Aid in understanding various disease processes
2. Drug Development
- Powerful tools to investigate how potential drugs interact with specific proteins
- Ideal for identifying drug targets
3. Cell Culture
- Are routinely utilized to support cell growth and function (e.g., using exogenous growth factors)
- Can be used to promote cellular development into specific types (differentiation)
4. Diagnostics
- Regularly utilized in tests to detect diseases or infections (e.g., COVID-19, cancer)
- Note: All products are strictly for research-use only (RUO).
5. Therapeutics
- Some active proteins are used directly as treatments (e.g., insulin, enzymes)
- Note: All products are strictly for research-use only (RUO).
6. Vaccine Development
- Used to create or test vaccines by mimicking parts of viruses or bacteria
7. Biochemical Assays
- They can facilitate the characterization of enzyme activity, binding strength, or protein interactions in lab tests
Why Buy Active Proteins from AAA Biotech?
- High biological activity – Verified to perform as expected or indicated on datasheet
- Strict quality control – We are confident in our active proteins’ reliability and consistency
- High purity & low endotoxin – Ideal for applications involving sensitive or precious samples/components
- Freeze-dried for stability – Long shelf life and straightforward storage
- Mostly tag-free – Closer to natural/native protein form
FAQ
1. What are active proteins used for in research?
Active proteins are used primarily in the study of how proteins function, in characterizing/discovering drug interactions, supporting cell growth, running biochemical assays, and in development of diagnostics or therapeutics.
2. How are AAA Biotech's active proteins validated?
AAA Biotech’s active proteins are validated through strict quality control and functional assays to ensure they are properly folded and active. “Active”, though, can be an ambiguous term, so if a specific “activity” or “binding” capability of a protein is of crucial interest to you, please inquire with us prior to purchase, and we will provide further details on how the “Active” modifier was determined to be applicable.
3. Are these proteins tested for biological activity?
Yes, all active proteins from AAA Biotech are tested to confirm they have the expected biological activity before being offered for use. Though, said “biological activity” can be either “enzymatic”, “binding”, or both.