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AAA Biotech also known as AAA Bio or AAABio provides a variety of high-quality recombinant and natural/native proteins that are proven to work in a wide range of experiments. Explore our products to find the active protein that best fits your needs or experimental model.
Viewing 1200-1250 of 2875 product results
SDS-PAGE
Interleukin 17 Receptor D (IL17RD), Active Protein (Cat# AAA148245)
Full Name
Active Interleukin 17 Receptor D (IL17RD)
Gene Names
IL17RD; SEF; HH18; IL-17RD; IL17RLM
Reactivity
Human
Applications
Activity Assay, Cell Culture
Purity
> 90%
Pricing
Application Data
(Measured by its binding ability in a functional ELISA. Immobilized recombinant human EphB6 at 10 ug/ml (100 ul/well) can bind human EphrinB2 with a linear range of 1.28-32 ng/ml.)
EphB6, Active Protein (Cat# AAA257843)
Full Name
EphB6 Protein, Human, Recombinant (His Tag)
Gene Names
EPHB6; HEP
Purity
>92% as determined by SDS-PAGE
Pricing
Specific Activity
(Sample Activity Plot.)
COVID 19 PLpro Coronavirus, Active Protein (Cat# AAA73170)
Full Name
2019-nCoV PLpro, Active
Pricing
Bioactivity
(Figure. Cell proliferation of MCF-7 cells after stimulated with IGF1.)
Insulin Like Growth Factor 1, Active Protein (Cat# AAA150054)
Full Name
Active Insulin Like Growth Factor 1 (IGF1)
Gene Names
Igf1; Igf-1; Igf-I; C730016P09Rik
Applications
Activity Assay, Cell Culture
Purity
>97%
Pricing
Bioactivity
(Sirtuin 4, also known as SIRT4, is a member of the sirtuin family. SIRT4 is a mitochondrial ADP-ribosyltransferase that inhibits mitochondrial glutamate dehydrogenase 1 activity, thereby downregulating insulin secretion in response to amino acids. It has been shown that SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells. Besides, Heat Shock 60kD Protein 1, Chaperonin (HSPD1) has been identified as an interactor of SIRT4, thus a binding ELISA assay was conducted to detect the interaction of recombinant human SIRT4 and recombinant human HSPD1. Briefly, SIRT4 were diluted serially in PBS, with 0.01% BSA (pH 7.4). Duplicate samples of 100L were then transferred to HSPD1-coated microtiter wells and incubated for 2h at 37. Wells were washed with PBST and incubated for 1h with anti-SIRT4 pAb, then aspirated and washed 3 times. After incubation with HRP labelled secondary antibody, wells were aspirated and washed 3 times. With the addition of substrate solution, wells were incubated 15-25 minutes at 37. Finally, add 50uL stop solution to the wells and read at 450nm immediately. The binding activity of SIRT4 and HSPD1 was shown in Figure 1, and this effect was in a dose dependent manner.Figure. The binding activity of SIRT4 with HSPD1)
Sirtuin 4, Active Protein (Cat# AAA150139)
Full Name
Active Sirtuin 4 (SIRT4)
Gene Names
SIRT4; SIR2L4
Applications
Activity Assay, Cell Culture
Purity
>97%
Pricing
Thrombopoietin, Active Protein (Cat# AAA38170)
Full Name
Recombinant Mouse Thrombopoietin
Gene Names
Thpo; Ml; Tpo; Mgdf; Mpllg
Purity
Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Pricing
Bioactivity
(Elastin (ELN) is an extracellular matrix (ECM) protein responsible for the extensibility and elastic recoil of many vertebrate tissues. ELN is abundant in elastic tissues, and tissues rich in elastin include the aorta and major blood vessels, the lungs, elastic ligaments, tendons and the skin. ELN can bind the elastin receptor complex and other receptors and stimulate migration and proliferation of monocytes and skin fibroblasts. Elastokines can also contribute to cancer progression. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS), autosomal dominant cutis laxa. Decorin (DCN), an extracellular matrix (ECM) protein, is one of targets of ECM. Thus a functional binding ELISA assay was conducted to detect the interaction of recombinant mouse ELN and recombinant human DCN. Briefly, ELN was diluted serially in PBS with 0.01% BSA (pH 7.4). Duplicate samples of 100 ul were then transferred to DCN-coated microtiter wells and incubated for 1h at 37 degree C. Wells were washed with PBST and incubated for 1h with anti-ELN pAb, then aspirated and washed 3 times. After incubation with HRP labelled secondary antibody for 1h at 37 degree C, wells were aspirated and washed 5 times. With the addition of substrate solution, wells were incubated 15-25 minutes at 37 degree C. Finally, add 50 uL stop solution to the wells and read at 450/630 nm immediately. The binding activity of recombinant mouse ELN and recombinant human DCN was shown in Figure 1, the EC50 for this effect is 0.068 ug/mL.)
Elastin (ELN), Active Protein (Cat# AAA161843)
Full Name
Active Elastin (ELN)
Gene Names
Eln; AI385707; AI480567; E030024M20Rik
Applications
Activity Assay, Cell Culture
Purity
Greater than 95% by SDS-PAGE
Pricing
Application Data
(Measured by its ability to inhibit recombinant human BMP4 induced activity in MC3T3-E1 Mouse osteoblastic cells. The ED50 for this effect is typically 0.5-2 ug/ml in the presence of 50 ng/ml of recombinant human BMP4.)
BMPR1A/ALK-3, Active Protein (Cat# AAA258127)
Full Name
BMPR1A/ALK-3 Protein, Mouse, Recombinant (His Tag)
Gene Names
Bmpr1a; ALK3; Bmpr; BMPR-IA; AU045487; 1110037I22Rik
Purity
>97% as determined by SDS-PAGE
Pricing
Application Data
(Measured by its binding ability in a functional ELISA. Immobilized Human ACE2 (mFc tag) at 2 ug/mL (100 uL/well) can bind SARS-CoV-2 (2019-nCoV) Spike RBD (K417T, E484K, N501Y) Protein (His Tag), the EC50 of SARS-CoV-2 (2019-nCoV) Spike RBD (K417T, E484K, N501Y) Protein (His Tag) is 3.0-15.0 ng/mL.)
COVID 19 Spike RBD (K417T, E484K, N501Y) Protein (His Tag) Coronavirus, Active Protein (Cat# AAA258107)
Full Name
SARS-CoV-2 (2019-nCoV) Spike RBD (K417T, E484K, N501Y) Protein (His Tag)
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
(Measured by its binding ability in a functional ELISA. Immobilized human 2B4-His, at 10 ug/mL (100 uL/well) can bind human CD48-Fc. The EC50 of human CD48-Fc is 0.03-0.06 ug/mL.)
CD48, Active Protein (Cat# AAA257928)
Full Name
CD48 Protein, Human, Recombinant (hFc Tag)
Gene Names
CD48; BCM1; BLAST; hCD48; mCD48; BLAST1; SLAMF2; MEM-102
Purity
>90% as determined by SDS-PAGE
Pricing
Acid Phosphatase-1, Active Protein (Cat# AAA38771)
Full Name
Recombinant Human Acid Phosphatase-1
Gene Names
ACP1; HAAP
Purity
Greater than 95.0% as determined by SDS-PAGE.
Pricing
Application Data
IL36G, Active Protein (Cat# AAA214293)
Full Name
Recombinant Human IL36G
Gene Names
IL36G; IL1E; IL1F9; IL1H1; IL-1F9; IL-1H1; IL1RP2; IL-1RP2
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
PlGF, Active Protein (Cat# AAA214308)
Full Name
Recombinant Human PlGF
Gene Names
PGF; PGFL; PIGF; PLGF; PlGF-2; D12S1900; SHGC-10760
Purity
>95% as determined by SDS-PAGE
Pricing
Bioactivity
(HTRF for MRCKa/CDC42BPA (1-473) activity 1 uM STK S3 substrate was incubated with different concentrations of MRCKa/CDC42BPA (1-473) protein in 10 ul reaction system containing 1×Enzymatic Buffer, 5 mM MgCl2, 1 mM DTT and 100 uM ATP for 1 hour. Then 10 ul detection reagents containing anti-STK antibody (1:2) and SA-XL665 (1:100) diluted with 1× Detection Buffer were added and incubated with the reactions for 30 min. All the operations and reactions were performed at room temperature. HTRF assay was used for detection.)
MRCKa/CDC42BPA, Active Protein (Cat# AAA60314)
Full Name
Recombinant MRCKa/CDC42BPA (1-473) protein
Purity
>=95%
Pricing
Application Data
(Measured by its binding ability in a functional ELISA. Immobilized PVRL1/NECTIN1 Protein, Human, Recombinant (His Tag) at 2 ug/ml (100 ul/well) can bind Nectin 3 Protein, Human, Recombinant (ECD, hFc Tag), the EC50 of Nectin 3 Protein, Human, Recombinant (ECD, hFc Tag)is 30-140 ng/mL.)
Nectin 3, Active Protein (Cat# AAA257936)
Full Name
Nectin 3 Protein, Human, Recombinant (ECD, hFc Tag)
Gene Names
PVRL3; PPR3; PRR3; CD113; PVRR3; CDW113; NECTIN-3
Purity
>95% as determined by SDS-PAGE
Pricing
Guanine Deaminase, Active Protein (Cat# AAA39144)
Full Name
Recombinant Human Guanine Deaminase, Active
Gene Names
GDA; CYPIN; GUANASE; NEDASIN
Purity
Greater than 90.0% as determined by SDS-PAGE.
Pricing
Creatine Kinase MB Isoenzyme Type-1, Active Protein (Cat# AAA38099)
Full Name
Recombinant Human Creatine Kinase MB Isoenzyme Type-1
Purity
Greater than 95.0% as determined by SDS-PAGE.
Pricing
Peroxisome Proliferator Activated Receptor Gamma, Active Protein (Cat# AAA38395)
Full Name
Recombinant Human Peroxisome Proliferator Activated Receptor Gamma
Gene Names
PPARG; GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma
Purity
Greater than 90.0% as determined by SDS-PAGE.
Pricing
Thrombin, Active Protein (Cat# AAA44822)
Full Name
Thrombin, Human Plasma
Purity
>= 95% (SDS-PAGE)
Pricing
LDLR / LDL Receptor, Active Protein (Cat# AAA173570)
Full Name
Recombinant Human LDLR Protein (His Tag)(Active)
Gene Names
LDLR; FH; FHC; LDLCQ2
Purity
> 85 % as determined by reducing SDS-PAGE.
Pricing
HLA Class II Histocompatibility Antigen gamma Chain, Active Protein (Cat# AAA174708)
Full Name
Recombinant Mouse HLA Class II Histocompatibility Antigen gamma Chain Protein
Gene Names
CD74; II; p33; DHLAG; HLADG; Ia-GAMMA
Purity
>95% as determined by reducing SDS-PAGE.
Pricing
Sequence
Sex Hormone Binding Globulin (SHBG), Active Protein (Cat# AAA150974)
Full Name
Active Sex Hormone Binding Globulin (SHBG)
Gene Names
SHBG; ABP; SBP; TEBG
Applications
Activity Assay, Cell Culture
Purity
Greater than 97% by SDS-PAGE
Pricing
SDS_PAGE
Perforin 1 (PRF1), Active Protein (Cat# AAA152021)
Full Name
Active Perforin 1 (PRF1)
Gene Names
PRF1; P1; PFP; FLH2; PFN1; HPLH2
Reactivity
Homo sapiens (Human)
Applications
Activity Assay, Cell Culture
Purity
>80%
Pricing
Application Data
(Measured by its ability to inhibit VEGF-dependent proliferation of human umbilical vein endothelial cells (HUVEC). The ED50 for this effect is typically 20-100 ng/mL in the presence of 10 ng/mL rhVEGF165.)
FLT1, Active Protein (Cat# AAA257830)
Full Name
FLT1 Protein, Human, Recombinant (hFc Tag)
Gene Names
FLT1; FLT; FLT-1; VEGFR1; VEGFR-1
Purity
>95% as determined by SDS-PAGE
Pricing
Bioactivity
COVID 19 Spike RBD Coronavirus, Active Protein (Cat# AAA73162)
Full Name
2019-nCoV Spike Protein RBD
Pricing
ACE2, Active Protein (Cat# AAA176999)
Full Name
Recombinant Human ACE2 Protein (Fc Tag)
Gene Names
ACE2; ACEH
Purity
>95% as determined by reducing SDS-PAGE.
Pricing
SARS Associated Coronavirus Spike, Active Protein (Cat# AAA38073)
Full Name
Recombinant SARS Associated Coronavirus Spike (14-1195 a.a.)
Gene Names
S; E2
Purity
Greater than 85.0% as determined by SDS-PAGE.
Pricing
Bioactivity
(Basic fibroblast growth factor (FGF2), also known as bFGF, FGF-beta is a member of a large family of structurally related heparin-binding proteins (the FGFs) involved in the regulation of cell proliferation, growth and differentiation. It involved in many)
Fibroblast Growth Factor 2, Basic (FGF2), Active Protein (Cat# AAA153039)
Full Name
Active Fibroblast Growth Factor 2, Basic (FGF2)
Applications
Activity Assay, Cell Culture
Purity
Greater than 97% by SDS-PAGE
Pricing
Application Data
Interleukin 6 (IL6), Active Protein (Cat# AAA146609)
Full Name
Active Interleukin 6 (IL6)
Gene Names
IL6; IL-6; CHIL-6; interleukin-6
Applications
Activity Assay, Cell Culture
Purity
> 97%
Pricing
Activity
(Creatine Kinase, Brain (CKB) consists of a homodimer of two identical brain-type CK-B subunits. CKB is a cytoplasmic enzyme involved in cellular energy homeostasis, with certain fractions of the enzyme being bound to cell membranes, ATPases, and a variety of ATP-requiring enzymes in the cell. The protein reversibly catalyzes the transfer of "energy-rich" phosphate between ATP and creatine or between phospho-creatine (PCr) and ADP. Besides, Fusion (FUS) has been identified as an interactor of CKB, thus a binding ELISA assay was conducted to detect the interaction of recombinant human CKB and recombinant human FUS. Briefly, CKB were diluted serially in PBS, with 0.01% BSA (pH 7.4). Duplicate samples of 100uL were then transferred to FUS-coated microtiter wells and incubated for 2h at 37°C. Wells were washed with PBST and incubated for 1h with anti-CKB pAb, then aspirated and washed 3 times. After incubation with HRP labelled secondary antibody, wells were aspirated and washed 3 times.With the addition of substrate solution, wells were incubated 15-25 minutes at 37°C. Finally, add 50uL stop solution to the wells and read at 450nm immediately. The binding activity of CKB and FUS was shown in Figure 1, and this effect was in a dose dependent manner.)
Creatine Kinase, Brain (CKB), Active Protein (Cat# AAA149256)
Full Name
Active Creatine Kinase, Brain (CKB)
Gene Names
CKB; BCK; B-CK; CKBB; CPK-B; HEL-211; HEL-S-29
Reactivity
Homo sapiens (Human)
Applications
Activity Assay, Cell Culture
Purity
>95%
Pricing
BETA GALACTOSIDASE, Active Protein (Cat# AAA50519)
Full Name
NATIVE ESCHERICHIA COLI BETA GALACTOSIDASE
Gene Names
lacZ; ECK0341; JW0335
Applications
Functional Assay
Pricing
Oxytocin, Active Protein (Cat# AAA38351)
Full Name
Human Oxytocin
Gene Names
OXT; OT; OT-NPI; OXT-NPI
Purity
Greater than 99.0% as determined by RP-HPLC.
Pricing
SDS-PAGE
NME2, Active Protein (Cat# AAA48916)
Full Name
NME2, 1-152aa, Human, E Coli (Bioactivity Validated)
Gene Names
NME2; PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2
Applications
Enzyme Activity, SDS-PAGE
Purity
> 90% by SDS-PAGE
Pricing
Application Data
FGF-4, Active Protein (Cat# AAA79291)
Full Name
Human FGF-4
Gene Names
FGF4; HST; KFGF; HST-1; HSTF1; K-FGF; HBGF-4
Reactivity
Human
Purity
> 95% by SDS-PAGE & silver stain
Pricing
Bioactivity
(The cytochrome P450 enzyme CYP2E1 catalyzes the oxidative metabolism of many solvents and other small organic molecules. CYP2E1 is expressed in adult and fetal human liver in addition to extrahepatic tissues such as lung and placenta. Treatment of primary cultures of human hepatocytes with ethanol induces CYP2E1 protein, and this is consistent with the finding that hepatic CYP2E1 protein and mRNA levels are increased in individuals with alcoholism. Although only a few drugs (e.g., acetaminophen have been identified as substrates for CYP2E1, many low molecular weight procarcinogens are activated by this cytochrome P450 (P450). Chlorzoxazone 6-hydroxylation, N-nitrosodimethylamine N-demethylation and p-nitrophenol hydroxylation can be used to measure the catalytic activity of CYP2E1. Thus, the recombinant human CYP2E1 activity was measured by its ability to hydroxylate p-nitrophenol to p-nitrocatechol. The reaction was performed in 50 mM potassium phosphate, pH 7.4 (Assay Buffer), initiated by addition 20 uL of 500 ug/ml CYP2E1 to 10 uL of 5 mM substrate p-nitrophenol and 30 ul of 26 mM NADPH in a total volume of 500 ul. Incubated at 37 degree C for 30min, then read at a wavelength of 535 nm after acidification of the reaction mixture with trichloroacetic acid followed by neutralization using 2 M NaOH.)
Cytochrome P450 2E1 (CYP2E1), Active Protein (Cat# AAA161816)
Full Name
Active Cytochrome P450 2E1 (CYP2E1)
Gene Names
CYP2E1; CPE1; CYP2E; P450-J; P450C2E
Applications
Activity Assay, Cell Culture
Purity
Greater than 90% by SDS-PAGE
Pricing
Application Data
(Measured by its binding ability in a functional ELISA. Immobilized Mouse ACVR2B at 2ug/mL (100 ul/well) can bind biotinylated mouse INHBA-His, The EC50 of biotinylated mouse INHBA-His is 40-95 ng/mL.)
ACVR2B, Active Protein (Cat# AAA258137)
Full Name
ACVR2B Protein, Mouse, Recombinant (His Tag)
Gene Names
Acvr2b; ActRIIB
Purity
>94% as determined by SDS-PAGE
Pricing
Application Data
(Immobilized Nectin 3 Protein, Human, Recombinant (ECD, hFc Tag) at 2 ug/ml (100 ul/well) can bind PVRL1/NECTIN1 Protein, Human, Recombinant (His Tag), the EC50 of PVRL1/NECTIN1 Protein, Human, Recombinant (His Tag)is 150-700 ng/mL.)
PVRL1/NECTIN1, Active Protein (Cat# AAA257983)
Full Name
PVRL1/NECTIN1 Protein, Human, Recombinant (His Tag)
Gene Names
PVRL1; ED4; PRR; HIgR; HVEC; OFC7; PRR1; PVRR; CD111; PVRR1; SK-12; CLPED1; nectin-1
Purity
>98% as determined by SDS-PAGE
Pricing
Application Data
(Measured by its binding ability in a functional ELISA. Immobilized mouse EphA6 at 1 ug/ml (100 ul/well) can bind human EphrinA3 / Fc Chimera. The EC50 of human EphrinA3 is 299.2 ng/mL.)
Ephrin A3, Active Protein (Cat# AAA257840)
Full Name
Ephrin A3 Protein, Human, Recombinant (hFc Tag)
Gene Names
EFNA3; EFL2; EPLG3; LERK3; Ehk1-L
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
(Immobilized Cynomolgus mFc-TNFSF12 at 10 ug/ml (100 ul/well) can bind human Fc-TNFRSF12A, The ED50 of human Fc-TNFRSF12A is 0.07-0.15 ug/ml.)
TWEAKR, Active Protein (Cat# AAA257882)
Full Name
TWEAKR Protein, Human, Recombinant (hFc Tag)
Gene Names
TNFRSF12A; FN14; CD266; TWEAKR
Purity
>95% as determined by SDS-PAGE
Pricing
Bioactivity
Tumor Necrosis Factor Receptor Superfamily Member 17 (TNFRSF17), Active Protein (Cat# AAA243734)
Full Name
Recombinant Human Tumor Necrosis Factor Receptor Superfamily Member 17 (TNFRSF17), Partial (Active)
Gene Names
TNFRSF17; BCM; BCMA; CD269; TNFRSF13A
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Pricing
Application Data
VEGF164, Active Protein (Cat# AAA79252)
Full Name
Rat VEGF164
Gene Names
Vegfa; VPF; Vegf; VEGF-A; VEGF164
Reactivity
Rat
Purity
>95%, by SDS-PAGE and silver stain
Pricing
Adiponectin (ACRP30), Active Protein (Cat# AAA79125)
Full Name
Human Adiponectin (ACRP30)
Gene Names
ADIPOQ; ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1
Reactivity
Human
Purity
> 98% by SDS-PAGE analyses
Pricing
Lactate Dehydrogenase 5, Active Protein (Cat# AAA44813)
Full Name
Lactate Dehydrogenase 5 (LDH-5), Human Liver
Pricing
Bioactivity
(Fibroblast Growth Factor 11 (FGF11) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development,)
Fibroblast Growth Factor 11 (FGF11), Active Protein (Cat# AAA153121)
Full Name
Active Fibroblast Growth Factor 11 (FGF11)
Gene Names
FGF11; FHF3; FHF-3; FGF-11
Applications
Activity Assay, Cell Culture
Purity
Greater than 90% by SDS-PAGE
Pricing
Bioactivity
(Figure 2. The hemagglutination assay of GAL12 in V- bottom shaped 96-well microtiter plate.)
Galectin 12 (GAL12), Active Protein (Cat# AAA153028)
Full Name
Active Galectin 12 (GAL12)
Gene Names
Lgals12; Grip1; AW987437
Applications
Activity Assay, Cell Culture
Purity
Greater than 90% by SDS-PAGE
Pricing
Application Data
Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7), Active Protein (Cat# AAA148126)
Full Name
Active Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7)
Gene Names
CD27; T14; S152; Tp55; TNFRSF7; S152. LPFS2
Reactivity
Human
Applications
Activity Assay, Cell Culture
Purity
> 95%
Pricing
Application Data
Colony Stimulating Factor 1, Macrophage (MCSF), Active Protein (Cat# AAA148162)
Full Name
Active Colony Stimulating Factor 1, Macrophage (MCSF)
Gene Names
Csf1; op; Csfm; MCSF; C87615
Reactivity
Mouse
Applications
Activity Assay, Cell Culture
Purity
> 95%
Pricing
Bioactivity
(Fibroblast growth factor 17 (FGF17) is a member of the fibroblast growth factorfamily. FGF family members possess broad mitogenicand cell survival activities and are involved in a varietyof biological processes, including embryonicdevelopment cell growth, morphogenesis, tissue repair, tumor growth, andinvasion. Fibroblast Growth Factor Receptor 1 (FGFR1) is high affinity receptor for FGF17, thus a functional binding ELISA assay was conducted to detect the interaction of recombinant human FGF17 and recombinant human FGFR1. Briefly, biotin-linked FGF17 were diluted serially in PBS, with 0.01% BSA (pH 7.4). Duplicate samples of 100 ul were then transferred to FGFR1-coated microtiter wells and incubated for 1h at 37 degree C. Wells were washed with PBST 3 times and incubation with Streptavidin-HRP for 30min, then wells were aspirated and washed 5 times. With the addition of substrate solution, wells were incubated 15-25 minutes at 37 degree C. Finally, add 50 ul stop solution to the wells and read at 450 nm immediately. The binding activity of recombinant human FGF17 and human FGFR1 was shown in Figure 1, the EC50 for this effect is 0.52 ug/mL.)
Fibroblast Growth Factor 17 (FGF17), Active Protein (Cat# AAA161896)
Full Name
Active Fibroblast Growth Factor 17 (FGF17)
Gene Names
FGF17; HH20; FGF-13; FGF-17
Applications
Activity Assay, Cell Culture
Purity
Greater than 95% by SDS-PAGE
Pricing
Bioactivity
(Collagen Type IV Alpha 1 (COL4a1), a secreted glycoprotein,is a member of the type IV collagen family. COL4a1 is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. It can inhibit angiogenesis and tumor formation, and specifically inhibit endothelial cell proliferation, migration and tubule formation. COL4A1 mutations can remain asymptomatic or cause devastating disease. Neonates and children may present with porencephaly, intracerebral hemorrhage, or hemiparesis, whereas adults tend to develop intracranial aneurysms or retinal arteriolar tortuosities. Glycoprotein VI (GP6) has been identified as an interactor of COL4a1, thus a functional binding ELISA assay was conducted to detect the interaction of recombinant human COL4a1 and recombinant human GP6. Briefly, COL4a1 was diluted serially in PBS with 0.01% BSA (pH 7.4). Duplicate samples of 100 ul were then transferred to GP6-coated microtiter wells and incubated for 1h at 37 degree C. Wells were washed with PBST and incubated for 1h with anti-COL4a1 pAb, then aspirated and washed 3 times. After incubation with HRP labelled secondary antibody for 1h at 37 degree C, wells were aspirated and washed 5 times. With the addition of substrate solution, wells were incubated 15-25 minutes at 37 degree C. Finally, add 50 uL stop solution to the wells and read at 450/630 nm immediately. The binding activity of recombinant human COL4a1 and recombinant human GP6 was shown in Figure 1, the EC50 for this effect is 0.05 ug/mL.)
Collagen Type IV Alpha 1 (COL4a1), Active Protein (Cat# AAA161709)
Full Name
Active Collagen Type IV Alpha 1 (COL4a1)
Gene Names
COL4A1; ICH; HANAC; POREN1; arresten
Applications
Activity Assay, Cell Culture
Purity
Greater than 80% by SDS-PAGE
Pricing
Application Data
(Measured by its binding ability in a functional ELISA. Immobilized MICAh at 10 ug/mL (100 uL/well) can bind S4-Fc3L3-NKG2D, the EC50 of S4-Fc3L3-NKG2D is 200-450 ng/mL.)
MICA, Active Protein (Cat# AAA258009)
Full Name
MICA Protein, Human, Recombinant (His Tag)
Gene Names
MICA; MIC-A; PERB11.1
Purity
>95% as determined by SDS-PAGE
Pricing
What Are Active Proteins?
Proteins are large molecules made up of long chains of amino acids. They will typically fold into a very particular 3-dimensional shape/conformation, that is sometimes referred to as their “native” form, which allows them to work properly in the body. For the purposes of product categorization, AAA Biotech will typically refer to proteins purified from their original animal host as being “native” proteins (this is to signify their difference compared to their recombinant proteins or “synthetic” protein counterparts).
If a protein successfully folds into the correct shape, it will typically display high fidelity characteristics to its original protein in its original animal host and be classified as an active protein, as it will be able to function “normally” in most enzymatic or binding capacities. If it loses this shape, due to factors such as heat or strong chemicals (such as detergents), it becomes inactive and is no longer able to perform its basic functions.
All of the proteins in this category are made under strict quality control, and they are active, pure, low in contaminants, and stable. Most are stored as freeze-dried powders and come without extra tags, so they’re very close to the actual natural/native form.
Learn more in our guide “How active proteins work”.
Key Applications of Active Proteins
1. Scientific Research
- Aid in the study of how proteins function in the body
- Aid in understanding various disease processes
2. Drug Development
- Powerful tools to investigate how potential drugs interact with specific proteins
- Ideal for identifying drug targets
3. Cell Culture
- Are routinely utilized to support cell growth and function (e.g., using exogenous growth factors)
- Can be used to promote cellular development into specific types (differentiation)
4. Diagnostics
- Regularly utilized in tests to detect diseases or infections (e.g., COVID-19, cancer)
- Note: All products are strictly for research-use only (RUO).
5. Therapeutics
- Some active proteins are used directly as treatments (e.g., insulin, enzymes)
- Note: All products are strictly for research-use only (RUO).
6. Vaccine Development
- Used to create or test vaccines by mimicking parts of viruses or bacteria
7. Biochemical Assays
- They can facilitate the characterization of enzyme activity, binding strength, or protein interactions in lab tests
Why Buy Active Proteins from AAA Biotech?
- High biological activity – Verified to perform as expected or indicated on datasheet
- Strict quality control – We are confident in our active proteins’ reliability and consistency
- High purity & low endotoxin – Ideal for applications involving sensitive or precious samples/components
- Freeze-dried for stability – Long shelf life and straightforward storage
- Mostly tag-free – Closer to natural/native protein form
FAQ
1. What are active proteins used for in research?
Active proteins are used primarily in the study of how proteins function, in characterizing/discovering drug interactions, supporting cell growth, running biochemical assays, and in development of diagnostics or therapeutics.
2. How are AAA Biotech's active proteins validated?
AAA Biotech’s active proteins are validated through strict quality control and functional assays to ensure they are properly folded and active. “Active”, though, can be an ambiguous term, so if a specific “activity” or “binding” capability of a protein is of crucial interest to you, please inquire with us prior to purchase, and we will provide further details on how the “Active” modifier was determined to be applicable.
3. Are these proteins tested for biological activity?
Yes, all active proteins from AAA Biotech are tested to confirm they have the expected biological activity before being offered for use. Though, said “biological activity” can be either “enzymatic”, “binding”, or both.