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▼Active Proteins
AAA Biotech also known as AAA Bio or AAABio provides a variety of high-quality recombinant and natural/native proteins that are proven to work in a wide range of experiments. Explore our products to find the active protein that best fits your needs or experimental model.
Viewing 700-750 of 2583 product results
SDS-PAGE
Glutathione S-Transferase (GST), Active Protein (Cat# AAA48483)
Full Name
Glutathione S-Transferase (GST), 1-218 aa, Schistosoma japonicum E Coli (Bioactivity Validated)
Applications
SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
SDS-PAGE
FKBP1a /FKBP12, Active Protein (Cat# AAA48496)
Full Name
FKBP1a /FKBP12, 1-108aa, Human, His tag, E Coli (Bioactivity Validated)
Gene Names
FKBP1A; FKBP1; PKC12; PKCI2; FKBP12; PPIASE; FKBP-12; FKBP-1A
Applications
SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
SDS-PAGE
Fumarase, Active Protein (Cat# AAA48502)
Full Name
Fumarase, 44-510aa, Human, E Coli (Bioactivity Validated)
Gene Names
FH; MCL; FMRD; LRCC; HLRCC; MCUL1
Applications
SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
SDS-PAGE
(3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.)
Peroxiredoxin 2, Active Protein (Cat# AAA48528)
Full Name
Peroxiredoxin 2, 1-198aa, Human, E Coli (Bioactivity Validated)
Gene Names
PRDX2; PRP; TSA; PRX2; PTX1; TPX1; NKEFB; PRXII; TDPX1; NKEF-B; HEL-S-2a
Applications
Enzyme Activity, SDS-PAGE
Purity
> 90% by SDS-PAGE
Pricing
SDS-PAGE
PRDX4, Active Protein (Cat# AAA48624)
Full Name
PRDX4, 38-271aa, Human, His tag, E Coli (Bioactivity Validated)
Gene Names
PRDX4; PRX-4; AOE372; AOE37-2; HEL-S-97n
Applications
SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
SDS-PAGE
CDA, Active Protein (Cat# AAA48626)
Full Name
CDA, 1-146aa, Human, His tag, E Coli (Bioactivity Validated)
Gene Names
CDA; CDD
Applications
SDS-PAGE
Purity
> 90% by SDS-PAGE
Pricing
Application Data
VEGF120, Active Protein (Cat# AAA79154)
Full Name
Rat VEGF120
Gene Names
Vegfa; VPF; Vegf; VEGF-A; VEGF164
Reactivity
Rat
Purity
>95%, by SDS-PAGE and silver stain
Pricing
FGFR-2/Fc Chimera, soluble, Active Protein (Cat# AAA79161)
Full Name
Human FGFR-2/Fc Chimera, soluble
Gene Names
FGFR2; BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM
Reactivity
Human
Purity
> 90% by SDS-PAGE & silver stain
Pricing
Application Data
(Functional ELISA to test the binding of sTIE-2 to its ligand Ang-2. Ang-2 was coated on the plate and increasing amounts of recombinant human soluble sTIE-2 was added.)
TIE-2, soluble, Active Protein (Cat# AAA79167)
Full Name
Human TIE-2, soluble
Gene Names
TEK; TIE2; VMCM; TIE-2; VMCM1; CD202B
Reactivity
Human
Purity
> 95% by SDS-PAGE & silver stain
Pricing
Application Data
VEGFR-1/Flt-1 (D5), soluble, Active Protein (Cat# AAA79171)
Full Name
Human VEGFR-1/Flt-1 (D5), soluble
Gene Names
FLT1; FLT; FLT-1; VEGFR1; VEGFR-1
Reactivity
Human
Purity
> 90% by SDS-PAGE & silver stain
Pricing
Application Data
(Galectin 3 (GAL3) is a member of the lectin family, of which 14 mammalian galectins have been identified. It is also a member of the beta-galactoside-binding protein family that plays an important role in cell-cell adhesion, cell-matrix interactions, macrophage activation, angiogenesis, metastasis, apoptosis. The protein also has been demonstrated to be involved in cancer, inflammation and fibrosis, heart disease, and stroke. GAL3 is expressed in the nucleus, cytoplasm, mitochondrion, cell surface, and extracellular space. It also can agglutinate red blood. In this case, we choose rabbit erythrocyte (RaE) to assay its ability of agglutination. A general procedure for hemagglutination assay (HA) is as follows, two-fold dilute the recombinant rat GAL3 with 0.01M PBS (pH7.4), add 50L a serial dilution of GAL3 to each well of a U or V-bottom shaped 96-well microtiter plate. The final well serves as a negative control with no GAL3, replace with 50L 0.01M PBS. Then add 50L 1% RaE to each well and mixed gently. The plate is incubated for 1-2 hours at room temperature. The results are shown in Figure 1. The minimal effective concentration of GAL3 is 2.5g/mL. (A) 1% RaE treated with 2.5g/mL GAL3 for 2h; (B) Negative control without GAL3.Figure. The hemagglutination activity of recombinant rat GAL3.)
Galectin 3, Active Protein (Cat# AAA150087)
Full Name
Active Galectin 3 (GAL3)
Gene Names
Lgals3; L-34; CBP30; gal-3; AGE-R3
Applications
Activity Assay, Cell Culture
Purity
>90%
Pricing
Bioactivity
(Tumor protein p53 (TP53), also known as p53, cellular tumor antigen p53 has many mechanisms of anticancer function and plays a role in apoptosis, genomic stability, and inhibition of angiogenesis. TP53 act as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. It also Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. Besides, CREB Binding Protein (CREBBP) has been identified as an interactor of TP53, thus a binding ELISA assay was conducted to detect the interaction of recombinant rat TP53 and recombinant rat CREBBP. Briefly, TP53 were diluted serially in PBS, with 0.01% BSA (pH 7.4). Duplicate samples of 100L were then transferred to CREBBP-coated microtiter wells and incubated for 2h at 37. Wells were washed with PBST and incubated for 1h with anti-TP53 pAb, then aspirated and washed 3 times. After incubation with HRP labelled secondary antibody, wells were aspirated and washed 3 times. With the addition of substrate solution, wells were incubated 15-25 minutes at 37. Finally, add 50uL stop solution to the wells and read at 450nm immediately. The binding activity of TP53 and CREBBP was shown in Figure 1, and this effect was in a dose dependent manner.Figure. The binding activity of TP53 with CREBBP.)
Tumor Protein p53, Active Protein (Cat# AAA150105)
Full Name
Active Tumor Protein p53 (P53)
Gene Names
Tp53; p53; Trp53
Applications
Activity Assay, Cell Culture
Purity
>97%
Pricing
Bioactivity
(Figure 1. The binding activity of FABP4 with ACTb)
Fatty Acid Binding Protein 4, Active Protein (Cat# AAA150114)
Full Name
Active Fatty Acid Binding Protein 4 (FABP4)
Gene Names
FABP4; aP2; ALBP; AFABP; A-FABP; HEL-S-104
Applications
Activity Assay, Cell Culture
Purity
>90%
Pricing
Application Data
(Figure. Inhibition of 3T3 cell proliferation after stimulated with GREM1.)
Gremlin 1, Active Protein (Cat# AAA150126)
Full Name
Active Gremlin 1 (GREM1)
Gene Names
GREM1; DRM; HMPS; MPSH; PIG2; CRAC1; CRCS4; DAND2; HMPS1; IHG-2; DUP15q; C15DUPq; GREMLIN; CKTSF1B1
Applications
Activity Assay, Cell Culture
Purity
>97%
Pricing
Application Data
KGF (FGF7), Active Protein (Cat# AAA214319)
Full Name
Recombinant Mouse KGF (FGF7)
Gene Names
Fgf7; Kgf
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
(Measured by its binding ability in a functional ELISA. Immobilized Mouse ACVR2B at 2ug/mL (100 ul/well) can bind biotinylated mouse INHBA-His, The EC50 of biotinylated mouse INHBA-His is 40-95 ng/mL.)
ACVR2B, Active Protein (Cat# AAA258137)
Full Name
ACVR2B Protein, Mouse, Recombinant (His Tag)
Gene Names
Acvr2b; ActRIIB
Purity
>94% as determined by SDS-PAGE
Pricing
Application Data
(Measured in a cell proliferation assay using BALB/c 3T3 mouse fibroblasts. The ED50 for this effect is typically 0.8-3.3 ug/mL.)
FGF8, Active Protein (Cat# AAA258049)
Full Name
FGF8 Protein, Human, Recombinant
Gene Names
FGF8; HH6; AIGF; KAL6; FGF-8; HBGF-8
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
(Immobilized human ACE2 protein (mFc tag) at 2 ug/mL (100 uL/well) can bind SARS-CoV-2 Spike S1+S2 (D80A, LAL242-244 deletion, R246I, K417N, E484K, N501Y, D614G, A701V) Protein (ECD, His Tag),the EC50 of SARS-CoV-2 Spike S1+S2 (D80A, LAL242-244 deletion, R246I, K417N, E484K, N501Y, D614G, A701V) Protein (ECD, His Tag) is 100-600 ng/mL.)
COVID 19 Spike S1+S2 (D80A, LAL242-244 deletion, R246I, K417N, E484K, N501Y, D614G, A701V) Protein (ECD, His Tag) Coronavirus, Active Protein (Cat# AAA258077)
Full Name
SARS-CoV-2 Spike S1+S2 (D80A, LAL242-244 deletion, R246I, K417N, E484K, N501Y, D614G, A701V) Protein (ECD, His Tag)
Purity
>85% as determined by SDS-PAGE
Pricing
Application Data
(Measured by its binding ability in a functional ELISA.Immobilized human ACE2 protein (Fc tag)(10108-H05H) at 2 ug/mL (100 uL/well) can bind SARS-CoV-2 (2019-nCoV) Spike S1+S2 ECD (D614G)-His(40589-V08B4), the EC50 of SARS-CoV-2 (2019-nCoV) Spike S1+S2 ECD (D614G)-His(40589-V08B4) is 0.5-1.2 ug/mL.)
COVID 19 Spike S1+S2 ECD (D614G)-His Coronavirus, Active Protein (Cat# AAA258079)
Full Name
SARS-CoV-2 (2019-nCoV) Spike S1+S2 ECD (D614G)-His Recombinant Protein
Purity
>90% as determined by SDS-PAGE
Pricing
Bioactivity
(The cytochrome P450 enzyme CYP2E1 catalyzes the oxidative metabolism of many solvents and other small organic molecules. CYP2E1 is expressed in adult and fetal human liver in addition to extrahepatic tissues such as lung and placenta. Treatment of primary cultures of human hepatocytes with ethanol induces CYP2E1 protein, and this is consistent with the finding that hepatic CYP2E1 protein and mRNA levels are increased in individuals with alcoholism. Although only a few drugs (e.g., acetaminophen have been identified as substrates for CYP2E1, many low molecular weight procarcinogens are activated by this cytochrome P450 (P450). Chlorzoxazone 6-hydroxylation, N-nitrosodimethylamine N-demethylation and p-nitrophenol hydroxylation can be used to measure the catalytic activity of CYP2E1. Thus, the recombinant human CYP2E1 activity was measured by its ability to hydroxylate p-nitrophenol to p-nitrocatechol. The reaction was performed in 50 mM potassium phosphate, pH 7.4 (Assay Buffer), initiated by addition 20 uL of 500 ug/ml CYP2E1 to 10 uL of 5 mM substrate p-nitrophenol and 30 ul of 26 mM NADPH in a total volume of 500 ul. Incubated at 37 degree C for 30min, then read at a wavelength of 535 nm after acidification of the reaction mixture with trichloroacetic acid followed by neutralization using 2 M NaOH.)
Cytochrome P450 2E1 (CYP2E1), Active Protein (Cat# AAA161816)
Full Name
Active Cytochrome P450 2E1 (CYP2E1)
Gene Names
CYP2E1; CPE1; CYP2E; P450-J; P450C2E
Applications
Activity Assay, Cell Culture
Purity
Greater than 90% by SDS-PAGE
Pricing
SDS-PAGE
(Recombinant SARS-CoV-2 S1+S2 trimer Protein (C-His Tag)(Omicron))
COVID 19 Spike S1+S2 trimer Coronavirus, Active Protein (Cat# AAA177998)
Full Name
Recombinant SARS-CoV-2 S1+S2 trimer Protein (C-His Tag)(Omicron)
Purity
>95% as determined by SDS-PAGE.
Pricing
SDS-PAGE
COVID 19 Spike RBD Coronavirus, Active Protein (Cat# AAA177012)
Full Name
Recombinant 2019-nCoV Spike Protein (RBD)
Purity
> 90 % as determined by reducing SDS-PAGE.
Pricing
BCA1, Active Protein (Cat# AAA75198)
Full Name
BCA1 protein
Gene Names
CA1; ARABIDOPSIS THALIANA SALICYLIC ACID-BINDING PROTEIN 3; ATBCA1; ATSABP3; BETA CARBONIC ANHYDRASE 1; CA1; carbonic anhydrase 1; F4P13.5; F4P13_5; SABP3; SALICYLIC ACID-BINDING PROTEIN 3
Purity
> 98% pure
Pricing
IGF1, Active Protein (Cat# AAA75399)
Full Name
IGF1 protein
Gene Names
IGF1; IGFI; IGF-I; IGF1A
Purity
> 98% pure
Pricing
Chymase, Active Protein (Cat# AAA75403)
Full Name
Chymase reagent
Gene Names
CMA1; CYH; MCT1; chymase
Purity
> 95% by SDS-PAGE and gel diffusion
Pricing
Interferon Tau, Active Protein (Cat# AAA75447)
Full Name
Purified recombinant Bovine IFN-Tau protein (Bovine)
Reactivity
Bovine
Purity
>=95% pure
Pricing
Insulin, Active Protein (Cat# AAA75245)
Full Name
Insulin protein
Gene Names
INS; IDDM; ILPR; IRDN; IDDM1; IDDM2; MODY10
Purity
> 99% pure
Pricing
Hepatocyte Growth Factor, Active Protein (Cat# AAA38133)
Full Name
Recombinant Human Hepatocyte Growth Factor, CHO
Gene Names
HGF; SF; HGFB; HPTA; F-TCF; DFNB39
Purity
Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Pricing
Vascular Endothelial Growth Factor, Active Protein (Cat# AAA38137)
Full Name
Recombinant Human Vascular Endothelial Growth Factor, CHO
Gene Names
VEGFA; VPF; VEGF; MVCD1
Purity
Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Pricing
Insulin Like Growth Factor Binding Protein-3, Active Protein (Cat# AAA38150)
Full Name
Recombinant Human Insulin Like Growth Factor Binding Protein-3
Gene Names
IGFBP3; IBP3; BP-53
Purity
Greater than 97.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Pricing
Growth and Differentiation factor 15, Active Protein (Cat# AAA38164)
Full Name
Recombinant Human Growth and Differentiation factor 15
Gene Names
GDF15; PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15
Purity
Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Pricing
Leptin, Active Protein (Cat# AAA38172)
Full Name
Recombinant Mouse Leptin
Gene Names
Lep; ob; obese
Purity
Greater than 95.0% as determined by: (a) Analysis by SEC-HPLC. (b) Analysis by SDS-PAGE.
Pricing
Growth and Differentiation factor 5, Active Protein (Cat# AAA38207)
Full Name
Recombinant Human Growth and Differentiation factor 5
Gene Names
GDF5; OS5; LAP4; BDA1C; BMP14; CDMP1; LAP-4; SYM1B; SYNS2; BMP-14
Purity
Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Pricing
KBP-Type Peptidyl-Prolyl Cis-Trans Isomerase, Active Protein (Cat# AAA38285)
Full Name
Recombinant E Coli KBP-Type Peptidyl-Prolyl Cis-Trans Isomerase
Gene Names
slyD; ECK3336; JW3311
Purity
Greater than 95.0% as determined by SDS-PAGE.
Pricing
Follicle Stimulating Hormone, Active Protein (Cat# AAA38350)
Full Name
Recombinant Human Follicle Stimulating Hormone
Purity
Greater than 95.0% as determined by SDS-PAGE.
Pricing
Purity Info
PDE7A, Active Protein (Cat# AAA72929)
Full Name
PDE7A, Active recombinant protein
Gene Names
PDE7A; HCP1; PDE7
Purity
>90%
Pricing
Application Data
CDC7/DBF4, Active Protein (Cat# AAA72963)
Full Name
CDC7/DBF4, Active
Gene Names
CDC7; Hsk1; CDC7L1; HsCDC7; huCDC7
Applications
Western Blot
Purity
>85%
Pricing
Purity Data
(Sample Purity Data.)
COVID 19 NSP10/NSP16 Methyltransferase Coronavirus, Active Protein (Cat# AAA73168)
Full Name
2019-nCoV NSP10/NSP16 Methyltransferase, Active
Pricing
Mitogen-Activated Protein Kinase 1, Active Protein (Cat# AAA38388)
Full Name
Recombinant Human Mitogen-Activated Protein Kinase 1, Active
Gene Names
MAPK1; ERK; p38; p40; p41; ERK2; ERT1; ERK-2; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; p42-MAPK
Purity
The purity is greater than 95%.
Pricing
Vascular Endothelial Growth Factor receptor-1, Active Protein (Cat# AAA38398)
Full Name
Recombinant Human Vascular Endothelial Growth Factor receptor-1
Gene Names
FLT1; FLT; FLT-1; VEGFR1; VEGFR-1
Purity
Greater than 90.0% as determined by(a)Analysis by RP-HPLC. (b)Analysis by SDS-PAGE.
Pricing
Superoxide Dismutase-1, Active Protein (Cat# AAA38724)
Full Name
Recombinant Human Superoxide Dismutase-1
Gene Names
SOD1; ALS; SOD; ALS1; IPOA; hSod1; HEL-S-44; homodimer
Purity
Greater than 95.0% as determined by SDS-PAGE.
Pricing
IL-32 alpha, Active Protein (Cat# AAA38596)
Full Name
Recombinant Human IL-32 alpha
Gene Names
IL32; NK4; TAIF; TAIFa; TAIFb; TAIFc; TAIFd; IL-32beta; IL-32alpha; IL-32delta; IL-32gamma
Purity
Greater than 97.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Pricing
Glutathione S-Transferase, Active Protein (Cat# AAA38680)
Full Name
Recombinant Glutathione S-Transferase
Purity
Greater than 95% as determined by SDS-PAGE.
Pricing
Thioredoxin Reductase 1, Active Protein (Cat# AAA38824)
Full Name
Recombinant Human Thioredoxin Reductase 1
Gene Names
TXNRD1; TR; TR1; TXNR; TRXR1; GRIM-12
Purity
Greater than 90% as determined by SDS-PAGE.
Pricing
Lactate Dehydrogenase 2, Active Protein (Cat# AAA44810)
Full Name
Lactate Dehydrogenase 2 (LDH-2), Human Erythrocytes
Pricing
Interleukin 4, Active Protein (Cat# AAA62204)
Full Name
Human Interleukin 4 (IL-4), yeast
Gene Names
IL4; BSF1; IL-4; BCGF1; BSF-1; BCGF-1
Purity
> or = 97% purity (by SDS-PAGE and HPLC)
Pricing
BETA GALACTOSIDASE, Active Protein (Cat# AAA50519)
Full Name
NATIVE ESCHERICHIA COLI BETA GALACTOSIDASE
Gene Names
lacZ; ECK0341; JW0335
Applications
Functional Assay
Pricing
Creatine Kinase BB (CK-BB) Recombinant, Active Protein (Cat# AAA58337)
Full Name
CK-BB, Recombinant
Gene Names
CKB; B-CK; CKBB
Applications
ELISA
Purity
>95% pure (SDS-PAGE). Purified under non-denaturing conditions.
Pricing
What Are Active Proteins?
Proteins are large molecules made up of long chains of amino acids.
They will typically fold into a very particular 3-dimensional shape/conformation, that is sometimes referred to as their “native” form, which allows them to work properly in the body. For the purposes of product categorization, AAA Biotech will typically refer to proteins purified from their original animal host as being “native” proteins (this is to signify their difference compared to their “recombinant” or “synthetic” protein counterparts).
If a protein successfully folds into the correct shape, it is will typically display high fidelity characteristics to its original protein in its original animal host, and be classified as an active protein, as it will be able to function “normally” in most enzymatic or binding capacities. If it loses this shape, due to factors such as heat or strong chemicals (such as detergents), it becomes inactive and is no longer able to perform its basic functions. All of the proteins in this category are made under strict quality control, and they are active, pure, low in contaminants, and stable.
Most are stored as freeze-dried powders and come without extra tags, so they’re very close to the actual natural/native form.
Key Applications of Active Proteins
1. Scientific Research
- Aid in the study of how proteins function in the body
- Aid in understanding various disease processes
2. Drug Development
- Powerful tools to investigate how potential drugs interact with specific proteins
- Ideal for identifying drug targets
3. Cell Culture
- Are routinely utilized to support cell growth and function (e.g., using exogenous growth factors)
- Can be used to promote cellular development into specific types (differentiation)
4. Diagnostics
- Regularly utilized in tests to detect diseases or infections (e.g., COVID-19, cancer)
- Note: All products are strictly for research-use only (RUO).
5. Therapeutics
- Some active proteins are used directly as treatments (e.g., insulin, enzymes)
- Note: All products are strictly for research-use only (RUO).
6. Vaccine Development
- Used to create or test vaccines by mimicking parts of viruses or bacteria
7. Biochemical Assays
- They can facilitate the characterization of enzyme activity, binding strength, or protein interactions in lab tests
Why Buy Active Proteins from AAA Biotech?
- High biological activity – Verified to perform as expected or indicated on datasheet
- Strict quality control – We are confident in our active proteins’ reliability and consistency
- High purity & low endotoxin – Ideal for applications involving sensitive or precious samples/components
- Freeze-dried for stability – Long shelf life and straightforward storage
- Mostly tag-free – Closer to natural/native protein form
FAQ
1. What are active proteins used for in research?
Active proteins are used primarily in the study of how proteins function, in characterizing/discovering drug interactions, supporting cell growth, running biochemical assays, and in development of diagnostics or therapeutics.
2. How are AAA Biotech's active proteins validated?
AAA Biotech’s active proteins are validated through strict quality control and functional assays to ensure they are properly folded and active. “Active”, though, can be an ambiguous term, so if a specific “activity” or “binding” capability of a protein is of crucial interest to you, please inquire with us prior to purchase, and we will provide further details on how the “Active” modifier was determined to be applicable.
3. Are these proteins tested for biological activity?
Yes, all active proteins from AAA Biotech are tested to confirm they have the expected biological activity before being offered for use. Though, said “biological activity” can be either “enzymatic”, “binding”, or both.