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▼Active Proteins
AAA Biotech also known as AAA Bio or AAABio provides a variety of high-quality recombinant and natural/native proteins that are proven to work in a wide range of experiments. Explore our products to find the active protein that best fits your needs or experimental model.
Viewing 550-600 of 2583 product results
Interleukin-3, Active Protein (Cat# AAA38970)
Full Name
Recombinant Rhesus Macaque Interleukin-3
Gene Names
IL3; IL-3; MCGF; MULTI-CSF
Purity
Greater than 97.0% as determined by SDS-PAGE.
Pricing
GST T1-1, Active Protein (Cat# AAA71852)
Full Name
GST T1-1, Recombinant Human
Purity
>= 95% as assessed by inspection on a Coomassie Blue-stained SDS-PAGE gel.
Pricing
Cancer Antigen 72-4, Active Protein (Cat# AAA44847)
Full Name
Cancer Antigen 72-4 (CA 72-4), Human
Purity
>= 90% (SDS-PAGE)
Pricing
Elastase (ELA-2), Active Protein (Cat# AAA44742)
Full Name
Elastase (ELA-2), Human Neutrophils
Purity
> 96% (SDS-PAGE. Multiple bands observed)
Pricing
Application Data
(Measured by its binding ability in a functional ELISA. Immobilized human APOH-his at 2 ug/mL (100 ul/well) can bind biotinylated mouse LDLR-his, The EC50 of biotinylated mouse LDLR-his is 26 ng/mL.)
Apolipoprotein H, Active Protein (Cat# AAA257970)
Full Name
Apolipoprotein H Protein, Human, Recombinant (His Tag)
Gene Names
APOH; BG; B2G1; B2GP1
Purity
>96% as determined by SDS-PAGE
Pricing
Application Data
(Measured by its binding ability in a functional ELISA. Immobilized human TDGF1 at 2 ug/ml (100 ul/well) can bind human ALK-4 with a linear range of 0.032-4 ug/ml.)
ALK4/ACVR1B, Active Protein (Cat# AAA257899)
Full Name
ALK4/ACVR1B Protein, Human, Recombinant (His Tag)
Gene Names
ACVR1B; ALK4; SKR2; ACTRIB; ACVRLK4
Purity
>92% as determined by SDS-PAGE
Pricing
Application Data
(Measured by its ability to inhibit BMP9 induced alkaline phosphatase production by MC3T3E1 mouse chondrogenic cells. David, L. et al. (2007) Blood 109:1953. The ED50 for this effect is typically 50-200 ng/mL in the presence of 2 ng/mL of recombiant human BMP9.)
ALK-1, Active Protein (Cat# AAA257826)
Full Name
ALK-1 Protein, Human, Recombinant (His Tag)
Gene Names
ACVRL1; HHT; ALK1; HHT2; ORW2; SKR3; ALK-1; TSR-I; ACVRLK1
Purity
>92% as determined by SDS-PAGE
Pricing
Application Data
(Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 0.3-2 ug/mL in the presence of 10 ng/mL recombinant Activin A.)
ACVR2B, Active Protein (Cat# AAA257850)
Full Name
ACVR2B Protein, Human, Recombinant (His Tag)
Gene Names
ACVR2B; HTX4; ACTRIIB; ActR-IIB
Purity
>97% as determined by SDS-PAGE
Pricing
Application Data
(Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 0.2-1 ug/mL in the presence of 10 ng/mL recombinant Activin A.)
ACVR2B, Active Protein (Cat# AAA258265)
Full Name
ACVR2B Protein, Cynomolgus, Recombinant (His Tag)
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
(Measured by its binding ability in a functional ELISA. Immobilized Mouse Angiopoietin-2-His at 2 ug/ml (100 ul/well) can bind mouse TEK-Fc, the EC50 of mouse TEK-Fc is 350-900 ng/mL.)
Angiopoietin-2, Active Protein (Cat# AAA258152)
Full Name
Angiopoietin-2 Protein, Mouse, Recombinant (His Tag)
Gene Names
Angpt2; Ang2; Agpt2; Ang-2
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
(Measured in a cell proliferation assay using BALB/c 3T3 mouse fibroblasts. The ED50 for this effect is typically 0.4-1.6 ug/mL.)
FGF8, Active Protein (Cat# AAA258053)
Full Name
FGF8 Protein, Human, Recombinant
Gene Names
FGF8; HH6; AIGF; KAL6; FGF-8; HBGF-8
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
(Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 0.6-3 ug/mL in the presence of 10 ng/ml Recombinant Human Activin A.)
ACVR2A, Active Protein (Cat# AAA258185)
Full Name
ACVR2A Protein, Mouse, Recombinant (His Tag)
Gene Names
Acvr2a; Acvr2; ActrIIa; TactrII
Purity
>97% as determined by SDS-PAGE
> 95% as determined by SEC-HPLC
> 95% as determined by SEC-HPLC
Pricing
Bioactivity
Angiotensin-converting enzyme (ACE2), Active Protein (Cat# AAA244034)
Full Name
Recombinant Macaca fascicularis Angiotensin-converting enzyme (ACE2), partial
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Pricing
Bioactivity
Membrane Cofactor (CD46), Active Protein (Cat# AAA243727)
Full Name
Recombinant Human Membrane Cofactor Protein (CD46)
Gene Names
CD46; MCP; TLX; AHUS2; MIC10; TRA2.10
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Pricing
Application Data
(Transforming growth factor beta (TGF-) is a multifunctional cytokine belonging to the transforming growth factor superfamily. The TGF- superfamily includes endogenous growth inhibiting proteins; an increase in expression of TGF- often correlates with the malignancy of many cancers and a defect in the cellular growth inhibition response to TGF-. Its immunosuppressive functions then come to dominate, contributing to oncogenesis. To test the effect of TGF- on inhibit HGF-dependent proliferation, HepG2 cells were seeded into triplicate wells of 96-well plates at a density of 2,000 cells/well and allowed to attach, replaced with serum-free overnight, then the medium was replaced with 2% serum standard DMEM including 1ng/mL HGF prior to the addition of various concentrations of recombinant human TGF-. After incubated for 96h, cells were observed by inverted microscope and cell proliferation was measured by Cell Counting Kit-8 (CCK-8). Briefly, 10uL of CCK-8 solution was added to each well of the plate, then the absorbance at 450nm was measured using a microplate reader after incubating the plate for 1-4 hours at 37. The inhibitory effect of TGF- on HGF-dependent proliferation of HepG2 cells observed by inverted microscope was shown in Figure 2. Cell viability was assessed by CCK-8 assay after incubation with recombinant TGF- for 96h. The result was shown in Figure 3. It was obvious that TGF- significantly decreased cell viability of HepG2 cells. (A) HepG2 cells cultured in DMEM, stimulated with 1ug/mL TGF- for 96h; (B) Unstimulated HepG2 cells cultured in DMEM for 96h.Figure.The inhibitory effect of TGF- on cell proliferation of HepG2 cells.)
Transforming Growth Factor Beta 2, Active Protein (Cat# AAA150084)
Full Name
Active Transforming Growth Factor Beta 2 (TGFb2)
Gene Names
TGFB2; LDS4; G-TSF; TGF-beta2
Applications
Activity Assay, Cell Culture
Purity
>90%
Pricing
Bioactivity
Signal Transducer CD24/CD24, Active Protein (Cat# AAA177953)
Full Name
Recombinant Human Signal Transducer CD24/CD24 (C-mFC)
Gene Names
CD24; CD24A
Purity
>95% as determined by reducing SDS-PAGE
Pricing
Leptin (Anti-Obesity Protein) (rHuLeptin), Active Protein (Cat# AAA47954)
Full Name
Recombinant Human Leptin
Gene Names
lep; ob; xlep
Purity
Greater than 95% by RP-HPLC, anion-exchange chromatography; reducing and non-reducing SDS-PAGE, silver stain.
Purification: Chromatographic
Purification: Chromatographic
Pricing
Vascular Endothelial Growth Factor (rHuVEGF), Active Protein (Cat# AAA47955)
Full Name
Recombinant Human Vascular Endothelial Growth Factor
Gene Names
VEGFA; VPF; VEGF; MVCD1; MGC70609
Purity
Greater than 98% by RP-HPLC, anion-exchange chromatography; reducing and non-reducing SDS-PAGE, silver stain.
Purification: Chromatographic
Purification: Chromatographic
Pricing
Myostatin, Active Protein (Cat# AAA76059)
Full Name
Human Myostatin Recombinant
Purity
>97%, as determined by SDS-PAGE and HPLC
Pricing
Bioactivity
(Mouse M-CSF stimulates cell proliferation of the M-NFS-60 mouse myelogenous leukemia lymphoblast cells. The ED50 range is )
M-CSF, Active Protein (Cat# AAA48318)
Full Name
Recombinant M-CSF
Gene Names
Csf1; op; Csfm; MCSF; C87615
Applications
Bioactivity, SDS-PAGE
Purity
> 90% by SDS - PAGE
Pricing
Bioactivity
(Mouse TRANCE/RANK L/TNFSF11 stimulates osteoclast differentiation of the RAW 264.7 mouse monocyte/macrophage cells. The ED50 range )
TRANCE/RANK L/TNFSF11, Active Protein (Cat# AAA48324)
Full Name
Recombinant TRANCE/RANK L/TNFSF11
Gene Names
Tnfsf11; ODF; OPGL; RANKL; Ly109l; Trance
Applications
Bioactivity, SDS-PAGE
Purity
> 90% by SDS - PAGE
Pricing
Bioactivity
(SARS-CoV-2 Spike S1 Subunit is coated at 5ug/ml (100 ul/well) can bind ACE-2 (CAT# ATGP3963) in a Functional ELISA assay.)
COVID 19 Spike S1 Subunit Coronavirus, Active Protein (Cat# AAA48370)
Full Name
Recombinant SARS-CoV-2 (2019-nCoV) Spike S1 Subunit protein
Applications
Bioactivity, SDS-PAGE
Purity
>85% by SDS-PAGE
Pricing
Bioactivity
(SARS-CoV Spike is coated at 5ug/ml (100 ul/well) can bind ACE-2 (CAT# ATGP3963) in a Functional ELISA assay.)
COVID 19 Spike Coronavirus, Active Protein (Cat# AAA48375)
Full Name
Recombinant SARS-CoV Spike protein
Applications
Bioactivity, SDS-PAGE
Purity
>85% by SDS-PAGE
Pricing
Bioactivity
(SARS-CoV-2 Spike RBD is coated at 5ug/ml (100 ul/well) can bind ACE-2 (CAT# ATGP3963) in a Functional ELISA assay.)
COVID 19 Spike RBD Coronavirus, Active Protein (Cat# AAA48377)
Full Name
Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD protein
Applications
Bioactivity, SDS-PAGE
Purity
>95% by SDS-PAGE
Pricing
Bioactivity
(Canine IL-21 stimulates IFN-g secretion of the NK-92 human natural killer cells. The ED50 range )
IL-21, Active Protein (Cat# AAA48379)
Full Name
Recombinant canine IL-21 protein
Gene Names
IL21; IL-21
Applications
Bioactivity, SDS-PAGE
Purity
>95% by SDS-PAGE
Pricing
Bioactivity
(Human SARS-CoV-2 Spike RBD is coated at 5ug/ml (100 ul/well) can bind ACE-2 (CAT# ATGP3963) in a Functional ELISA assay)
COVID 19 Spike RBD Coronavirus, Active Protein (Cat# AAA48384)
Full Name
Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD protein
Applications
Bioactivity, SDS-PAGE
Purity
>95% by SDS-PAGE
Pricing
SDS-PAGE
(3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.)
PAI-1, Active Protein (Cat# AAA48474)
Full Name
PAI-1, 24-402aa, Human, His tag, E Coli (Bioactivity Validated)
Gene Names
SERPINE1; PAI; PAI1; PAI-1; PLANH1
Applications
Enzyme Activity, SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
SDS-PAGE
Interleukin-4, Active Protein (Cat# AAA48531)
Full Name
Interleukin- 4, 25-153aa, Human, His tag, E Coli (Bioactivity Validated)
Gene Names
IL4; BSF1; IL-4; BCGF1; BSF-1; BCGF-1
Applications
SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
ELISA
(Biotinylated TGFB-1 ELISAImmobilized Biotinylated Human TGF Beta1 at 1ug/ml (100ul/Well). Response curve for TGFR2 with alinear range of 2-100 ng/ml was determined by ELISA)
TGF Beta-1, Active Protein (Cat# AAA76386)
Full Name
Biotinylated Human TGF Beta-1 Recombinant
Gene Names
TGFB1; CED; LAP; DPD1; TGFB; TGFbeta
Purity
>90%, as determined by SDS-PAGE and HPLC
Pricing
SDS-PAGE
(3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.)
Osteopontin/OPN protein, Active Protein (Cat# AAA48974)
Full Name
Recombinant human Osteopontin/OPN protein
Applications
Bioactivity, SDS-PAGE
Purity
> 90% by SDS-PAGE
Pricing
OX40/TNFRSF4, Active Protein (Cat# AAA48994)
Full Name
Recombinant mouse OX40/TNFRSF4 protein
Gene Names
Tnfrsf4; Ox40; ACT35; CD134; Ly-70; Txgp1; TXGP1L
Applications
Bioactivity, SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
Flt3 ligand/FLT3LG, Active Protein (Cat# AAA49008)
Full Name
Recombinant human Flt3 ligand/FLT3LG protein
Gene Names
FLT3LG; FL; FLG3L; FLT3L
Applications
Bioactivity, SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
Bioactivity
(Human IL-17E/IL-25 is coated at 2 ug/ml (100 ul/well) can bind Human IL-17 RB (CAT# ATGP4039) in a Functional ELISA assay.)
IL-17E/IL-25, Active Protein (Cat# AAA48395)
Full Name
Recombinant human IL-17E/IL-25 protein
Gene Names
IL25; IL17E
Applications
Bioactivity, SDS-PAGE
Purity
>95% by SDS-PAGE
Pricing
Bioactivity
(Mouse OX40 Ligand/TNFSF4 (CAT# ATGP4022) is coated at 1 ug/ml (100 ul/well) can bind Human TNFRSF4. The ED50 range )
OX40/TNFRSF4, Active Protein (Cat# AAA48407)
Full Name
Recombinant human OX40/TNFRSF4 protein
Gene Names
TNFRSF4; OX40; ACT35; CD134; IMD16; TXGP1L
Applications
Bioactivity, SDS-PAGE
Purity
>90% by SDS-PAGE
Pricing
SDS-PAGE
(Figure 1. Human BAFF-R Protein, mFc Tag on SDS-PAGE under reducing condition.)
BAFF-R, Active Protein (Cat# AAA47223)
Full Name
Recombinant Human BAFF-R protein with C-terminal mouse Fc
Gene Names
TNFRSF13C; BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin
Applications
Western Blot
Purity
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Pricing
Application Data
PDGF-AB, Active Protein (Cat# AAA79253)
Full Name
Human PDGF-AB
Gene Names
PDGFA; PDGF1; PDGF-A
Reactivity
Human
Purity
> 95% by SDS-PAGE & silver stain
Pricing
ELISA
(Functional ELISA to test the binding of sTIE-2 to its ligand Ang-2. Ang-2 was coated on the plate and increasing amounts of recombinant human soluble sTIE-2 was added)
TIE-2, soluble, Active Protein (Cat# AAA79307)
Full Name
Human TIE-2, soluble
Gene Names
TEK; TIE2; VMCM; TIE-2; VMCM1; CD202B
Reactivity
Human
Purity
> 95% by SDS-PAGE & silver stain
Pricing
Application Data
VEGF-C, Active Protein (Cat# AAA79180)
Full Name
Rat VEGF-C
Reactivity
Rat
Purity
> 90% by SDS-PAGE & silver stain
Pricing
Application Data
FGF-2 (basic), Active Protein (Cat# AAA79225)
Full Name
Rat FGF-2 (basic)
Gene Names
Fgf2; bFGF; Fgf-2
Reactivity
Rat
Purity
> 98% by SDS-PAGE & silver stain
Pricing
Bioactivity
(HTRF assay for RPS6KA1/RSK1 activity 1 uM STK S1 substrate was incubated with different concentrations of RPS6KA1/RSK1 protein in 10 ul reaction system containing 1×Enzymatic Buffer, 5 mM MgCl2, 1 mM DTT, and 100 uM ATP for 1 hour. The detection reagents were added and incubated with the reactions for 30 min. All operations and reactions were performed at room temperature, and HTRF assay was used to detect the enzymatic activity.)
RPS6KA1/RSK1, Active Protein (Cat# AAA60316)
Full Name
Recombinant RPS6KA1/RSK1 protein
Purity
>=90%
Pricing
Bioactivity
(HTRF Assay for Recombinant PHKG2 activity. 1 uM STK S1 substrate was incubated with different concentrations of PHKG2 protein in 10 ul reaction system containing 1×Enzymatic Buffer, 10 mM MgCl2, 1 mM DTT and 100 uM ATP for 1 hour. The 10 ul detection reagents containing anti-STK antibody (1:2) and SA-XL665 (1:100) diluted with 1× Detection Buffer were added and incubated with the reactions for 30 min. All the operations and reactions were performed at room temperature. HTRF assay was used for detection.)
Bioactivity
(HTRF Assay for Recombinant BRD2 (BD1+BD2) activity. 3 uM histone peptide H4K5/8/12/16(ac4) was incubated with BRD2 (BD1+BD2) in reaction buffer including 50 mM HEPES-NaOH pH 7.0, 0.1% BSA for 1 hour at room temperature. Anti-His antibody was used to detect reaction products.)
BRD2 (BD1+BD2), Active Protein (Cat# AAA60342)
Full Name
Recombinant BRD2 (BD1+BD2) protein
Purity
>=85%
Pricing
Application Data
Growth Differentiation Factor 15 (hGDF15), Active Protein (Cat# AAA60567)
Full Name
Recombinant Human Growth Differentiation Factor 15 (hGDF15)
Purity
>95%, determined by SDS-PAGE
Pricing
IGF-I, Active Protein (Cat# AAA60570)
Full Name
Fish (denis) IGF-I
Gene Names
IGF1; IGFI; IGF-I; IGF1A
Purity
Greater than 98.0% as determined by:
(a) Analysis by reducing and non-reducing SDS-PAGE gel.
(b) Gel-filtration chromatography under non denaturing conditions.
(a) Analysis by reducing and non-reducing SDS-PAGE gel.
(b) Gel-filtration chromatography under non denaturing conditions.
super leptin antagonist, Active Protein (Cat# AAA60573)
Full Name
Rat super leptin antagonist (mutant D23/L39A/D40A/F41A)
Purity
The purity of super rat leptin antagonist is greater than 98.0% as determined by:
(a) Gel filtration analysis.
(b) Analysis by reducing and non-reducing SDS-PAGE gel.
(a) Gel filtration analysis.
(b) Analysis by reducing and non-reducing SDS-PAGE gel.
GST A3-3, Active Protein (Cat# AAA71844)
Full Name
GST A3-3, Recombinant Rat
Gene Names
GSTA3; GTA3; GSTA3-3
Purity
> 95% as assessed by inspection on a Coomassie® Blue-stained SDS-PAGE gel.
Pricing
GST P1-1, Active Protein (Cat# AAA71845)
Full Name
GST P1-1, Recombinant Human
Purity
> 95% as assessed by inspection on a Coomassie® Blue-stained SDS-PAGE gel.
Pricing
HSV2 gG2, Active Protein (Cat# AAA75436)
Full Name
HSV2 gG2 protein
Applications
Western Blot
Purity
> 95% pure
Pricing
Follistatin, Active Protein (Cat# AAA75437)
Full Name
Follistatin protein
Gene Names
Fst; FS; AL033346
Purity
> 95% pure
Pricing
EPO, Active Protein (Cat# AAA75440)
Full Name
EPO protein
Gene Names
EPO; EP; MVCD2
Reactivity
Human
Purity
> 98% pure by SDS-PAGE analysis
Pricing
What Are Active Proteins?
Proteins are large molecules made up of long chains of amino acids.
They will typically fold into a very particular 3-dimensional shape/conformation, that is sometimes referred to as their “native” form, which allows them to work properly in the body. For the purposes of product categorization, AAA Biotech will typically refer to proteins purified from their original animal host as being “native” proteins (this is to signify their difference compared to their “recombinant” or “synthetic” protein counterparts).
If a protein successfully folds into the correct shape, it is will typically display high fidelity characteristics to its original protein in its original animal host, and be classified as an active protein, as it will be able to function “normally” in most enzymatic or binding capacities. If it loses this shape, due to factors such as heat or strong chemicals (such as detergents), it becomes inactive and is no longer able to perform its basic functions. All of the proteins in this category are made under strict quality control, and they are active, pure, low in contaminants, and stable.
Most are stored as freeze-dried powders and come without extra tags, so they’re very close to the actual natural/native form.
Key Applications of Active Proteins
1. Scientific Research
- Aid in the study of how proteins function in the body
- Aid in understanding various disease processes
2. Drug Development
- Powerful tools to investigate how potential drugs interact with specific proteins
- Ideal for identifying drug targets
3. Cell Culture
- Are routinely utilized to support cell growth and function (e.g., using exogenous growth factors)
- Can be used to promote cellular development into specific types (differentiation)
4. Diagnostics
- Regularly utilized in tests to detect diseases or infections (e.g., COVID-19, cancer)
- Note: All products are strictly for research-use only (RUO).
5. Therapeutics
- Some active proteins are used directly as treatments (e.g., insulin, enzymes)
- Note: All products are strictly for research-use only (RUO).
6. Vaccine Development
- Used to create or test vaccines by mimicking parts of viruses or bacteria
7. Biochemical Assays
- They can facilitate the characterization of enzyme activity, binding strength, or protein interactions in lab tests
Why Buy Active Proteins from AAA Biotech?
- High biological activity – Verified to perform as expected or indicated on datasheet
- Strict quality control – We are confident in our active proteins’ reliability and consistency
- High purity & low endotoxin – Ideal for applications involving sensitive or precious samples/components
- Freeze-dried for stability – Long shelf life and straightforward storage
- Mostly tag-free – Closer to natural/native protein form
FAQ
1. What are active proteins used for in research?
Active proteins are used primarily in the study of how proteins function, in characterizing/discovering drug interactions, supporting cell growth, running biochemical assays, and in development of diagnostics or therapeutics.
2. How are AAA Biotech's active proteins validated?
AAA Biotech’s active proteins are validated through strict quality control and functional assays to ensure they are properly folded and active. “Active”, though, can be an ambiguous term, so if a specific “activity” or “binding” capability of a protein is of crucial interest to you, please inquire with us prior to purchase, and we will provide further details on how the “Active” modifier was determined to be applicable.
3. Are these proteins tested for biological activity?
Yes, all active proteins from AAA Biotech are tested to confirm they have the expected biological activity before being offered for use. Though, said “biological activity” can be either “enzymatic”, “binding”, or both.