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▼Active Proteins
AAA Biotech also known as AAA Bio or AAABio provides a variety of high-quality recombinant and natural/native proteins that are proven to work in a wide range of experiments. Explore our products to find the active protein that best fits your needs or experimental model.
Viewing 750-800 of 2583 product results
Bioactivity
(HTRF assay for MAP2K1 (MEK1) activity 1 uM TK substrate was incubated with different concentrations of MAP2K1 (MEK1) protein in 10 ul reaction system containing 1×Enzymatic Buffer, 5 mM MgCl2, 1 mM DTT, 5 nM SEB and 100 uM ATP for 1 hour. Then 10 ul detection reagents containing anti-TK antibody and SAXL665 (each of which was 1:100 diluted with 1× Detection Buffer) were added and incubated with the reactions for 30 min. All the operations and reactions were performed at room temperature. HTRF KinEASE TK assay was used to detect the enzymatic activity.)
MAP2K1 (MEK1), Active Protein (Cat# AAA60313)
Full Name
Recombinant MAP2K1 (MEK1) protein
Purity
>80%
Pricing
Bioactivity
(HTRF assay for RPS6KA2/RSK3 protein activity 1 uM STK S1 substrate was incubated with different concentrations of RPS6KA2/RSK3 protein in a 10 ul reaction system containing 1×Enzymatic Buffer, 5 mM MgCl2, 1 mM DTT, and 100 uM ATP for 1 hour. The 10 ul detection reagents containing anti-STK antibody (1:2) and SA-XL665 (1:100) diluted with 1× Detection Buffer were added and incubated with the reactions for 30 min. All the operations and reactions were performed at room temperature. HTRF assay was used for detection.)
RPS6KA2/RSK3, Active Protein (Cat# AAA60321)
Full Name
Recombinant RPS6KA2/RSK3 protein
Purity
>=90%
Pricing
Bioactivity
(HTRF Assay for Recombinant PRKD2 activity. 1 uM STK S1 substrate was incubated with different concentrations of PRKD2 protein in 10 ul reaction system containing 1×Enzymatic Buffer, 5 mM MgCl2, 1 mM DTT and 100 uM ATP for 1 hour. The 10 ul detection reagents containing anti-STK antibody (1:2) and SA-XL665 (1:100) diluted with 1× Detection Buffer were added and incubated with the reactions for 30 min. All the operations and reactions were performed at room temperature. HTRF assay was used for detection.)
Bioactivity
(HTRF Assay for Recombinant PLK1 activity. 1 uM STK S1 substrate was incubated with different concentrations of PLK1 protein in 10 ul reaction system containing 1×Enzymatic Buffer, 5 mM MgCl2, 1 mM DTT and 100 uM ATP for 1 hour. The 10 ul detection reagents containing anti-STK antibody (1:2) and SA-XL665 (1:100) diluted with 1× Detection Buffer were added and incubated with the reactions for 30 min. All the operations and reactions were performed at room temperature. HTRF assay was used for detection.)
SDS-PAGE
(3 ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.)
Beta-lactaminase, Active Protein (Cat# AAA48963)
Full Name
Beta-lactaminase, E Coli, 20-377, His-tag, E Coli (Bioactivity Validated)
Gene Names
ampC; ampA; ECK4146; JW4111
Applications
Enzyme Activity, SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
SDS-PAGE
(3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.)
IL15RA, Active Protein (Cat# AAA48968)
Full Name
IL15RA, 31-205aa, Human, hIgG-His-tag, Baculovirus
Gene Names
IL15RA; CD215
Applications
Bioactivity, SDS-PAGE
Purity
> 90% by SDS-PAGE
Pricing
Bioactivity
(MERS-CoV Spike RBD is coated at 2 ug/ml (100 ul/well) can bind human DPPIV/CD26 in a functional ELISA assay.)
MERS-CoV Spike, Active Protein (Cat# AAA48981)
Full Name
Recombinant MERS-CoV Spike RBD protein
Applications
Bioactivity, SDS-PAGE
Purity
> 90% by SDS-PAGE
Pricing
MERS-CoV Spike, Active Protein (Cat# AAA48982)
Full Name
Recombinant MERS-CoV Spike protein
Applications
Bioactivity, SDS-PAGE
Purity
> 85% by SDS-PAGE
Pricing
ICAM-1/CD54, Active Protein (Cat# AAA48983)
Full Name
Recombinant human ICAM-1/CD54 protein
Gene Names
ICAM1; BB2; CD54; P3.58
Applications
Bioactivity, SDS-PAGE
Purity
> 90% by SDS-PAGE
Pricing
Fc gamma RIIA/CD32a (R167H), Active Protein (Cat# AAA48984)
Full Name
Recombinant human Fc gamma RIIA/CD32a (R167H) protein
Gene Names
FCGR2A; CD32; FCG2; FcGR; CD32A; CDw32; FCGR2; IGFR2; FCGR2A1
Applications
Bioactivity, SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
EphA3, Active Protein (Cat# AAA48999)
Full Name
Recombinant mouse EphA3 protein
Gene Names
Epha3; Hek; Cek4; ETK1; End3; Hek4; Mek4; Tyro4; AW492086
Applications
Bioactivity, SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
Osteocrin, Active Protein (Cat# AAA49001)
Full Name
Recombinant Human Osteocrin protein
Gene Names
OSTN; MUSCLIN
Applications
Bioactivity, SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
SDS-PAGE
(3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain)
Cyclophilin A, Active Protein (Cat# AAA48477)
Full Name
Cyclophilin A, 1-165aa, Human, E Coli (Bioactivity Validated)
Gene Names
PPIA; CYPA; CYPH; HEL-S-69p
Applications
Enzyme Activity, SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
SDS-PAGE
G6PD, Active Protein (Cat# AAA48520)
Full Name
G6PD,1-491aa, E Coli, E Coli (Bioactivity Validated)
Gene Names
zwf; ECK1853; JW1841
Applications
SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
SDS-PAGE
(3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.)
Carbonic anhydrase 2, Active Protein (Cat# AAA48538)
Full Name
Carbonic anhydrase 2, 1-260aa, Human, E Coli (Bioactivity Validated)
Gene Names
CA2; CAC; CAII; Car2; CA-II; HEL-76; HEL-S-282
Applications
Enzyme Activity, SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
Application Data
(Biological Acitivity: Human IL-6 stimulates cell proliferation of the TF-1 human erythroleukemic cells. The ED50 range )
Interleukin 6, Active Protein (Cat# AAA48546)
Full Name
Interleukin 6, 30-212aa, Human, His tag, E Coli (Bioactivity Validated)
Gene Names
IL6; CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2
Applications
Bioactivity, SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
Bioactivity
(Human CD47 is coated at 1 ug/ml (100 ul/well) can bind Human SIRP gamma/CD172g (CAT# ATGP4030) in a Functional ELISA assay.)
CD47, Active Protein (Cat# AAA48392)
Full Name
Recombinant human CD47 protein
Gene Names
CD47; IAP; OA3; MER6
Applications
Bioactivity, SDS-PAGE
Purity
>95% by SDS-PAGE
Pricing
Bioactivity
(Mouse IL-21 stimulates IFN-g secretion of the NK-92 human natural killer cells. The ED50 range )
IL-21, Active Protein (Cat# AAA48409)
Full Name
Recombinant Mouse IL-21 Protein
Gene Names
Il21; IL-21
Applications
Bioactivity, SDS-PAGE
Purity
>90% by SDS-PAGE
Pricing
SDS-PAGE
NME2, Active Protein (Cat# AAA48916)
Full Name
NME2, 1-152aa, Human, E Coli (Bioactivity Validated)
Gene Names
NME2; PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2
Applications
Enzyme Activity, SDS-PAGE
Purity
> 90% by SDS-PAGE
Pricing
SDS-PAGE
SurA, Active Protein (Cat# AAA48603)
Full Name
SurA, 21-428aa, E Coli, His tag, E Coli (Bioactivity Validated)
Gene Names
surA; ECK0054; JW0052
Applications
SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
SDS-PAGE
(3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain)
LDHB, Active Protein (Cat# AAA48607)
Full Name
LDHB, 1-334aa, Human, His tag, E Coli (Bioactivity Validated)
Gene Names
LDHB; LDH-B; LDH-H; LDHBD; TRG-5; HEL-S-281
Applications
Enzyme Activity, SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
Bioactivity
(Human IL-6 R alpha inhibits Human IL-6 induced cell proliferation in the M1 mouse myeloid leukemia cells. The ED50 range 20 ng/ml.)
IL-6R alpha, Active Protein (Cat# AAA48327)
Full Name
Recombinant IL-6R alpha
Gene Names
IL6R; IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1
Applications
Bioactivity, SDS-PAGE
Purity
> 90% by SDS - PAGE
Pricing
Bioactivity
(Canine IL-1B stimulates cell proliferation of the D10.G4.1 mouse helper T cells. The ED50 range range )
IL-1 beta/IL-1F2, Active Protein (Cat# AAA48366)
Full Name
Recombinant canine IL-1 beta/IL-1F2 protein
Gene Names
IL1B; IL-1
Applications
Bioactivity, SDS-PAGE
Purity
>95% by SDS-PAGE
Pricing
Sonic Hedgehog, Active Protein (Cat# AAA75584)
Full Name
Sonic Hedgehog protein
Gene Names
Shh; Hx; Dsh; Hhg1; Hxl3; M100081; 9530036O11Rik
Purity
> 98% pure
Pricing
BD4, Active Protein (Cat# AAA75586)
Full Name
BD4 protein
Gene Names
DEFB104A; BD-4; DEFB4; hBD-4; DEFB-4; DEFB104
Purity
> 98% pure
Pricing
TLR3, Active Protein (Cat# AAA75594)
Full Name
TLR3 protein
Purity
>95% by SDS-PAGE gel and HPLC analysis
Pricing
ANGPTL-7, Active Protein (Cat# AAA76054)
Full Name
ANGPTL-7
Gene Names
ANGPTL7; AngX; CDT6; dJ647M16.1
Purity
>98%
IL2RA (CD25), Active Protein (Cat# AAA76070)
Full Name
Human IL2RA Recombinant (CD25)
Purity
>97%, as determined by SDS-PAGE and HPLC
Pricing
CD32b (FcgR2b), Active Protein (Cat# AAA76086)
Full Name
Human CD32b Recombinant (FcgR2b)
Purity
>95%, as determined by SDS-PAGE and HPLC
Pricing
EGFL7, Active Protein (Cat# AAA76105)
Full Name
Human EGFL7 Recombinant
Purity
>90%, as determined by SDS-PAGE
Pricing
Application Data
(KRAS G12V (HLA-A*03:01) Tetramer SPRSPR image shows curve for KRAS G12V(HLA-A*03:01) and immobilized Antibody binding, with a calculated affinity constant of 42nM)
HLA-A*03:01 KRAS G12V, Active Protein (Cat# AAA76371)
Full Name
HLA-A*03:01 KRAS G12V peptide Tetramer
Purity
purity was determined to be >95% by nonreducing PAGE and HPLC
Pricing
Application Data
(Polarized membrane extensions mediate osteoclast fusion.(D, top) Immunoblot analysis of lysates of RAW264.7 macrophages stimulated with RANKL for the indicated times with antibodies to Ser473-phosphorylated (p) or total forms of Akt.)
Soluble RANK ligand, Active Protein (Cat# AAA76384)
Full Name
Mouse Soluble RANK ligand Recombinant
Gene Names
Tnfsf11; ODF; OPG; OPGL; RANKL; Ly109l; Trance
Purity
>95%, as determined by SDS-PAGE and HPLC
Pricing
Application Data
(Generation of conditional TAK1-deficient mice.Colony formation by BM cells from Map3k7)
Granulocyte Colony Stimulating Factor, Active Protein (Cat# AAA76390)
Full Name
Mouse Granulocyte Colony Stimulating Factor Recombinant
Gene Names
Csf3; Csfg; G-CSF; MGI-IG
Purity
>95%, as determined by SDS-PAGE and HPLC
Pricing
Application Data
(Expression of programmed death-1 (PD-1) in macrophages/microglia after spinal cord injury (SCI) in mice.Immunohistochemistry in macrophages/microglia 14 days postinjury (dpi) in wild-type mice for (c) PD-1, (d) it’s ligand, PD-L1, and (e) PD-1 in M1 cells [inducible nitric oxide synthase (iNOS)+]; (f) PD-1 in M2 cells [arginase 1 (Arg1+)]; (g) PD-L1 in M1 cells (iNOS+); and (h) PD-L1 in M2 cells (Arg1+).)
PD-L1 (B7-H1), Active Protein (Cat# AAA76402)
Full Name
Human PD-L1 (B7-H1) Recombinant
Gene Names
Cd274; B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik
Purity
>95%, as determined by SDS-PAGE and HPLC
Pricing
Application Data
VEGF-E, Heparin-binding, Active Protein (Cat# AAA79120)
Full Name
Orf Virus VEGF-E, Heparin-binding
Reactivity
Orf virus
Purity
> 90% by SDS-PAGE & silver stain
Pricing
Application Data
LIF, Active Protein (Cat# AAA79124)
Full Name
Human LIF
Gene Names
LIF; CDF; DIA; HILDA; MLPLI
Reactivity
Human
Purity
> 98% by SDS-PAGE & silver stain
Pricing
Application Data
IL-2, Active Protein (Cat# AAA79197)
Full Name
Human IL-2
Gene Names
IL2; IL-2; TCGF; lymphokine
Reactivity
Human
Purity
> 98% by SDS-PAGE & silver stain
Pricing
FGFR-2/Fc Chimera, soluble, Active Protein (Cat# AAA79217)
Full Name
Human FGFR-2/Fc Chimera, soluble
Gene Names
FGFR2; BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM
Reactivity
Human
Purity
> 90% by SDS-PAGE & silver stain
Pricing
Application Data
PDGF-AA, Active Protein (Cat# AAA79228)
Full Name
Human PDGF-AA
Gene Names
PDGFA; PDGF1; PDGF-A
Reactivity
Human
Purity
> 95% by SDS-PAGE & silver stain
Pricing
Application Data
VEGF-F (Bothrops insularis), Active Protein (Cat# AAA79229)
Full Name
Snake VEGF-F (Bothrops insularis)
Reactivity
Snake
Purity
> 95% by SDS-PAGE & silver stain
Pricing
Application Data
VEGF144, Active Protein (Cat# AAA79241)
Full Name
Mouse VEGF144
Gene Names
Vegfa; Vpf; Vegf
Reactivity
Mouse
Purity
> 95% by SDS-PAGE & silver stain
Pricing
Application Data
VEGF121, Active Protein (Cat# AAA79263)
Full Name
Human VEGF121
Gene Names
VEGFA; VPF; VEGF; MVCD1
Reactivity
Human
Purity
> 98% by SDS-PAGE & silver stain
Pricing
Application Data
VEGF121, Active Protein (Cat# AAA79264)
Full Name
Human VEGF121
Gene Names
VEGFA; VPF; VEGF; MVCD1
Reactivity
Human
Purity
> 98% by SDS-PAGE & silver stain
Pricing
Endostatin, Active Protein (Cat# AAA79266)
Full Name
Human Endostatin
Gene Names
COL18A1; KS; KNO; KNO1
Reactivity
Human
Purity
98 % (SDS-PAGE, HPLC)
Pricing
Application Data
VEGF164, Active Protein (Cat# AAA79269)
Full Name
Mouse VEGF164
Gene Names
Vegfa; Vpf; Vegf
Reactivity
Mouse
Purity
> 95% by SDS-PAGE & silver stain
Pricing
Application Data
(In vitro: The proliferative response to recombinant rat VEGF-CC152S was assayed in VEGFR3-expressing porcine aortic endothelial (PAE) cells. Briefly, cells were plated in 12-well plates and incubated in DMEM medium supplemented with 1% fetal calf serum for cell cycle arrest 24h prior to stimulation of cell proliferation with recombinant VEGF-CC152S at the concentrations of 50 and 100 ng/mL. After 48h in culture, the cell proliferative response was assayed (WST-1 colorimetric assay), and the results expressed as % of control non-stimulated cells (mean + sem).)
VEGF-C152S, Active Protein (Cat# AAA79274)
Full Name
Rat VEGF-C152S
Reactivity
Rat
Purity
> 90% by SDS-PAGE & silver stain
Pricing
Application Data
FGF-4, Active Protein (Cat# AAA79291)
Full Name
Human FGF-4
Gene Names
FGF4; HST; KFGF; HST-1; HSTF1; K-FGF; HBGF-4
Reactivity
Human
Purity
> 95% by SDS-PAGE & silver stain
Pricing
Application Data
SCF, Active Protein (Cat# AAA79295)
Full Name
Human SCF
Gene Names
KITLG; SF; MGF; SCF; FPH2; KL-1; Kitl; SHEP7
Reactivity
Human
Purity
> 98% by SDS-PAGE & silver stain
Pricing
Application Data
FGF-2 (basic), Active Protein (Cat# AAA79309)
Full Name
Rat FGF-2 (basic)
Gene Names
Fgf2; bFGF; Fgf-2
Reactivity
Rat
Purity
> 98% by SDS-PAGE & silver stain
Pricing
Application Data
(Binding of recombinant human Wnt5a to recombinant human sROR2 in a functional ELISA. sROR2 was coated with 2ug/ml (100ug/well) and increasing amounts of Wnt5a was added. Detection was performed using a polyclonal rabbit anti-human Wnt5a and a goat anti-rabbit Biotin conjugated secondary antibody.)
ROR2, Active Protein (Cat# AAA79320)
Full Name
Human ROR2, soluble
Gene Names
ROR2; BDB; BDB1; NTRKR2
Reactivity
Human
Purity
> 98% by SDS-PAGE & Coomassie stain
Pricing
What Are Active Proteins?
Proteins are large molecules made up of long chains of amino acids.
They will typically fold into a very particular 3-dimensional shape/conformation, that is sometimes referred to as their “native” form, which allows them to work properly in the body. For the purposes of product categorization, AAA Biotech will typically refer to proteins purified from their original animal host as being “native” proteins (this is to signify their difference compared to their “recombinant” or “synthetic” protein counterparts).
If a protein successfully folds into the correct shape, it is will typically display high fidelity characteristics to its original protein in its original animal host, and be classified as an active protein, as it will be able to function “normally” in most enzymatic or binding capacities. If it loses this shape, due to factors such as heat or strong chemicals (such as detergents), it becomes inactive and is no longer able to perform its basic functions. All of the proteins in this category are made under strict quality control, and they are active, pure, low in contaminants, and stable.
Most are stored as freeze-dried powders and come without extra tags, so they’re very close to the actual natural/native form.
Key Applications of Active Proteins
1. Scientific Research
- Aid in the study of how proteins function in the body
- Aid in understanding various disease processes
2. Drug Development
- Powerful tools to investigate how potential drugs interact with specific proteins
- Ideal for identifying drug targets
3. Cell Culture
- Are routinely utilized to support cell growth and function (e.g., using exogenous growth factors)
- Can be used to promote cellular development into specific types (differentiation)
4. Diagnostics
- Regularly utilized in tests to detect diseases or infections (e.g., COVID-19, cancer)
- Note: All products are strictly for research-use only (RUO).
5. Therapeutics
- Some active proteins are used directly as treatments (e.g., insulin, enzymes)
- Note: All products are strictly for research-use only (RUO).
6. Vaccine Development
- Used to create or test vaccines by mimicking parts of viruses or bacteria
7. Biochemical Assays
- They can facilitate the characterization of enzyme activity, binding strength, or protein interactions in lab tests
Why Buy Active Proteins from AAA Biotech?
- High biological activity – Verified to perform as expected or indicated on datasheet
- Strict quality control – We are confident in our active proteins’ reliability and consistency
- High purity & low endotoxin – Ideal for applications involving sensitive or precious samples/components
- Freeze-dried for stability – Long shelf life and straightforward storage
- Mostly tag-free – Closer to natural/native protein form
FAQ
1. What are active proteins used for in research?
Active proteins are used primarily in the study of how proteins function, in characterizing/discovering drug interactions, supporting cell growth, running biochemical assays, and in development of diagnostics or therapeutics.
2. How are AAA Biotech's active proteins validated?
AAA Biotech’s active proteins are validated through strict quality control and functional assays to ensure they are properly folded and active. “Active”, though, can be an ambiguous term, so if a specific “activity” or “binding” capability of a protein is of crucial interest to you, please inquire with us prior to purchase, and we will provide further details on how the “Active” modifier was determined to be applicable.
3. Are these proteins tested for biological activity?
Yes, all active proteins from AAA Biotech are tested to confirm they have the expected biological activity before being offered for use. Though, said “biological activity” can be either “enzymatic”, “binding”, or both.