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▼Active Proteins
AAA Biotech also known as AAA Bio or AAABio provides a variety of high-quality recombinant and natural/native proteins that are proven to work in a wide range of experiments. Explore our products to find the active protein that best fits your needs or experimental model.
Viewing 1800-1850 of 2567 product results
Bioactivity
(Tumor protein p53 (TP53), also known as p53, cellular tumor antigen p53 has many mechanisms of anticancer function and plays a role in apoptosis, genomic stability, and inhibition of angiogenesis. TP53 act as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. It also Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. Besides, CREB Binding Protein (CREBBP) has been identified as an interactor of TP53, thus a binding ELISA assay was conducted to detect the interaction of recombinant rat TP53 and recombinant rat CREBBP. Briefly, TP53 were diluted serially in PBS, with 0.01% BSA (pH 7.4). Duplicate samples of 100L were then transferred to CREBBP-coated microtiter wells and incubated for 2h at 37. Wells were washed with PBST and incubated for 1h with anti-TP53 pAb, then aspirated and washed 3 times. After incubation with HRP labelled secondary antibody, wells were aspirated and washed 3 times. With the addition of substrate solution, wells were incubated 15-25 minutes at 37. Finally, add 50uL stop solution to the wells and read at 450nm immediately. The binding activity of TP53 and CREBBP was shown in Figure 1, and this effect was in a dose dependent manner.Figure. The binding activity of TP53 with CREBBP.)
Tumor Protein p53, Active Protein (Cat# AAA150105)
Full Name
Active Tumor Protein p53 (P53)
Gene Names
Tp53; p53; Trp53
Applications
Activity Assay, Cell Culture
Purity
>97%
Pricing
Bioactivity
(Figure 1. The binding activity of FABP4 with ACTb)
Fatty Acid Binding Protein 4, Active Protein (Cat# AAA150114)
Full Name
Active Fatty Acid Binding Protein 4 (FABP4)
Gene Names
FABP4; aP2; ALBP; AFABP; A-FABP; HEL-S-104
Applications
Activity Assay, Cell Culture
Purity
>90%
Pricing
Application Data
(Figure. Inhibition of 3T3 cell proliferation after stimulated with GREM1.)
Gremlin 1, Active Protein (Cat# AAA150126)
Full Name
Active Gremlin 1 (GREM1)
Gene Names
GREM1; DRM; HMPS; MPSH; PIG2; CRAC1; CRCS4; DAND2; HMPS1; IHG-2; DUP15q; C15DUPq; GREMLIN; CKTSF1B1
Applications
Activity Assay, Cell Culture
Purity
>97%
Pricing
Bioactivity
(The cytochrome P450 enzyme CYP2E1 catalyzes the oxidative metabolism of many solvents and other small organic molecules. CYP2E1 is expressed in adult and fetal human liver in addition to extrahepatic tissues such as lung and placenta. Treatment of primary cultures of human hepatocytes with ethanol induces CYP2E1 protein, and this is consistent with the finding that hepatic CYP2E1 protein and mRNA levels are increased in individuals with alcoholism. Although only a few drugs (e.g., acetaminophen have been identified as substrates for CYP2E1, many low molecular weight procarcinogens are activated by this cytochrome P450 (P450). Chlorzoxazone 6-hydroxylation, N-nitrosodimethylamine N-demethylation and p-nitrophenol hydroxylation can be used to measure the catalytic activity of CYP2E1. Thus, the recombinant human CYP2E1 activity was measured by its ability to hydroxylate p-nitrophenol to p-nitrocatechol. The reaction was performed in 50 mM potassium phosphate, pH 7.4 (Assay Buffer), initiated by addition 20 uL of 500 ug/ml CYP2E1 to 10 uL of 5 mM substrate p-nitrophenol and 30 ul of 26 mM NADPH in a total volume of 500 ul. Incubated at 37 degree C for 30min, then read at a wavelength of 535 nm after acidification of the reaction mixture with trichloroacetic acid followed by neutralization using 2 M NaOH.)
Cytochrome P450 2E1 (CYP2E1), Active Protein (Cat# AAA161816)
Full Name
Active Cytochrome P450 2E1 (CYP2E1)
Gene Names
CYP2E1; CPE1; CYP2E; P450-J; P450C2E
Applications
Activity Assay, Cell Culture
Purity
Greater than 90% by SDS-PAGE
Pricing
SDS-PAGE
(3 ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.)
Beta-lactaminase, Active Protein (Cat# AAA48963)
Full Name
Beta-lactaminase, E Coli, 20-377, His-tag, E Coli (Bioactivity Validated)
Gene Names
ampC; ampA; ECK4146; JW4111
Applications
Enzyme Activity, SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
Bioactivity
(MERS-CoV Spike RBD is coated at 2 ug/ml (100 ul/well) can bind human DPPIV/CD26 in a functional ELISA assay.)
MERS-CoV Spike, Active Protein (Cat# AAA48981)
Full Name
Recombinant MERS-CoV Spike RBD protein
Applications
Bioactivity, SDS-PAGE
Purity
> 90% by SDS-PAGE
Pricing
MERS-CoV Spike, Active Protein (Cat# AAA48982)
Full Name
Recombinant MERS-CoV Spike protein
Applications
Bioactivity, SDS-PAGE
Purity
> 85% by SDS-PAGE
Pricing
ICAM-1/CD54, Active Protein (Cat# AAA48983)
Full Name
Recombinant human ICAM-1/CD54 protein
Gene Names
ICAM1; BB2; CD54; P3.58
Applications
Bioactivity, SDS-PAGE
Purity
> 90% by SDS-PAGE
Pricing
Fc gamma RIIA/CD32a (R167H), Active Protein (Cat# AAA48984)
Full Name
Recombinant human Fc gamma RIIA/CD32a (R167H) protein
Gene Names
FCGR2A; CD32; FCG2; FcGR; CD32A; CDw32; FCGR2; IGFR2; FCGR2A1
Applications
Bioactivity, SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
EphA3, Active Protein (Cat# AAA48999)
Full Name
Recombinant mouse EphA3 protein
Gene Names
Epha3; Hek; Cek4; ETK1; End3; Hek4; Mek4; Tyro4; AW492086
Applications
Bioactivity, SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
Osteocrin, Active Protein (Cat# AAA49001)
Full Name
Recombinant Human Osteocrin protein
Gene Names
OSTN; MUSCLIN
Applications
Bioactivity, SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
SDS-PAGE
NME2, Active Protein (Cat# AAA48916)
Full Name
NME2, 1-152aa, Human, E Coli (Bioactivity Validated)
Gene Names
NME2; PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2
Applications
Enzyme Activity, SDS-PAGE
Purity
> 90% by SDS-PAGE
Pricing
IGF1, Active Protein (Cat# AAA75399)
Full Name
IGF1 protein
Gene Names
IGF1; IGFI; IGF-I; IGF1A
Purity
> 98% pure
Pricing
Insulin, Active Protein (Cat# AAA75245)
Full Name
Insulin protein
Gene Names
INS; IDDM; ILPR; IRDN; IDDM1; IDDM2; MODY10
Purity
> 99% pure
Pricing
BCA1, Active Protein (Cat# AAA75198)
Full Name
BCA1 protein
Gene Names
CA1; ARABIDOPSIS THALIANA SALICYLIC ACID-BINDING PROTEIN 3; ATBCA1; ATSABP3; BETA CARBONIC ANHYDRASE 1; CA1; carbonic anhydrase 1; F4P13.5; F4P13_5; SABP3; SALICYLIC ACID-BINDING PROTEIN 3
Purity
> 98% pure
Pricing
SDS-PAGE
(3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain)
Cyclophilin A, Active Protein (Cat# AAA48477)
Full Name
Cyclophilin A, 1-165aa, Human, E Coli (Bioactivity Validated)
Gene Names
PPIA; CYPA; CYPH; HEL-S-69p
Applications
Enzyme Activity, SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
SDS-PAGE
G6PD, Active Protein (Cat# AAA48520)
Full Name
G6PD,1-491aa, E Coli, E Coli (Bioactivity Validated)
Gene Names
zwf; ECK1853; JW1841
Applications
SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
SDS-PAGE
(3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.)
Carbonic anhydrase 2, Active Protein (Cat# AAA48538)
Full Name
Carbonic anhydrase 2, 1-260aa, Human, E Coli (Bioactivity Validated)
Gene Names
CA2; CAC; CAII; Car2; CA-II; HEL-76; HEL-S-282
Applications
Enzyme Activity, SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
Application Data
(Biological Acitivity: Human IL-6 stimulates cell proliferation of the TF-1 human erythroleukemic cells. The ED50 range )
Interleukin 6, Active Protein (Cat# AAA48546)
Full Name
Interleukin 6, 30-212aa, Human, His tag, E Coli (Bioactivity Validated)
Gene Names
IL6; CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2
Applications
Bioactivity, SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
Bioactivity
(Human CD47 is coated at 1 ug/ml (100 ul/well) can bind Human SIRP gamma/CD172g (CAT# ATGP4030) in a Functional ELISA assay.)
CD47, Active Protein (Cat# AAA48392)
Full Name
Recombinant human CD47 protein
Gene Names
CD47; IAP; OA3; MER6
Applications
Bioactivity, SDS-PAGE
Purity
>95% by SDS-PAGE
Pricing
Bioactivity
(Mouse IL-21 stimulates IFN-g secretion of the NK-92 human natural killer cells. The ED50 range )
IL-21, Active Protein (Cat# AAA48409)
Full Name
Recombinant Mouse IL-21 Protein
Gene Names
Il21; IL-21
Applications
Bioactivity, SDS-PAGE
Purity
>90% by SDS-PAGE
Pricing
Bioactivity
(Human IL-6 R alpha inhibits Human IL-6 induced cell proliferation in the M1 mouse myeloid leukemia cells. The ED50 range 20 ng/ml.)
IL-6R alpha, Active Protein (Cat# AAA48327)
Full Name
Recombinant IL-6R alpha
Gene Names
IL6R; IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1
Applications
Bioactivity, SDS-PAGE
Purity
> 90% by SDS - PAGE
Pricing
Bioactivity
(Canine IL-1B stimulates cell proliferation of the D10.G4.1 mouse helper T cells. The ED50 range range )
IL-1 beta/IL-1F2, Active Protein (Cat# AAA48366)
Full Name
Recombinant canine IL-1 beta/IL-1F2 protein
Gene Names
IL1B; IL-1
Applications
Bioactivity, SDS-PAGE
Purity
>95% by SDS-PAGE
Pricing
SDS-PAGE
SurA, Active Protein (Cat# AAA48603)
Full Name
SurA, 21-428aa, E Coli, His tag, E Coli (Bioactivity Validated)
Gene Names
surA; ECK0054; JW0052
Applications
SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
SDS-PAGE
(3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain)
LDHB, Active Protein (Cat# AAA48607)
Full Name
LDHB, 1-334aa, Human, His tag, E Coli (Bioactivity Validated)
Gene Names
LDHB; LDH-B; LDH-H; LDHBD; TRG-5; HEL-S-281
Applications
Enzyme Activity, SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
Hepatocyte Growth Factor, Active Protein (Cat# AAA38133)
Full Name
Recombinant Human Hepatocyte Growth Factor, CHO
Gene Names
HGF; SF; HGFB; HPTA; F-TCF; DFNB39
Purity
Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Pricing
Vascular Endothelial Growth Factor, Active Protein (Cat# AAA38137)
Full Name
Recombinant Human Vascular Endothelial Growth Factor, CHO
Gene Names
VEGFA; VPF; VEGF; MVCD1
Purity
Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Pricing
Insulin Like Growth Factor Binding Protein-3, Active Protein (Cat# AAA38150)
Full Name
Recombinant Human Insulin Like Growth Factor Binding Protein-3
Gene Names
IGFBP3; IBP3; BP-53
Purity
Greater than 97.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Pricing
Growth and Differentiation factor 15, Active Protein (Cat# AAA38164)
Full Name
Recombinant Human Growth and Differentiation factor 15
Gene Names
GDF15; PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15
Purity
Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Pricing
Leptin, Active Protein (Cat# AAA38172)
Full Name
Recombinant Mouse Leptin
Gene Names
Lep; ob; obese
Purity
Greater than 95.0% as determined by: (a) Analysis by SEC-HPLC. (b) Analysis by SDS-PAGE.
Pricing
Growth and Differentiation factor 5, Active Protein (Cat# AAA38207)
Full Name
Recombinant Human Growth and Differentiation factor 5
Gene Names
GDF5; OS5; LAP4; BDA1C; BMP14; CDMP1; LAP-4; SYM1B; SYNS2; BMP-14
Purity
Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Pricing
Mitogen-Activated Protein Kinase 1, Active Protein (Cat# AAA38388)
Full Name
Recombinant Human Mitogen-Activated Protein Kinase 1, Active
Gene Names
MAPK1; ERK; p38; p40; p41; ERK2; ERT1; ERK-2; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; p42-MAPK
Purity
The purity is greater than 95%.
Pricing
Vascular Endothelial Growth Factor receptor-1, Active Protein (Cat# AAA38398)
Full Name
Recombinant Human Vascular Endothelial Growth Factor receptor-1
Gene Names
FLT1; FLT; FLT-1; VEGFR1; VEGFR-1
Purity
Greater than 90.0% as determined by(a)Analysis by RP-HPLC. (b)Analysis by SDS-PAGE.
Pricing
KBP-Type Peptidyl-Prolyl Cis-Trans Isomerase, Active Protein (Cat# AAA38285)
Full Name
Recombinant E Coli KBP-Type Peptidyl-Prolyl Cis-Trans Isomerase
Gene Names
slyD; ECK3336; JW3311
Purity
Greater than 95.0% as determined by SDS-PAGE.
Pricing
Follicle Stimulating Hormone, Active Protein (Cat# AAA38350)
Full Name
Recombinant Human Follicle Stimulating Hormone
Purity
Greater than 95.0% as determined by SDS-PAGE.
Pricing
Lactate Dehydrogenase 2, Active Protein (Cat# AAA44810)
Full Name
Lactate Dehydrogenase 2 (LDH-2), Human Erythrocytes
Pricing
Superoxide Dismutase-1, Active Protein (Cat# AAA38724)
Full Name
Recombinant Human Superoxide Dismutase-1
Gene Names
SOD1; ALS; SOD; ALS1; IPOA; hSod1; HEL-S-44; homodimer
Purity
Greater than 95.0% as determined by SDS-PAGE.
Pricing
IL-32 alpha, Active Protein (Cat# AAA38596)
Full Name
Recombinant Human IL-32 alpha
Gene Names
IL32; NK4; TAIF; TAIFa; TAIFb; TAIFc; TAIFd; IL-32beta; IL-32alpha; IL-32delta; IL-32gamma
Purity
Greater than 97.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Pricing
Glutathione S-Transferase, Active Protein (Cat# AAA38680)
Full Name
Recombinant Glutathione S-Transferase
Purity
Greater than 95% as determined by SDS-PAGE.
Pricing
Thioredoxin Reductase 1, Active Protein (Cat# AAA38824)
Full Name
Recombinant Human Thioredoxin Reductase 1
Gene Names
TXNRD1; TR; TR1; TXNR; TRXR1; GRIM-12
Purity
Greater than 90% as determined by SDS-PAGE.
Pricing
ANGPTL-7, Active Protein (Cat# AAA76054)
Full Name
ANGPTL-7
Gene Names
ANGPTL7; AngX; CDT6; dJ647M16.1
Purity
>98%
IL2RA (CD25), Active Protein (Cat# AAA76070)
Full Name
Human IL2RA Recombinant (CD25)
Purity
>97%, as determined by SDS-PAGE and HPLC
Pricing
CD32b (FcgR2b), Active Protein (Cat# AAA76086)
Full Name
Human CD32b Recombinant (FcgR2b)
Purity
>95%, as determined by SDS-PAGE and HPLC
Pricing
EGFL7, Active Protein (Cat# AAA76105)
Full Name
Human EGFL7 Recombinant
Purity
>90%, as determined by SDS-PAGE
Pricing
Application Data
(KRAS G12V (HLA-A*03:01) Tetramer SPRSPR image shows curve for KRAS G12V(HLA-A*03:01) and immobilized Antibody binding, with a calculated affinity constant of 42nM)
HLA-A*03:01 KRAS G12V, Active Protein (Cat# AAA76371)
Full Name
HLA-A*03:01 KRAS G12V peptide Tetramer
Purity
purity was determined to be >95% by nonreducing PAGE and HPLC
Pricing
Application Data
(Polarized membrane extensions mediate osteoclast fusion.(D, top) Immunoblot analysis of lysates of RAW264.7 macrophages stimulated with RANKL for the indicated times with antibodies to Ser473-phosphorylated (p) or total forms of Akt.)
Soluble RANK ligand, Active Protein (Cat# AAA76384)
Full Name
Mouse Soluble RANK ligand Recombinant
Gene Names
Tnfsf11; ODF; OPG; OPGL; RANKL; Ly109l; Trance
Purity
>95%, as determined by SDS-PAGE and HPLC
Pricing
Application Data
(Generation of conditional TAK1-deficient mice.Colony formation by BM cells from Map3k7)
Granulocyte Colony Stimulating Factor, Active Protein (Cat# AAA76390)
Full Name
Mouse Granulocyte Colony Stimulating Factor Recombinant
Gene Names
Csf3; Csfg; G-CSF; MGI-IG
Purity
>95%, as determined by SDS-PAGE and HPLC
Pricing
Application Data
(Expression of programmed death-1 (PD-1) in macrophages/microglia after spinal cord injury (SCI) in mice.Immunohistochemistry in macrophages/microglia 14 days postinjury (dpi) in wild-type mice for (c) PD-1, (d) it’s ligand, PD-L1, and (e) PD-1 in M1 cells [inducible nitric oxide synthase (iNOS)+]; (f) PD-1 in M2 cells [arginase 1 (Arg1+)]; (g) PD-L1 in M1 cells (iNOS+); and (h) PD-L1 in M2 cells (Arg1+).)
PD-L1 (B7-H1), Active Protein (Cat# AAA76402)
Full Name
Human PD-L1 (B7-H1) Recombinant
Gene Names
Cd274; B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik
Purity
>95%, as determined by SDS-PAGE and HPLC
Pricing
What Are Active Proteins?
Proteins are large molecules made up of long chains of amino acids. They will typically fold into a very particular 3-dimensional shape/conformation, that is sometimes referred to as their “native” form, which allows them to work properly in the body. For the purposes of product categorization, AAA Biotech will typically refer to proteins purified from their original animal host as being “native” proteins (this is to signify their difference compared to their recombinant proteins or “synthetic” protein counterparts).
If a protein successfully folds into the correct shape, it will typically display high fidelity characteristics to its original protein in its original animal host and be classified as an active protein, as it will be able to function “normally” in most enzymatic or binding capacities. If it loses this shape, due to factors such as heat or strong chemicals (such as detergents), it becomes inactive and is no longer able to perform its basic functions.
All of the proteins in this category are made under strict quality control, and they are active, pure, low in contaminants, and stable. Most are stored as freeze-dried powders and come without extra tags, so they’re very close to the actual natural/native form.
Learn more in our guide “How active proteins work”.
Key Applications of Active Proteins
1. Scientific Research
- Aid in the study of how proteins function in the body
- Aid in understanding various disease processes
2. Drug Development
- Powerful tools to investigate how potential drugs interact with specific proteins
- Ideal for identifying drug targets
3. Cell Culture
- Are routinely utilized to support cell growth and function (e.g., using exogenous growth factors)
- Can be used to promote cellular development into specific types (differentiation)
4. Diagnostics
- Regularly utilized in tests to detect diseases or infections (e.g., COVID-19, cancer)
- Note: All products are strictly for research-use only (RUO).
5. Therapeutics
- Some active proteins are used directly as treatments (e.g., insulin, enzymes)
- Note: All products are strictly for research-use only (RUO).
6. Vaccine Development
- Used to create or test vaccines by mimicking parts of viruses or bacteria
7. Biochemical Assays
- They can facilitate the characterization of enzyme activity, binding strength, or protein interactions in lab tests
Why Buy Active Proteins from AAA Biotech?
- High biological activity – Verified to perform as expected or indicated on datasheet
- Strict quality control – We are confident in our active proteins’ reliability and consistency
- High purity & low endotoxin – Ideal for applications involving sensitive or precious samples/components
- Freeze-dried for stability – Long shelf life and straightforward storage
- Mostly tag-free – Closer to natural/native protein form
FAQ
1. What are active proteins used for in research?
Active proteins are used primarily in the study of how proteins function, in characterizing/discovering drug interactions, supporting cell growth, running biochemical assays, and in development of diagnostics or therapeutics.
2. How are AAA Biotech's active proteins validated?
AAA Biotech’s active proteins are validated through strict quality control and functional assays to ensure they are properly folded and active. “Active”, though, can be an ambiguous term, so if a specific “activity” or “binding” capability of a protein is of crucial interest to you, please inquire with us prior to purchase, and we will provide further details on how the “Active” modifier was determined to be applicable.
3. Are these proteins tested for biological activity?
Yes, all active proteins from AAA Biotech are tested to confirm they have the expected biological activity before being offered for use. Though, said “biological activity” can be either “enzymatic”, “binding”, or both.