Active Proteins

AAA Biotech also known as AAA Bio or AAABio provides a variety of high-quality recombinant and natural/native proteins that are proven to work in a wide range of experiments. Explore our products to find the active protein that best fits your needs or experimental model.

Viewing 300-350 of 2583 product results

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ERYTHROPOIETIN ALPHA, Active Protein (Cat# AAA50528)

Full Name

RECOMBINANT HUMAN ERYTHROPOIETIN ALPHA

Gene Names

EPO; EP; MVCD2

Applications

Functional Assay

Purity

>98.0% by HPLC analysis and SDS-PAGE

Pricing

IFN GAMMA, Active Protein (Cat# AAA50533)

Full Name

RECOMBINANT HUMAN INTERFERON GAMMA

Gene Names

IFNG; IFG; IFI

Applications

Western Blot, Functional Assay

Purity

>98% by SDS PAGE and HPLC

Pricing

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Bioactivity (HTRF Assay for Recombinant YES1 activity. 1 uM TK substrate was incubated with different concentrations of YES1 protein in 10 ul reaction system containing 1×Enzymatic Buffer, 5 mM MgCl2, 1 mM DTT and 100 uM ATP for 1 hour. The 10 ul detection reagents containing anti-TK antibody (1:2) and SA-XL665 (1:100) diluted with 1× Detection Buffer were added and incubated with the reactions for 30 min. All the operations and reactions were performed at room temperature. HTRF assay was used for detection.)

YES1, Active Protein (Cat# AAA60336)

Full Name

Recombinant YES1 protein

Purity

>50%

Pricing

Fc gamma RIIB/CD32b, Active Protein (Cat# AAA49000)

Full Name

Recombinant human Fc gamma RIIB/CD32b protein

Gene Names

FCGR2B; CD32; FCG2; CD32B; FCGR2; IGFR2

Applications

Bioactivity, SDS-PAGE

Purity

> 95% by SDS-PAGE

Pricing

GFR alpha-1, Active Protein (Cat# AAA49003)

Full Name

Recombinant human GFR alpha-1 protein

Gene Names

GFRA1; GDNFR; RET1L; RETL1; TRNR1; GDNFRA; GFR-ALPHA-1

Applications

Bioactivity, SDS-PAGE

Purity

> 90% by SDS-PAGE

Pricing

Peroxiredoxin 6, Active Protein (Cat# AAA48548)

Full Name

Peroxiredoxin 6, 1-224aa, Human, His tag, E Coli (Bioactivity Validated)

Gene Names

PRDX6; PRX; p29; AOP2; 1-Cys; NSGPx; aiPLA2; HEL-S-128m

Applications

SDS-PAGE, Enzyme Activity

Purity

> 95% by SDS-PAGE

Pricing

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LIFR alpha, Active Protein (Cat# AAA48367)

Full Name

Recombinant Mouse LIFR alpha Protein

Applications

Bioactivity, SDS-PAGE

Purity

>90% by SDS-PAGE

Pricing

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Application Data (WNT3 Is a Functional Biomarker for Predicting the DE Differentiation Potential (A) WNT3 levels in control and various knockdown HUES8 sublines correlate with their DE differentiation efficiency.The four protocols included the following treatments in a serum-free medium: (1) A - > A (Activin A only for 4 days); (2) AW - > A (Activin A and Wnt3a for 2 days followed by Activin A only for another 2 days); (3) A - > AX (Activin A only for 2 days followed by Activin A and XAV 939 for another 2 days); and (4) AW - > AX (Activin A and Wnt3a for 2 days followed by Activin A and XAV 939 for another 2 days).)

Activin, Active Protein (Cat# AAA76389)

Full Name

Human Activin Recombinant (CHO Cell)

Gene Names

INHBA; EDF; FRP

Purity

>97%, as determined by SDS-PAGE and HPLC

Pricing

Arginine Deiminase (ADI), Active Protein (Cat# AAA79254)

Full Name

Mycoplasma Arginine Deiminase (ADI)

Purity

> 98% by SDS-PAGE & HPLC analysis

Pricing

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Application Data (Fig. 3: Confluent PAE/KDR cells were stimulated with 50ng/ml human VEGF165 for 10 min at 37°C. Cells were lysed and an IP was performed using a mouse anti-human KDR antibody (Cat# WB was performed with a mouse anti-human KDR antibody (Cat# and an anti- Phosphotyrosine antibody.)

VEGF165, Active Protein (Cat# AAA79288)

Full Name

Human VEGF165

Gene Names

VEGFA; VPF; VEGF; MVCD1

Reactivity

Human

Purity

> 95% by SDS-PAGE & silver stain

Pricing

alpha-Glucosidase, Active Protein (Cat# AAA78980)

Full Name

alpha-Glucosidase, recombinant

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Bioactivity (Multimerin 1 (MMRN1) is a secreted glycoprotein that consists of multiple subunits, forming a complex with a molecular weight of approximately 150 kDa. MMRN1 is a member of the multimerin family and it is mainly expressed in platelets and endothelial cells. MMRN1 plays an important role in maintaining vascular integrity, regulating clotting and inflammatory responses, among others. In addition, the binding of MMRN1 to Vitronectin (VTN) plays an important role in a variety of physiological and pathological processes, including cell adhesion, migration, blood coagulation, and cell signaling. Thus a functional binding ELISA assay was conducted to detect the interaction of recombinant human MMRN1 and recombinant human VTN. Briefly, MMRN1 was diluted serially in PBS with 0.01% BSA (pH 7.4). Duplicate samples of 100 ul were then transferred to VTN-coated microtiter wells and incubated for 1h at 37 degree C. Wells were washed with PBST and incubated for 1h with anti-MMRN1 pAb, then aspirated and washed 3 times. After incubation with HRP labelled secondary antibody for 1h at 37 degree C, wells were aspirated and washed 5 times. With the addition of substrate solution, wells were incubated 15-25 minutes at 37 degree C. Finally, add 50 uL stop solution to the wells and read at 450/630 nm immediately. The binding activity of recombinant human MMRN1 and recombinant human VTN was shown in Figure 1, and this effect was in a dose dependent manner.)

Multimerin 1 (MMRN1), Active Protein (Cat# AAA161892)

Full Name

Active Multimerin 1 (MMRN1)

Gene Names

MMRN1; ECM; MMRN; GPIa*; EMILIN4

Applications

Activity Assay, Cell Culture

Purity

Greater than 95% by SDS-PAGE

Pricing

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Bioactivity (Figure 2. Cell proliferation of M-NFS-60 cells after stimulated with G-CSF.)

Bioactivity (G-CSF is a pleiotropic cytokine best known for its specific effects on the proliferation, differentiation, and activation of hematopoietic cells of the neutrophilic granulocyte lineage. It is produced mainly by monocytes and macrophages upon activation by endotoxin, TNF-alpha and IFN-gamma. In addition, various carcinoma cell lines and myeloblastic leukemia cells can express G-CSF constitutively. In vitro, G-CSF stimulates growth, differentiation and functions of cells from the neutrophil lineage. Consistent with its in vitro functions, G-CSF has been found to play important roles in defense against infection, in inflammation and repair, and in the maintenance of steady state hematopoiesis. The activity of G-CSF is usually measured by a cell proliferation assay using M-NFS60 mouse myelogenous leukemia lymphoblast cells. M-NFS60 cells were seeded into triplicate wells of 96-well plates at a density of 8,000 cells/well with 2% serum standard 1640 which contains various concentrations of recombinant pig G-CSF. After incubated for 3 days, cells were observed by inverted microscope and cell proliferation was measured by Cell Counting Kit-8 (CCK-8). Briefly, 10 ul of CCK-8 solution was added to each well of the plate, then the absorbance at 450 nm was measured using a microplate reader after incubating the plate for 2-4 hours at 37 degree C. Proliferation of M-NFS-60 cells after incubation with G-CSF for 3 days observed by inverted microscope was shown in Figure 1. Cell viability was assessed by CCK-8 (Cell Counting Kit-8) assay after incubation with recombinant pig G-CSF for 3 days. The result was shown in Figure 2. It was obvious that G-CSF significantly increased cell viability of M-NFS-60 cells. The EC50 is 0.3 ng/ml)

Colony Stimulating Factor 3, Granulocyte (GCSF), Active Protein (Cat# AAA161665)

Full Name

Active Colony Stimulating Factor 3, Granulocyte (GCSF)

Gene Names

CSF3; G-CSF

Applications

Activity Assay, Cell Culture

Purity

Greater than 80% by SDS-PAGE

Pricing

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Bioactivity (Figure. The binding activity of FGF23 with FGFR2.Fibroblast growth factor 23 or FGF23 is a member of the fibroblast growth factor (FGF) family which is responsible for phosphate and vitamin D metabolism. The main function of FGF23 seems to be regulation of phosphate concentration in plasma. FGF23 decreases the reabsorption and increases excretion of phosphate and suppress 1-alpha-hydroxylase, reducing its ability to activate vitamin D and subsequently impairing calcium absorption. Besides, Fibroblast Growth Factor Receptor 2 (FGFR2) has been identified as an interactor of FGF23, thus a binding ELISA assay was conducted to detect the interaction of recombinant human FGF23 and recombinant human FGFR2. Briefly, FGF23 were diluted serially in PBS, with 0.01% BSA (pH 7.4). Duplicate samples of 100uL were then transferred to FGFR2-coated microtiter wells and incubated for 2h at 37. Wells were washed with PBST and incubated for 1h with anti-FGF23 pAb, then aspirated and washed 3 times. After incubation with HRP labelled secondary antibody, wells were aspirated and washed 3 times. With the addition of substrate solution, wells were incubated 15-25 minutes at 37. Finally, add 50uL stop solution to the wells and read at 450nm immediately. The binding activity of FGF23 and FGFR2 was shown in Figure 1, and this effect was in a dose dependent manner.)

Fibroblast Growth Factor 23, Active Protein (Cat# AAA150099)

Full Name

Active Fibroblast Growth Factor 23 (FGF23)

Gene Names

FGF23; ADHR; FGFN; HYPF; HFTC2; HPDR2; PHPTC

Applications

Activity Assay, Cell Culture

Purity

>95%

Pricing

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WB (Western Blot) (Sample: Recombinant Lpa, Human;Antibody: Rabbit Anti-Human Lpa Ab)

Lipoprotein, a, Active Protein (Cat# AAA150102)

Full Name

Active Lipoprotein, a (Lpa)

Gene Names

LPA; LP; AK38; APOA

Reactivity

Homo sapiens (Human)

Applications

Activity Assay, Cell Culture

Purity

>90%

Pricing

BAFF R/TNFRSF13C, Active Protein (Cat# AAA48988)

Full Name

Recombinant human BAFF R/TNFRSF13C protein

Gene Names

TNFRSF13C; BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin

Applications

Bioactivity, SDS-PAGE

Purity

> 95% by SDS-PAGE

Pricing

GSTM1, Active Protein (Cat# AAA48521)

Full Name

GSTM1, 1-218aa, Mouse, E Coli (Bioactivity Validated)

Gene Names

Gstm1; Gstb1; Gstb-1

Applications

SDS-PAGE

Purity

> 95% by SDS-PAGE

Pricing

Cancer Antigen 19-9, Active Protein (Cat# AAA44842)

Full Name

Cancer Antigen 19-9 (CA 19-9), Human

Purity

Highly Purified

Pricing

Pepsinogen II, Active Protein (Cat# AAA44860)

Full Name

Pepsinogen II (PGII/PGC), Human Gastric Mucosa

Gene Names

PGC; PEPC; PGII

Applications

Western Blot

Purity

>90% (SDS-PAGE) may contain minor cleavage products.

Full Name

Recombinant Human Protein Disulfide Isomerase A6, Active

Gene Names

PDIA6; P5; ERP5; TXNDC7

Purity

Greater than 90.0% as determined by SDS-PAGE.

Pricing

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Full Name

FITC Labeled Bovine Fibrinogen

Purity

>95% by SDS-PAGE analysis

Pricing

Glutathione S-Transferase Alpha 1, Active Protein (Cat# AAA38702)

Full Name

Recombinant Human Glutathione S-Transferase Alpha 1

Gene Names

GSTA1; GST2; GTH1; GSTA1-1

Purity

Greater than 90.0% as determined by SDS-PAGE.

Full Name

Recombinant Carp Growth Hormone

Purity

Greater than 95.0% as determined by: (a) Analysis by SEC-HPLC. (b) Analysis by SDS-PAGE.

Pricing

Interferon-gamma, Active Protein (Cat# AAA38173)

Full Name

Recombinant Mouse Interferon-gamma

Gene Names

Ifng; Ifg; IFN-g

Purity

Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Pricing

Transforming Growth Factor-Beta 3, Active Protein (Cat# AAA38178)

Full Name

Recombinant Human Transforming Growth Factor-Beta 3

Gene Names

TGFB3; ARVD; RNHF; ARVD1; TGF-beta3

Purity

Greater than 96.0% as determined by SDS-PAGE.

Pricing

Interleukin-3, Active Protein (Cat# AAA38180)

Full Name

Recombinant Mouse Interleukin-3

Gene Names

Il3; BPA; PSF; HCGF; Il-3; MCGF; Csfmu

Purity

Greater than 97.0% as determined by: (a) Analysis by SEC-HPLC. (b) Analysis by SDS-PAGE.

Pricing

Tumor Necrosis Factor Receptor 2 Fusion Protein, Active Protein (Cat# AAA38200)

Full Name

Recombinant Human Tumor Necrosis Factor Receptor 2 Fusion Protein

Gene Names

TNFRSF1B; p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II

Purity

Greater than 98.0% as determined by: (a) Analysis by RP-HPLC.(c) Analysis by SDS-PAGE.

Pricing

Disulfide Isomerase, Active Protein (Cat# AAA38241)

Full Name

Recombinant Human Protein Disulfide Isomerase

Gene Names

P4HB; DSI; GIT; PDI; PHDB; PDIA1; PO4DB; PO4HB; PROHB; ERBA2L; P4Hbeta

Purity

Greater than 95.0% as determined by a) Analysis by RP-HPLC. b) Analysis by SDS-PAGE.

Pricing

Insulin Like Growth Factor-1 Des, Active Protein (Cat# AAA38547)

Full Name

Recombinant Human Insulin Like Growth Factor-1 Des (1-3)

Gene Names

IGF1; IGFI; IGF-I; IGF1A

Purity

Greater than 97.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.

Pricing

ACE2, Active Protein (Cat# AAA78494)

Full Name

Human ACE2 Protein (Fc Tag)

Purity

>=90% (SDS-PAGE)

Pricing

What Are Active Proteins?

Proteins are large molecules made up of long chains of amino acids.
They will typically fold into a very particular 3-dimensional shape/conformation, that is sometimes referred to as their “native” form, which allows them to work properly in the body. For the purposes of product categorization, AAA Biotech will typically refer to proteins purified from their original animal host as being “native” proteins (this is to signify their difference compared to their “recombinant” or “synthetic” protein counterparts).

If a protein successfully folds into the correct shape, it is will typically display high fidelity characteristics to its original protein in its original animal host, and be classified as an active protein, as it will be able to function “normally” in most enzymatic or binding capacities. If it loses this shape, due to factors such as heat or strong chemicals (such as detergents), it becomes inactive and is no longer able to perform its basic functions. All of the proteins in this category are made under strict quality control, and they are active, pure, low in contaminants, and stable.
Most are stored as freeze-dried powders and come without extra tags, so they’re very close to the actual natural/native form.

Key Applications of Active Proteins

1. Scientific Research

Aid in the study of how proteins function in the body

Aid in understanding various disease processes

2. Drug Development

Powerful tools to investigate how potential drugs interact with specific proteins

Ideal for identifying drug targets

3. Cell Culture

Are routinely utilized to support cell growth and function (e.g., using exogenous growth factors)

Can be used to promote cellular development into specific types (differentiation)

4. Diagnostics

Regularly utilized in tests to detect diseases or infections (e.g., COVID-19, cancer)

Note: All products are strictly for research-use only (RUO).

5. Therapeutics

Some active proteins are used directly as treatments (e.g., insulin, enzymes)

Note: All products are strictly for research-use only (RUO).

6. Vaccine Development

Used to create or test vaccines by mimicking parts of viruses or bacteria

7. Biochemical Assays

They can facilitate the characterization of enzyme activity, binding strength, or protein interactions in lab tests

Why Buy Active Proteins from AAA Biotech?

High biological activity – Verified to perform as expected or indicated on datasheet

Strict quality control – We are confident in our active proteins’ reliability and consistency

High purity & low endotoxin – Ideal for applications involving sensitive or precious samples/components

Freeze-dried for stability – Long shelf life and straightforward storage

Mostly tag-free – Closer to natural/native protein form

FAQ

1. What are active proteins used for in research?

Active proteins are used primarily in the study of how proteins function, in characterizing/discovering drug interactions, supporting cell growth, running biochemical assays, and in development of diagnostics or therapeutics.

2. How are AAA Biotech's active proteins validated?

AAA Biotech’s active proteins are validated through strict quality control and functional assays to ensure they are properly folded and active. “Active”, though, can be an ambiguous term, so if a specific “activity” or “binding” capability of a protein is of crucial interest to you, please inquire with us prior to purchase, and we will provide further details on how the “Active” modifier was determined to be applicable.

3. Are these proteins tested for biological activity?

Yes, all active proteins from AAA Biotech are tested to confirm they have the expected biological activity before being offered for use. Though, said “biological activity” can be either “enzymatic”, “binding”, or both.

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Active Proteins

Viewing 300-350 of 2583 product results

ERYTHROPOIETIN ALPHA, Active Protein (Cat# AAA50528)

IFN GAMMA, Active Protein (Cat# AAA50533)

YES1, Active Protein (Cat# AAA60336)

Fc gamma RIIB/CD32b, Active Protein (Cat# AAA49000)

GFR alpha-1, Active Protein (Cat# AAA49003)

Peroxiredoxin 6, Active Protein (Cat# AAA48548)

LIFR alpha, Active Protein (Cat# AAA48367)

Activin, Active Protein (Cat# AAA76389)

Arginine Deiminase (ADI), Active Protein (Cat# AAA79254)

VEGF165, Active Protein (Cat# AAA79288)

alpha-Glucosidase, Active Protein (Cat# AAA78980)

Multimerin 1 (MMRN1), Active Protein (Cat# AAA161892)

Colony Stimulating Factor 3, Granulocyte (GCSF), Active Protein (Cat# AAA161665)

Fibroblast Growth Factor 23, Active Protein (Cat# AAA150099)

Lipoprotein, a, Active Protein (Cat# AAA150102)

BAFF R/TNFRSF13C, Active Protein (Cat# AAA48988)

GSTM1, Active Protein (Cat# AAA48521)

Cancer Antigen 19-9, Active Protein (Cat# AAA44842)

Pepsinogen II, Active Protein (Cat# AAA44860)

beta-Human Chorionic Gonadotrophin, Active Protein (Cat# AAA44799)

Keratinocyte Growth Factor-2, Active Protein (Cat# AAA38945)

Pegylated Granulocyte-Colony, Active Protein (Cat# AAA38985)

Matrix Metalloproteinase-1, Active Protein (Cat# AAA39015)

Disulfide Isomerase A6, Active Protein (Cat# AAA39147)

COVID 19 Spike S1 Protein Coronavirus, Active Protein (Cat# AAA41021)

Malate Dehydrogenase 2, Active Protein (Cat# AAA38044)

Granzyme-B, Active Protein (Cat# AAA38045)

I-309, Active Protein (Cat# AAA38084)

Growth Hormone, Active Protein (Cat# AAA38106)

Brain-Derived Neurotrophic Factor, Active Protein (Cat# AAA38107)

FITC Labeled Bovine Fibrinogen, Active Protein (Cat# AAA37784)

Glutathione S-Transferase Alpha 1, Active Protein (Cat# AAA38702)

Trypsin, Active Protein (Cat# AAA38727)

Acid Phosphatase-1, Active Protein (Cat# AAA38771)

Tyrosine Phosphatase Non Receptor Type-1, Active Protein (Cat# AAA38391)

Fibroblast Growth Factor Receptor-2, Active Protein (Cat# AAA38396)

Vascular Endothelial Growth Factor receptor-2 Fc Chimera, Active Protein (Cat# AAA38400)

Coagulation Factor VIII, Active Protein (Cat# AAA38430)

Keratinocyte Growth Factor, Active Protein (Cat# AAA38113)

Granulocyte Macrophage-Colony Stimulating Factor, Active Protein (Cat# AAA38115)

Platelet Derived Growth Factor-BB, Active Protein (Cat# AAA38129)

Interleukin-1 beta, Active Protein (Cat# AAA38142)

Carp Growth Hormone, Active Protein (Cat# AAA38148)

Interferon-gamma, Active Protein (Cat# AAA38173)

Transforming Growth Factor-Beta 3, Active Protein (Cat# AAA38178)

Interleukin-3, Active Protein (Cat# AAA38180)

Tumor Necrosis Factor Receptor 2 Fusion Protein, Active Protein (Cat# AAA38200)

Disulfide Isomerase, Active Protein (Cat# AAA38241)

Insulin Like Growth Factor-1 Des, Active Protein (Cat# AAA38547)

ACE2, Active Protein (Cat# AAA78494)

What Are Active Proteins?

Key Applications of Active Proteins

1. Scientific Research

2. Drug Development

3. Cell Culture

4. Diagnostics

5. Therapeutics

6. Vaccine Development

7. Biochemical Assays

Why Buy Active Proteins from AAA Biotech?

FAQ

1. What are active proteins used for in research?

2. How are AAA Biotech's active proteins validated?

3. Are these proteins tested for biological activity?

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