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▼Active Proteins
AAA Biotech also known as AAA Bio or AAABio provides a variety of high-quality recombinant and natural/native proteins that are proven to work in a wide range of experiments. Explore our products to find the active protein that best fits your needs or experimental model.
Viewing 400-450 of 2875 product results
Bioactivity
Tnf, Active Protein (Cat# AAA119943)
Full Name
Recombinant Human Tnf protein
Gene Names
Tnf; DIF; Tnfa; TNF-a; TNFSF2; Tnlg1f; Tnfsf1a; TNFalpha; TNF-alpha
Purity
>90% as determined by SDS-PAGE
Pricing
SDS-PAGE
MMP-8, Active Protein (Cat# AAA257855)
Full Name
MMP-8 Protein, Human, Recombinant (His Tag)
Gene Names
MMP8; HNC; CLG1; MMP-8; PMNL-CL
Purity
>90% as determined by SDS-PAGE
Pricing
Granulocyte-Colony Stimulating Factor, Active Protein (Cat# AAA38160)
Full Name
Recombinant Human Granulocyte-Colony Stimulating Factor, CHO
Gene Names
CSF3; GCSF; CSF3OS; C17orf33
Purity
Greater than 97.0% as determined by: a) Analysis by RP-HPLC. b) Analysis by SDS-PAGE.
Pricing
Epidermal Growth Factor Receptor-Sf9, Active Protein (Cat# AAA38416)
Full Name
Recombinant Human Epidermal Growth Factor Receptor-Sf9 (ErbB1), Active
Gene Names
EGFR; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2
Pricing
Glu-C, Active Protein (Cat# AAA79131)
Full Name
Staphylococcus Glu-C
Reactivity
Staphylococcus
Purity
> 98% by SDS-PAGE & HPLC analysis
Pricing
RANKL, soluble, Active Protein (Cat# AAA79211)
Full Name
Rat RANKL, soluble
Gene Names
Tnfsf11; RANKL
Reactivity
Rat
Purity
> 98% by SDS-PAGE & HPLC analyses
Pricing
Application Data
SCF, Active Protein (Cat# AAA79243)
Full Name
Mouse SCF
Gene Names
Kitl; Gb; SF; Sl; Clo; Con; Mgf; SCF; SLF; blz; Kitlg; contrasted
Reactivity
Mouse
Purity
> 95% by SDS-PAGE & silver stain
Pricing
Application Data
(Fig. 2: Dose-dependent stimulation of cell proliferation in NFS60 cells by recombinant human M-CSF. Values are the means (±SD) of triplicate determinations and expressed as percentage of control.)
M-CSF, Active Protein (Cat# AAA79123)
Full Name
Human M-CSF
Gene Names
CSF1; MCSF; CSF-1
Reactivity
Human
Purity
> 95% by SDS-PAGE
Pricing
sDLL4, Active Protein (Cat# AAA75582)
Full Name
sDLL4 protein
Gene Names
DLL4; hdelta2
Purity
> 95% pure
Pricing
PAI2, Active Protein (Cat# AAA75570)
Full Name
PAI2 protein
Gene Names
SERPINB2; PAI; PAI2; PAI-2; PLANH2; HsT1201
Purity
> 95% pure
Pricing
Application Data
Leptin (LEP), Active Protein (Cat# AAA148160)
Full Name
Active Leptin (LEP)
Gene Names
LEP; OB; OBS; LEPD
Reactivity
Human
Applications
Activity Assay, Cell Culture
Purity
> 90%
Pricing
Application Data
Fibroblast Growth Factor 13 (FGF13), Active Protein (Cat# AAA148205)
Full Name
Active Fibroblast Growth Factor 13 (FGF13)
Gene Names
Fgf13; FGF-13
Reactivity
Rat
Applications
Activity Assay, Cell Culture
Purity
> 97%
Pricing
Application Data
(Measured by its ability to inhibit FGF acidic dependent proliferation of Balb/c3T3 mouse embryonic fibroblasts. The ED50 for this effect is typically 200-400 ng/mL.)
FGFR2, Active Protein (Cat# AAA257934)
Full Name
FGFR2 Protein, Human, Recombinant (His Tag)
Gene Names
FGFR2; BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM
Purity
>97% as determined by SDS-PAGE
Pricing
Application Data
(Immobilized ACE2 Protein, Human, Recombinant (mFc Tag) at 2 ug/mL (100 uL/well) can bind SARS-CoV-2 (2019-nCoV) Spike RBD (L452R, E484Q) Protein (His Tag), the EC50 of SARS-CoV-2 (2019-nCoV) Spike RBD (L452R, E484Q) Protein (His Tag) is 5.0-30.0 ng/mL.)
COVID 19 Spike RBD (L452R, E484Q) Protein (His Tag) Coronavirus, Active Protein (Cat# AAA258108)
Full Name
SARS-CoV-2 (2019-nCoV) Spike RBD (L452R, E484Q) Protein (His Tag)
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
(Measured by its binding ability in a functional ELISA. Immobilized human ErbB2 at 2.5 ug/ml can bind Herceptin with a linear range of 3.2-80 ng/ml.)
Her2/ERBB2, Active Protein (Cat# AAA257809)
Full Name
Her2/ERBB2 Protein, Human, Recombinant (ECD, hFc Tag)
Gene Names
ERBB2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu
Purity
>90% as determined by SDS-PAGE
Pricing
Application Data
Interleukin 16 (IL16), Active Protein (Cat# AAA148141)
Full Name
Active Interleukin 16 (IL16)
Gene Names
IL16; LCF; NIL16; PRIL16; prIL-16
Reactivity
Human
Applications
Activity Assay, Cell Culture
Purity
> 97%
Pricing
Bioactivity
(Interleukin 1 beta (IL-1beta) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and other names, is a member of the interleukin 1 family of cytokines. This cytokine is an important medi)
Interleukin 1 Beta (IL1b), Active Protein (Cat# AAA153044)
Full Name
Active Interleukin 1 Beta (IL1b)
Applications
Activity Assay, Cell Culture
Purity
Greater than 97% by SDS-PAGE
Pricing
Glutathione S-Transferase, Active Protein (Cat# AAA38680)
Full Name
Recombinant Glutathione S-Transferase
Purity
Greater than 95% as determined by SDS-PAGE.
Pricing
IFN-gamma, Active Protein (Cat# AAA79149)
Full Name
Mouse IFN-gamma
Gene Names
Ifng; Ifg; IFN-g
Reactivity
Mouse
Purity
> 98% by SDS-PAGE & HPLC analyses
Pricing
Syndecan-2 (SDC2), Active Protein (Cat# AAA235618)
Full Name
Recombinant Human Syndecan-2 (SDC2), Partial
Gene Names
SDC2; HSPG; CD362; HSPG1; SYND2
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Pricing
Application Data
(Measured by its binding ability in a functional ELISA. Immobilized Mouse VEGF164 at 2 ug/ml (100 ul/well) can bind Mouse Neuropilin-1 mFc, the EC50 of Mouse Neuropilin-1 mFc is 4.0-20.0 ng/mL.)
Neuropilin-1, Active Protein (Cat# AAA258170)
Full Name
Neuropilin-1 Protein, Mouse, Recombinant (ECD, mFc Tag)
Gene Names
Nrp1; Nrp; NP-1; Npn1; NPN-1; C530029I03
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
(Measured by its binding ability in a functional ELISA. Immobilized human ACE2 protein (Fc tag)(10108-H05H) at 2 ug/mL (100 uL/well) can bind SARS-CoV-2 (2019-nCoV) Spike RBD-His (V483A) Recombinant Protein (40592-V08H5), the EC50 of SARS-CoV-2 (2019-nCoV) Spike RBD-His (V483A) Recombinant Protein (40592-V08H5) is 20-50 ng/mL.)
COVID 19 Spike RBD-His (V483A) Coronavirus, Active Protein (Cat# AAA258097)
Full Name
SARS-CoV-2 (2019-nCoV) Spike RBD-His (V483A) Recombinant Protein
Purity
>95% as determined by SDS-PAGE
Pricing
HIV1 gp120, Active Protein (Cat# AAA75444)
Full Name
HIV1 gp120 protein
Purity
> 95% by SDS-PAGE
Pricing
C1 Inhibitor, Active Protein (Cat# AAA79182)
Full Name
Human CD14, soluble
Reactivity
Human
Purity
> 95% by SDS-PAGE gel and HPLC analysis.
Pricing
Neuregulin-1/Heregulin-b2, Active Protein (Cat# AAA38192)
Full Name
Recombinant Human Neuregulin-1/Heregulin-b2
Gene Names
NRG1; GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF; MST131; MSTP131; NRG1-IT2
Purity
Greater than 96.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Pricing
Vascular Endothelial Growth Factor C, Active Protein (Cat# AAA38552)
Full Name
Recombinant Human Vascular Endothelial Growth Factor C
Gene Names
VEGFC; VRP; Flt4-L; LMPH1D
Purity
Greater than 90.0% as determined by SDS-PAGE.
Pricing
Bioactivity
(Brain-derived neurotrophic factor, also known as BDNF, is a member of the neurotrophin family of growth factors, which are related to the canonical Nerve Growth Factor. BDNF acts on certain neurons of the central nervous system and the peripheral nervous system, helping to support the survival of existing neurons, and encourage the growth and differentiation of new neurons and synapses. Besides, Sortilin 1 (SORT1) has been identified as an interactor of BDNF, thus a binding ELISA assay was conducted to detect the interaction of recombinant human BDNF and recombinant human SORT1. Briefly, SORT1 were diluted serially in PBS with 0.01% BSA (pH 7.4). Duplicate samples of 100ul were then transferred to BDNF-coated microtiter wells and incubated for 2h at 37 degree C. Wells were washed with PBST and incubated for 1h with anti-SORT1 pAb, then aspirated and washed 3 times. After incubation with HRP labelled secondary antibody, wells were aspirated and washed 3 times. With the addition of substrate solution, wells were incubated 15-25 minutes at 37 degree C. Finally, add 50uL stop solution to the wells and read at 450/630nm immediately. The binding activity of of BDNF and SORT1 was shown in Figure 1, and this effect was in a dose dependent manner.)
Brain Derived Neurotrophic Factor (BDNF), Active Protein (Cat# AAA152273)
Full Name
Active Brain Derived Neurotrophic Factor (BDNF)
Gene Names
BDNF; ANON2; BULN2
Applications
Activity Assay, Cell Culture
Purity
Greater than 95% by SDS-PAGE
Pricing
Application Data
(Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is typically 0.5-2.5 ng/ml.)
Oncostatin M/OSM, Active Protein (Cat# AAA257885)
Full Name
Oncostatin M/OSM Protein, Human, Recombinant (His Tag)
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
(Measured by its ability to inhibit FGF acidic (aFGF / FGF1) dependent proliferation of Balb/c3T3 mouse embryonic fibroblasts. The ED50 for this effect is typically 0.1-0.6 ug/mL.)
FGFR4, Active Protein (Cat# AAA258142)
Full Name
FGFR4 Protein, Mouse, Recombinant (His & hFc Tag)
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
(Immobilized human ACE2 protein (Fc tag)(Cat: 10108-H05H) at 2 ug/mL (100 uL/well) can bind Recombinant SARS-CoV-2 BM.1.1.1 (Omicron) Spike RBD Protein (His Tag)(Cat:AAA258597), the EC50 is 20-60 ng/mL.)
COVID 19 BM.1.1.1 (Omicron) Spike RBD Coronavirus, Active Protein (Cat# AAA258597)
Full Name
SARS-CoV-2 BM.1.1.1 (Omicron) Spike RBD Protein (His Tag)
Purity
>95% as determined by SDS-PAGE. >95% as determined by SEC-HPLC.
Pricing
Application Data
(Measured by its binding ability in a functional ELISA. Immobilized Human ACE2 (mFc tag) at 2 ug/mL (100 uL/well) can bind SARS-CoV-2 (2019-nCoV) Spike RBD(F490L)-His, the EC50 of SARS-CoV-2 (2019-nCoV) Spike RBD(F490L)-His is 30-150ng/mL.)
COVID 19 Spike RBD(F490L)-His Coronavirus, Active Protein (Cat# AAA258104)
Full Name
SARS-CoV-2 (2019-nCoV) Spike RBD(F490L)-His Recombinant Protein
Purity
>95% as determined by SDS-PAGE
Pricing
GDNF, Active Protein (Cat# AAA79245)
Full Name
Mouse GDNF
Gene Names
Gdnf; AI385739
Reactivity
Mouse
Purity
> 98% by SDS-PAGE and HPLC analyses
Pricing
Enterokinase, Active Protein (Cat# AAA79292)
Full Name
Human Enterokinase
Gene Names
TMPRSS15; ENTK; PRSS7
Purity
>90% by SDS-PAGE & HPLC analyses
Pricing
WISP1, Active Protein (Cat# AAA75458)
Full Name
WISP1 protein
Gene Names
WISP1; CCN4; WISP1c; WISP1i; WISP1tc
Purity
> 98% pure
Pricing
Bioactivity
(Mouse SPP1 stimulates cell adhesion of the HEK293 human embryonic kidney cells. The ED50 range )
Osteopontin/OPN, Active Protein (Cat# AAA48410)
Full Name
Recombinant mouse Osteopontin/OPN protein
Applications
Bioactivity, SDS-PAGE
Purity
>90% by SDS-PAGE
Pricing
Bioactivity
(MMP1 is a zinc-dependent enzymes capable of cleaving components of the extracellular matrix, which belongs to the matrix metalloproteinase (MMP) family. MMP-1 (interstitial collagenase), can degrade a broad range of substrates including types I, II, III, VII, VIII, and X collagens as well as casein, gelatin and so on. MMP-1 is expressed by fibroblasts, keratinocytes, endothelial cells, monocytes and macrophages. Structurally, MMP-1 may be divided into several distinct domains; a pro-domain which is cleaved upon activation; a catalytic domain containing the zinc binding site; a short hinge region and a carboxyl terminal (hemopexin-like) domain. The activity of recombinant pig MMP1 is measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2 in the assay buffer 50 mM Tris, 10 mM CaCl2, 150 mM NaCl, 0.05% (w/v) Brij-35, pH 7.5. The rpMMP1 is diluted to 50 ug/ml in assay buffer, then activated by p-aminophenylmercuric acetate (APMA) in a final concentration of 1 mM incubated at 37 degree C for 2 hours. The activated rpMMP-1 is diluted to 1 ug/mL in assay buffer. Loading into a black well plate 50 uL of 1 ug/mL rpMMP-1 and start the reaction by adding 50 uL of 20 uM substrate, with a substrate blank containing 50 uL assay buffer, 50 uL substrate, and no rpMMP-1. Then read at excitiation and emission wavelengths of 320 nm and 405 nm, respectively, in kinetic mode for 5 minutes. The specific activity of recombinant pig MMP1 is > 10 pmol/min/ug.)
Matrix Metalloproteinase 1 (MMP1), Active Protein (Cat# AAA161686)
Full Name
Active Matrix Metalloproteinase 1 (MMP1)
Gene Names
MMP1; Mmp1a
Applications
Activity Assay, Cell Culture
Purity
Greater than 90% by SDS-PAGE
Pricing
Application Data
Macrophage Inflammatory Protein 1 Alpha (MIP1a), Active Protein (Cat# AAA146611)
Full Name
Active Macrophage Inflammatory Protein 1 Alpha (MIP1a)
Gene Names
CCL3; MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha
Applications
Activity Assay, Cell Culture
Purity
> 95%
Pricing
Application Data
Leptin (LEP), Active Protein (Cat# AAA214276)
Full Name
Recombinant Human Leptin (LEP)
Gene Names
LEP; OB; OBS; LEPD
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
MANF, Active Protein (Cat# AAA214286)
Full Name
Recombinant Human MANF
Gene Names
MANF; ARP; ARMET
Purity
>95% as determined by SDS-PAGE
Pricing
Bioactivity
(Figure 2. Cell apoptosis of A549 cells after stimulated with recombinant dog IFNb.)
Interferon Beta (IFNb), Active Protein (Cat# AAA153002)
Full Name
Active Interferon Beta (IFNb)
Applications
Activity Assay, Cell Culture
Purity
Greater than 90% by SDS-PAGE
Pricing
Interferon-beta 1b, Active Protein (Cat# AAA38124)
Full Name
Recombinant Human Interferon-beta 1b
Gene Names
IFNB1; IFB; IFF; IFNB
Purity
Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Pricing
FGF basic/FGF-2, Active Protein (Cat# AAA48985)
Full Name
Recombinant human FGF basic/FGF-2 protein
Gene Names
FGF2; BFGF; FGFB; FGF-2; HBGF-2
Applications
Bioactivity, SDS-PAGE
Purity
> 95% by SDS-PAGE
Pricing
RANK/TNFRSF11A, Active Protein (Cat# AAA49004)
Full Name
Recombinant mouse RANK/TNFRSF11A protein
Gene Names
Tnfrsf11a; OFE; ODFR; Rank; Ly109; mRANK; TRANCE-R
Applications
Bioactivity, SDS-PAGE
Purity
> 90% by SDS-PAGE
Pricing
Application Data
LIF, Active Protein (Cat# AAA79172)
Full Name
Mouse LIF
Reactivity
Mouse
Purity
> 98% by SDS-PAGE & silver stain
Pricing
Thioredoxin Reductase, Active Protein (Cat# AAA78972)
Full Name
Thioredoxin Reductase (yeast) (rNTR (yeast))
Purity
>95% as determined by SDS-PAGE stained with CBBR.
Pricing
CD32b (FcgR2b), Active Protein (Cat# AAA76086)
Full Name
Human CD32b Recombinant (FcgR2b)
Purity
>95%, as determined by SDS-PAGE and HPLC
Pricing
Neuritin, Active Protein (Cat# AAA75585)
Full Name
Neuritin protein
Gene Names
NRN1; NRN; dJ380B8.2
Purity
> 98% as determined by SDS-PAGE and HPLC
Pricing
MCP1, Active Protein (Cat# AAA75441)
Full Name
MCP1 protein
Purity
>98% by SDS-PAGE gel and HPLC analysis
Pricing
Bioactivity
(Retinol-binding protein 4 (RBP4) is the specific carrier for retinol (also known as vitamin A), and is responsible for the conversion of unstable and insoluble retinol in aqueous solution into stable and soluble complex in plasma through their tight interaction. As a member of the lipocalin superfamily, RBP4 containing a beta-barrel structure with a well-defined cavity is secreted from the liver, and in turn delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP4-retinol complex interacts with transthyretin (TTR), and this binding is crucial for preventing RBP4 excretion through the kidney glomeruli. RBP4 expressed from an ectopic source efficiently delivers retinol to the eyes, and its deficiency affects night vision largely. Recently, RBP4 as an adipokine, is found to be expressed in adipose tissue and correlated with obesity, insulin resistance (IR) and type 2 diabetes (T2DM). The activity of recombinant human RBP4 was measured by its ability to bind all-trans retinoic acid. The binding of retinoic acid results in the quenching of Trp fluorescence in RBP4. RBP4 was diluted to 50 ug/ml in 50 mM Tris, 10 mM CaCl2, 150 mM NaCl, pH 7.5 (assay buffer) and the retinoic acid was diluted to 100, 30, 10, 3 and 1 uM in 95% ethanol. Mixing 112.5 uL of 50 ug/mL rhRBP4 and 12.5 uL of retinoic acid serial dilutions in microtubes and a blank containing 112.5 uL of 50 ug/mL rhRBP4 and 12.5 uL of 95% ethanol, then incubate at room temperature for 30 minutes. Loading 100 ul of the reaction mixtures and blank and read at excitation and emission wavelengths of 280 nm and 340 nm (top read), respectively, in endpoint mode. The result was shown in figure 1, the 50% binding concentration (BC50) is >30 uM.)
Retinol Binding Protein 4 (RBP4), Active Protein (Cat# AAA161805)
Full Name
Active Retinol Binding Protein 4 (RBP4)
Gene Names
RBP4; RDCCAS
Applications
Activity Assay, Cell Culture
Purity
Greater than 90% by SDS-PAGE
Pricing
What Are Active Proteins?
Proteins are large molecules made up of long chains of amino acids. They will typically fold into a very particular 3-dimensional shape/conformation, that is sometimes referred to as their “native” form, which allows them to work properly in the body. For the purposes of product categorization, AAA Biotech will typically refer to proteins purified from their original animal host as being “native” proteins (this is to signify their difference compared to their recombinant proteins or “synthetic” protein counterparts).
If a protein successfully folds into the correct shape, it will typically display high fidelity characteristics to its original protein in its original animal host and be classified as an active protein, as it will be able to function “normally” in most enzymatic or binding capacities. If it loses this shape, due to factors such as heat or strong chemicals (such as detergents), it becomes inactive and is no longer able to perform its basic functions.
All of the proteins in this category are made under strict quality control, and they are active, pure, low in contaminants, and stable. Most are stored as freeze-dried powders and come without extra tags, so they’re very close to the actual natural/native form.
Learn more in our guide “How active proteins work”.
Key Applications of Active Proteins
1. Scientific Research
- Aid in the study of how proteins function in the body
- Aid in understanding various disease processes
2. Drug Development
- Powerful tools to investigate how potential drugs interact with specific proteins
- Ideal for identifying drug targets
3. Cell Culture
- Are routinely utilized to support cell growth and function (e.g., using exogenous growth factors)
- Can be used to promote cellular development into specific types (differentiation)
4. Diagnostics
- Regularly utilized in tests to detect diseases or infections (e.g., COVID-19, cancer)
- Note: All products are strictly for research-use only (RUO).
5. Therapeutics
- Some active proteins are used directly as treatments (e.g., insulin, enzymes)
- Note: All products are strictly for research-use only (RUO).
6. Vaccine Development
- Used to create or test vaccines by mimicking parts of viruses or bacteria
7. Biochemical Assays
- They can facilitate the characterization of enzyme activity, binding strength, or protein interactions in lab tests
Why Buy Active Proteins from AAA Biotech?
- High biological activity – Verified to perform as expected or indicated on datasheet
- Strict quality control – We are confident in our active proteins’ reliability and consistency
- High purity & low endotoxin – Ideal for applications involving sensitive or precious samples/components
- Freeze-dried for stability – Long shelf life and straightforward storage
- Mostly tag-free – Closer to natural/native protein form
FAQ
1. What are active proteins used for in research?
Active proteins are used primarily in the study of how proteins function, in characterizing/discovering drug interactions, supporting cell growth, running biochemical assays, and in development of diagnostics or therapeutics.
2. How are AAA Biotech's active proteins validated?
AAA Biotech’s active proteins are validated through strict quality control and functional assays to ensure they are properly folded and active. “Active”, though, can be an ambiguous term, so if a specific “activity” or “binding” capability of a protein is of crucial interest to you, please inquire with us prior to purchase, and we will provide further details on how the “Active” modifier was determined to be applicable.
3. Are these proteins tested for biological activity?
Yes, all active proteins from AAA Biotech are tested to confirm they have the expected biological activity before being offered for use. Though, said “biological activity” can be either “enzymatic”, “binding”, or both.