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AAA Biotech also known as AAA Bio or AAABio provides a variety of high-quality recombinant and natural/native proteins that are proven to work in a wide range of experiments. Explore our products to find the active protein that best fits your needs or experimental model.
Viewing 2050-2100 of 2583 product results
Bioactivity
(Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) is an protein belongs to the tissue inhibitor of metalloproteinases family. They are inhibitors of the matrix metalloproteinases. TIMP-3 is the only member of the TIMP family which is found exclusively in the extracellular matrix (ECM). It is regulated in a cell cycle-dependent fashion in certain cell types and may serve as a marker for terminal differentiation. The activity of recombinant bovine TIMP3 was measured by its ability to inhibit rhMMP2 cleavage of a fluorogenic peptide substrate MCA-Pro-Leu-Gly-Leu-DPA-Ala-Arg-NH2 in the assay buffer 50 mM Tris, 10 mM CaCl2, 150 mM NaCl, 0.05% (w/v) Brij-35, pH 7.5. rhMMP2 was diluted to 100 ug/ml and activated with 1 mM APMA at 37 degree C for 1 hour and rbTIMP3 (MW: 23.25 KD) was diluted to different concentrations with the assay buffer. Mix 8 ul of rbTIMP3 curve dilutions, 12.8 ul of activated rhMMP-2, and 59.2 ul of assay buffer, including a control containing assay buffer and the diluted rhMMP-2 and incubate the reactions for 2 hours at 37 degree C. Loading 50 ul of the incubated mixtures which were diluted five-fold in assay buffer into empty wells of a plate, and start the reaction by adding 50 ul of 20 uM substrate. Include a substrate blank containing 50 ul of assay buffer and 50 ul of 20 uM substrate. Then read at excitiation and emission wavelengths of 320 nm and 405 nm, respectively, in kinetic mode for 5 minutes. The result was shown in Figure 1 and it was obvious that recombinant bovine TIMP3 significantly decreased rhMMP2 activity. The inhibition IC50 was )
Tissue Inhibitors Of Metalloproteinase 3 (TIMP3), Active Protein (Cat# AAA161700)
Full Name
Active Tissue Inhibitors Of Metalloproteinase 3 (TIMP3)
Gene Names
TIMP3; TIMP-3
Applications
Activity Assay, Cell Culture
Purity
Greater than 95% by SDS-PAGE
Pricing
Bioactivity
(Complement Component 3a (C3a) is a component of the complement system, this protein is also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. It's been identified that C3A can interact with Complement Factor I (CFI), thus a functional binding ELISA assay was conducted to detect the interaction of recombinant human C3a and recombinant human CFI. Briefly, C3a was diluted serially in PBS with 0.01% BSA (pH 7.4). Duplicate samples of 100 ul were then transferred to CFI-coated microtiter wells and incubated for 1h at 37 degree C. Wells were washed with PBST and incubated for 1h with anti-C3a pAb, then aspirated and washed 3 times. After incubation with HRP labelled secondary antibody for 1h at 37 degree C, wells were aspirated and washed 5 times. With the addition of substrate solution, wells were incubated 15-25 minutes at 37 degree C. Finally, add 50 uL stop solution to the wells and read at 450/630 nm immediately. The binding activity of recombinant human C3a and recombinant human CFI was shown in Figure 1, the EC50 for this effect is 0.03 ug/mL.)
Complement Component 3a (C3a), Active Protein (Cat# AAA161726)
Full Name
Active Complement Component 3a (C3a)
Gene Names
C3; ASP; C3a; C3b; AHUS5; ARMD9; CPAMD1
Applications
Activity Assay, Cell Culture
Purity
Greater than 95% by SDS-PAGE
Pricing
Bioactivity
(Galectin 3 (GAL3) is a member of the lectin family, of which 14 mammalian galectins have been identified. It is also a member of the beta-galactoside-binding protein family that plays an important role in cell-cell adhesion, cell-matrix interactions, macrophage activation, angiogenesis, metastasis, apoptosis. The protein also has been demonstrated to be involved in cancer, inflammation and fibrosis, heart disease, and stroke. GAL3 is expressed in the nucleus, cytoplasm, mitochondrion, cell surface, and extracellular space. It also can agglutinate red blood. In this case, we chose rabbit erythrocyte (RaE) to assay its ability of agglutination. A general procedure for hemagglutination assay (or haemagglutination assay; HA) is as follows, two-fold dilute the recombinant mouse GAL3 with 0.9% sodium chloride injection, add 50uL a serial dilution of GAL3 to each well of a U or V-bottom shaped 96-well microtiter plate. The final well serves as a negative control without GAL3, replace with 50uL 0.9% sodium chloride injection. Then add 50uL 1% rabbit erythrocyte to each well and mixed gently. The plate is incubated for 3 hours at room temperature. The results are shown in Figure 1. It was obvious that the minimal effective concentration of GAL3 is 3.1ug/ml.)
Galectin 3 (GAL3), Active Protein (Cat# AAA152172)
Full Name
Active Galectin 3 (GAL3)
Gene Names
Lgals3; GBP; L-34; gal3; Mac-2
Applications
Activity Assay, Cell Culture
Purity
Greater than 97% by SDS-PAGE
Pricing
Bioactivity
(Fibroblast Growth Factor 9 (FGF9) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, ce)
Fibroblast Growth Factor 9 (FGF9), Active Protein (Cat# AAA152957)
Full Name
Active Fibroblast Growth Factor 9 (FGF9)
Gene Names
Fgf9; Eks
Applications
Activity Assay, Cell Culture
Purity
Greater than 95% by SDS-PAGE
Pricing
Bioactivity
(Figure 2. The dose-effect curve of IL-3 on TF-1 cells)
Interleukin 3 (IL3), Active Protein (Cat# AAA152968)
Full Name
Active Interleukin 3 (IL3)
Gene Names
IL3; IL-3; MCGF; MULTI-CSF
Applications
Activity Assay, Cell Culture
Purity
Greater than 90% by SDS-PAGE
Pricing
Bioactivity
(Figure 2. Inhibition of HepG2 cells proliferation after stimulated with TGF-beta1.)
Transforming Growth Factor Beta 1 (TGFb1), Active Protein (Cat# AAA152982)
Full Name
Active Transforming Growth Factor Beta 1 (TGFb1)
Applications
Activity Assay, Cell Culture
Purity
Greater than 97% by SDS-PAGE
Pricing
Bioactivity
(Figure 2. Inhibition of A549 cells proliferation after stimulated with TNFalpha.)
Tumor Necrosis Factor Alpha (TNFa), Active Protein (Cat# AAA152991)
Full Name
Active Tumor Necrosis Factor Alpha (TNFa)
Gene Names
TNF; TNFa
Applications
Activity Assay, Cell Culture
Purity
Greater than 90% by SDS-PAGE
Pricing
Bioactivity
(Neutrophil elastase (NE), also known as polymorphonuclear leukocyte elastase, is a major protease in the primary granules of neutrophils, is involved in microbicidal activity. It is located primarily in the azurophil granules of polymorphonuclear leukocyt)
Neutrophil Elastase (NE), Active Protein (Cat# AAA153000)
Full Name
Active Neutrophil Elastase (NE)
Gene Names
Elane; NE; Ela2; F430011M15Rik
Applications
Activity Assay, Cell Culture
Purity
Greater than 97% by SDS-PAGE
Pricing
Bioactivity
(The interleukin-1 receptor antagonist (IL-1RA) is a member of the interleukin 1 cytokine family. IL1Ra is secreted by various types of cells including immune cells, epithelial cells, and adipocytes, and is a natural inhibitor of the pro-inflammatory effec)
Interleukin 1 Receptor Antagonist (IL1RA), Active Protein (Cat# AAA153008)
Full Name
Active Interleukin 1 Receptor Antagonist (IL1RA)
Gene Names
IL1RN; IRAP; IL-1RN; IL-1ra
Applications
Activity Assay, Cell Culture
Purity
Greater than 90% by SDS-PAGE
Pricing
Bioactivity
(Figure 2. The hemagglutination assay of GAL12 in V- bottom shaped 96-well microtiter plate.)
Galectin 12 (GAL12), Active Protein (Cat# AAA153027)
Full Name
Active Galectin 12 (GAL12)
Applications
Activity Assay, Cell Culture
Purity
Greater than 90% by SDS-PAGE
Pricing
Bioactivity
(Lactotransferrin (LTF), also known as actoferrin (LF) , is a multifunctional protein of the transferrin family. Lactoferrin belongs to the innate immune system. Apart from its main biological function, namely binding and transport of iron ions, lactoferri)
Lactoferrin (LTF), Active Protein (Cat# AAA153058)
Full Name
Active Lactoferrin (LTF)
Gene Names
LTF; PLF
Applications
Activity Assay, Cell Culture
Purity
Greater than 90% by SDS-PAGE
Pricing
Bioactivity
(Programmed Cell Death 1 Ligand 2 (also known as PD-L2, B7-DC) is a member of the B7 family of proteins that provide signals for regulating T-cell activation and tolerance. Mature human PD-L2 consists of a 201 amino acid (aa) extracellular domain (ECD) wit)
Programmed Cell Death Protein 1 Ligand 2 (PDL2), Active Protein (Cat# AAA153059)
Full Name
Active Programmed Cell Death Protein 1 Ligand 2 (PDL2)
Gene Names
PDCD1LG2; B7DC; Btdc; PDL2; CD273; PD-L2; PDCD1L2; bA574F11.2
Applications
Activity Assay, Cell Culture
Purity
Greater than 95% by SDS-PAGE
Pricing
Bioactivity
(Extracellular matrix metalloproteinase (MMP) inducer (EMMPRIN), also known as basigin and CD147, is a 4466 kDa, variably N and Oglycosylated, type I transmembrane protein that belongs to the immunoglobulin superfamily. Human EMMPRIN is 269 amino acids (aa)
Cluster Of Differentiation 147 (CD147), Active Protein (Cat# AAA153101)
Full Name
Active Cluster Of Differentiation 147 (CD147)
Gene Names
Bsg; CE9; HT7; 5A11; Ox47R; EMMPRIN; basignin
Applications
Activity Assay, Cell Culture
Purity
Greater than 95% by SDS-PAGE
Pricing
SDS_PAGE
(Sample: Active recombinant SOD1, Human)
Superoxide Dismutase 1 (SOD1), Active Protein (Cat# AAA153106)
Full Name
Active Superoxide Dismutase 1 (SOD1)
Gene Names
SOD1; ALS; SOD; ALS1; IPOA; hSod1; HEL-S-44; homodimer
Reactivity
Homo sapiens (Human)
Applications
Activity Assay, Cell Culture
Purity
>90%
Pricing
Bioactivity
(17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3) belongs to the HSD17B family with NAD(P)H/NAD(P) -dependent oxidoreductase activity that catalyzes the interconversion between 17-ketosteroids and 17-hydroxysteroids to maintain the balance between les)
17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3), Active Protein (Cat# AAA153131)
Full Name
Active 17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3)
Gene Names
HSD17B3; EDH17B3; SDR12C2
Applications
Activity Assay, Cell Culture
Purity
Greater than 90% by SDS-PAGE
Pricing
Application Data
FGF10, Active Protein (Cat# AAA214219)
Full Name
Recombinant Human FGF10
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
G-CSF (CSF3), Active Protein (Cat# AAA214220)
Full Name
Recombinant Human G-CSF (CSF3)
Gene Names
CSF3; GCSF; CSF3OS; C17orf33
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
GM-CSF (CSF2), Active Protein (Cat# AAA214222)
Full Name
Recombinant Human GM-CSF (CSF2)
Gene Names
CSF2; CSF; GMCSF
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
PDGFA, Active Protein (Cat# AAA214228)
Full Name
Recombinant Human PDGFA
Gene Names
PDGFA; PDGF1; PDGF-A
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
IL11, Active Protein (Cat# AAA214230)
Full Name
Recombinant Human IL11
Gene Names
IL11; AGIF; IL-11
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
IL13, Active Protein (Cat# AAA214231)
Full Name
Recombinant Human IL13
Gene Names
IL13; P600; IL-13
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
IL17A, Active Protein (Cat# AAA214233)
Full Name
Recombinant Human IL17A
Gene Names
IL17A; IL17; CTLA8; IL-17; CTLA-8; IL-17A
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
KGF (FGF7), Active Protein (Cat# AAA214239)
Full Name
Recombinant Human KGF (FGF7)
Gene Names
FGF7; KGF; HBGF-7
Purity
>95% as determined by SDS-PAGE
Pricing
Lymphotactin (XCL1), Active Protein (Cat# AAA214241)
Full Name
Recombinant Human Lymphotactin (XCL1)
Gene Names
XCL1; LTN; ATAC; LPTN; SCM1; SCM-1; SCM1A; SCYC1; SCM-1a
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
MCP-4 (CCL13), Active Protein (Cat# AAA214244)
Full Name
Recombinant Human MCP-4 (CCL13)
Gene Names
CCL13; NCC1; CKb10; MCP-4; NCC-1; SCYL1; SCYA13
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
M-CSF (CSF1), Active Protein (Cat# AAA214245)
Full Name
Recombinant Human M-CSF (CSF1)
Gene Names
CSF1; MCSF; CSF-1
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
OSM, Active Protein (Cat# AAA214249)
Full Name
Recombinant Human OSM
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
PTH, Active Protein (Cat# AAA214250)
Full Name
Recombinant Human PTH
Gene Names
PTH; PTH1
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
LTA, Active Protein (Cat# AAA214254)
Full Name
Recombinant Human LTA
Gene Names
LTA; LT; TNFB; TNFSF1; TNLG1E
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
MIF, Active Protein (Cat# AAA214256)
Full Name
Recombinant Human MIF
Gene Names
MIF; GIF; GLIF; MMIF
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
CCL22, Active Protein (Cat# AAA214259)
Full Name
Recombinant Human CCL22
Gene Names
CCL22; MDC; ABCD-1; SCYA22; STCP-1; DC/B-CK; A-152E5.1
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
TSLP, Active Protein (Cat# AAA214262)
Full Name
Recombinant Human TSLP
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
EPO, Active Protein (Cat# AAA214265)
Full Name
Recombinant Human EPO
Gene Names
EPO; EP; DBAL; ECYT5; MVCD2
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
FGF2, Active Protein (Cat# AAA214267)
Full Name
Recombinant Human FGF2
Gene Names
FGF2; BFGF; FGFB; FGF-2; HBGF-2
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
IFNA2, Active Protein (Cat# AAA214269)
Full Name
Recombinant Human IFNA2
Gene Names
IFNA2; IFNA; INFA2; IFNA2B; IFN-alphaA
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
IL8, Active Protein (Cat# AAA214270)
Full Name
Recombinant Human IL8 (72aa)
Gene Names
CXCL8; IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
FGF20, Active Protein (Cat# AAA214273)
Full Name
Recombinant Human FGF20
Gene Names
FGF20; RHDA2; FGF-20
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
Leptin (LEP), Active Protein (Cat# AAA214276)
Full Name
Recombinant Human Leptin (LEP)
Gene Names
LEP; OB; OBS; LEPD
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
MANF, Active Protein (Cat# AAA214286)
Full Name
Recombinant Human MANF
Gene Names
MANF; ARP; ARMET
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
VEGF, Active Protein (Cat# AAA214288)
Full Name
Recombinant Human VEGF (121aa)
Gene Names
Alpi; Alp1; S51097
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
IGF2, Active Protein (Cat# AAA214298)
Full Name
Recombinant Human IGF2
Gene Names
IGF2; GRDF; IGF-II; PP9974; C11orf43
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
Maspin (SerpinB5), Active Protein (Cat# AAA214304)
Full Name
Recombinant Human Maspin (SerpinB5)
Gene Names
SERPINB5; PI5; maspin
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
TWEAK Receptor (TNFRSF12A), Active Protein (Cat# AAA214305)
Full Name
Recombinant Human TWEAK Receptor (TNFRSF12A)
Gene Names
TNFRSF12A; FN14; CD266; TWEAKR
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
IL1A, Active Protein (Cat# AAA214312)
Full Name
Recombinant Mouse IL1A
Gene Names
Il1a; Il-1a
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
IL1B, Active Protein (Cat# AAA214313)
Full Name
Recombinant Mouse IL1B
Gene Names
Il1b; Il-1b; IL-1beta
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
Beta-Defensin 1 (DEFB1), Active Protein (Cat# AAA214324)
Full Name
Recombinant Mouse Beta-Defensin 1 (DEFB1)
Gene Names
Defb1; BD-1; AW260221
Reactivity
Mouse (M. musculus)
Purity
>95% as determined by SDS-PAGE
Pricing
Application Data
CXCL2, Active Protein (Cat# AAA214341)
Full Name
Recombinant Rat CXCL2
Gene Names
Cxcl2; Mip-2; Scyb2
Purity
>95% as determined by SDS-PAGE
Pricing
p38 alpha, Active Protein (Cat# AAA214350)
Full Name
Recombinant Human p38 alpha (N-GST tag)
Gene Names
MAPK14; RK; p38; CSBP; EXIP; Mxi2; CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; SAPK2A; p38ALPHA
Purity
70%-90%
Pricing
PHKG2, Active Protein (Cat# AAA214352)
Full Name
Recombinant Human PHKG2 (N-GST tag)
Gene Names
PHKG2; GSD9C
Pricing
What Are Active Proteins?
Proteins are large molecules made up of long chains of amino acids.
They will typically fold into a very particular 3-dimensional shape/conformation, that is sometimes referred to as their “native” form, which allows them to work properly in the body. For the purposes of product categorization, AAA Biotech will typically refer to proteins purified from their original animal host as being “native” proteins (this is to signify their difference compared to their “recombinant” or “synthetic” protein counterparts).
If a protein successfully folds into the correct shape, it is will typically display high fidelity characteristics to its original protein in its original animal host, and be classified as an active protein, as it will be able to function “normally” in most enzymatic or binding capacities. If it loses this shape, due to factors such as heat or strong chemicals (such as detergents), it becomes inactive and is no longer able to perform its basic functions. All of the proteins in this category are made under strict quality control, and they are active, pure, low in contaminants, and stable.
Most are stored as freeze-dried powders and come without extra tags, so they’re very close to the actual natural/native form.
Key Applications of Active Proteins
1. Scientific Research
- Aid in the study of how proteins function in the body
- Aid in understanding various disease processes
2. Drug Development
- Powerful tools to investigate how potential drugs interact with specific proteins
- Ideal for identifying drug targets
3. Cell Culture
- Are routinely utilized to support cell growth and function (e.g., using exogenous growth factors)
- Can be used to promote cellular development into specific types (differentiation)
4. Diagnostics
- Regularly utilized in tests to detect diseases or infections (e.g., COVID-19, cancer)
- Note: All products are strictly for research-use only (RUO).
5. Therapeutics
- Some active proteins are used directly as treatments (e.g., insulin, enzymes)
- Note: All products are strictly for research-use only (RUO).
6. Vaccine Development
- Used to create or test vaccines by mimicking parts of viruses or bacteria
7. Biochemical Assays
- They can facilitate the characterization of enzyme activity, binding strength, or protein interactions in lab tests
Why Buy Active Proteins from AAA Biotech?
- High biological activity – Verified to perform as expected or indicated on datasheet
- Strict quality control – We are confident in our active proteins’ reliability and consistency
- High purity & low endotoxin – Ideal for applications involving sensitive or precious samples/components
- Freeze-dried for stability – Long shelf life and straightforward storage
- Mostly tag-free – Closer to natural/native protein form
FAQ
1. What are active proteins used for in research?
Active proteins are used primarily in the study of how proteins function, in characterizing/discovering drug interactions, supporting cell growth, running biochemical assays, and in development of diagnostics or therapeutics.
2. How are AAA Biotech's active proteins validated?
AAA Biotech’s active proteins are validated through strict quality control and functional assays to ensure they are properly folded and active. “Active”, though, can be an ambiguous term, so if a specific “activity” or “binding” capability of a protein is of crucial interest to you, please inquire with us prior to purchase, and we will provide further details on how the “Active” modifier was determined to be applicable.
3. Are these proteins tested for biological activity?
Yes, all active proteins from AAA Biotech are tested to confirm they have the expected biological activity before being offered for use. Though, said “biological activity” can be either “enzymatic”, “binding”, or both.